Efficient separation of curcumin, demethoxycurcumin, and bisdemethoxycurcumin from turmeric using supercritical fluid chromatography: From analytical to preparative scale

2015 ◽  
Vol 38 (19) ◽  
pp. 3450-3453 ◽  
Author(s):  
Wei Song ◽  
Xue Qiao ◽  
Wen-fei Liang ◽  
Shuai Ji ◽  
Lu Yang ◽  
...  
Keyword(s):  
Supercritical Fluid ◽  
Supercritical Fluid Chromatography ◽  
Preparative Scale ◽  
Efficient Separation

scholarly journals Customization of a Commercially Available Prep Scale SFC System to Provide Enhanced Capabilities

2002 ◽  
Vol 7 (4) ◽  
pp. 69-74 ◽  
Author(s):  
Jeff Olson ◽  
Jeff Pan ◽  
Jill Hochlowski ◽  
Philip Searle ◽  
Dave Blanchard
Keyword(s):  
Drug Discovery ◽  
Environmental Impact ◽  
Supercritical Fluid ◽  
Supercritical Fluid Chromatography ◽  
Lower Cost ◽  
Discovery Process ◽  
Drug Discovery Process ◽  
High Recovery ◽  
Preparative Scale ◽  
Complex Chemical

Preparative Scale Supercritical Fluid Chromatography is emerging as a powerful alternative to HPLC for the purification and separation of complex chemical reaction mixtures. Advantages include greatly reduced solvent usage (and thus lower cost and environmental impact), higher throughput, and in some cases higher resolution. While there are commercially available prep SFC instruments, none currently offer all the features desired by many medicinal chemists engaged in the drug discovery process. These include: the ability to collect an unlimited number of fractions per sample with high recovery and negligible carryover, fully automated capacity to collect several hundred fractions, and the ability to collect fractions into the same disposable test tubes and racks which are already employed in HPLC. This article describes the customization of a preparatory scale SFC system purchased from Berger Instruments, Inc., Newark, DE. (a subsidiary Mettler-Toledo International, Inc., of Greifensee, Switzerland) in order to provide these capabilities.

Preparative-scale supercritical fluid chromatography

1995 ◽  
Vol 697 (1-2) ◽  
pp. 579-585 ◽  
Author(s):  
Keith D. Bartle ◽  
Christopher D. Bevan ◽  
Anthony A. Clifford ◽  
Saad A. Jafar ◽  
Naila Malak ◽  
...  
Keyword(s):  
Supercritical Fluid ◽  
Supercritical Fluid Chromatography ◽  
Preparative Scale

Generic Enhanced Sub/Supercritical Fluid Chromatography: Blueprint for Highly Productive and Sustainable Separation of Primary Hindered Amines

2020 ◽  
Vol 8 (15) ◽  
pp. 6011-6021 ◽  
Author(s):  
Jimmy Oliveira DaSilva ◽  
Dan Lehnherr ◽  
Jinchu Liu ◽  
Raffeal Bennett ◽  
Imad A. Haidar Ahmad ◽  
...  
Keyword(s):  
Supercritical Fluid ◽  
Supercritical Fluid Chromatography ◽  
Hindered Amines
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