Cryogenic modulation fast GC × GC-MS using a 10 m microbore column combination: Concept, method optimization, and application

2018 ◽  
Vol 41 (5) ◽  
pp. 1112-1117 ◽  
Author(s):  
Barbara Giocastro ◽  
Marco Piparo ◽  
Peter Q. Tranchida ◽  
Luigi Mondello
Keyword(s):  
Fast Gc ◽  
Method Optimization ◽  
Cryogenic Modulation ◽  
Microbore Column

scholarly journals Box-Behnken Assisted Validation and Optimization of an RP-HPLC Method for Simultaneous Determination of Domperidone and Lansoprazole

Separations ◽  
2021 ◽  
Vol 8 (1) ◽  
pp. 5
Author(s):  
Mohd Afzal ◽  
Mohd. Muddassir ◽  
Abdullah Alarifi ◽  
Mohammed Tahir Ansari
Keyword(s):  
Flow Rate ◽  
Mobile Phase ◽  
Limit Of Detection ◽  
Hplc Method ◽  
Box Behnken Design ◽  
Rp Hplc ◽  
System Suitability ◽  
Method Optimization ◽  
Key Variables

A highly specific, accurate, and simple RP-HPLC technique was developed for the real-time quantification of domperidone (DOMP) and lansoprazole (LANS) in commercial formulations. Chromatographic studies were performed using a Luna C8(2), 5 μm, 100Å, column (250 × 4.6 mm, Phenomenex) with a mobile phase composed of acetonitrile/2 mM ammonium acetate (51:49 v/v), pH 6.7. The flow rate was 1 mL·min−1 with UV detection at 289 nm. Linearity was observed within the range of 4–36 µg·mL−1 for domperidone and 2–18 µg·mL−1 for lansoprazole. Method optimization was achieved using Box-Behnken design software, in which three key variables were examined, namely, the flow rate (A), the composition of the mobile phase (B), and the pH (C). The retention time (Y1 and Y3) and the peak area (Y2 and Y4) were taken as the response parameters. We observed that slight alterations in the mobile phase and the flow rate influenced the outcome, whereas the pH exerted no effect. Method validation featured various ICH parameters including linearity, limit of detection (LOD), accuracy, precision, ruggedness, robustness, stability, and system suitability. This method is potentially useful for the analysis of commercial formulations and laboratory preparations.

scholarly journals Bas‐relief layout arrangement via automatic method optimization

2021 ◽  
Author(s):  
Jiahui Mao ◽  
Tingting Li ◽  
Feiyu Zhang ◽  
Meili Wang ◽  
Jian Chang ◽  
...  
Keyword(s):  
Automatic Method ◽  
Method Optimization

Strategizing method optimization of microwave-assisted extraction of plant phenolics by developing standard working principles for universal robust optimization

2017 ◽  
Vol 9 (13) ◽  
pp. 2089-2103 ◽  
Author(s):  
Harneet Kaur Kala ◽  
Rajendra Mehta ◽  
Kamal Kumar Sen ◽  
Roshni Tandey ◽  
Vivekananda Mandal
Keyword(s):  
Global Optimization ◽  
Robust Optimization ◽  
Green Technology ◽  
Microwave Assisted Extraction ◽  
Plant Phenolics ◽  
Food Industries ◽  
Microwave Assisted ◽  
Assisted Extraction ◽  
Method Optimization

Empowering botanical extraction through microwave based green technology by proposing 8 golden principles for global optimization. A much needed boost for research in the pharma and food industries.

Response Surface Method Optimization of Uniform and Axially Segmented Duct Acoustics Liners

2006 ◽  
Vol 43 (4) ◽  
pp. 1089-1102 ◽  
Author(s):  
L. Lafronza ◽  
A. McAlpine ◽  
A. J. Keane ◽  
R. J. Astley
Keyword(s):  
Response Surface ◽  
Response Surface Method ◽  
Duct Acoustics ◽  
Surface Method ◽  
Method Optimization
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