Analysis of selected ionic liquid cations by ion exchange chromatography and reversed-phase high performance liquid chromatography

2005 ◽  
Vol 28 (2) ◽  
pp. 149-154 ◽  
Author(s):  
Piotr Stepnowski ◽  
Wojciech Mrozik
Keyword(s):  
Ionic Liquid ◽  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Ion Exchange ◽  
High Performance ◽  
Reversed Phase ◽  
Ion Exchange Chromatography ◽  
Exchange Chromatography

Quantitation of o- and p-Sulfamoylbenzoic Acids in Commercial Saccharin by High-Performance Liquid Chromatography

1976 ◽  
Vol 59 (2) ◽  
pp. 243-250
Author(s):  
James J Nelson
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Ion Exchange ◽  
Sodium Salt ◽  
Mobile Phase ◽  
High Performance ◽  
Ion Exchange Chromatography ◽  
Exchange Chromatography ◽  
Anion Exchange Column ◽  
Para Isomer

Abstract Quantitation of o- and p-sulfamoylbenzoic acid residues in saccharin and its sodium salt is achieved by a method comprising methanolic extraction and high-performance ion exchange chromatography. A commercially available anion exchange column was employed with an aqueous buffered (pH 9.2) mobile phase. As little as 80 ppm of the ortho-isomer and 25 ppm of the para-isomer can be accurately determined. The levels of detectability (2 times noise) are estimated as 8 ppm (0.16 μg on column) and 2.5 ppm (0.05 μg on column), respectively. Recoveries from saccharin ranged from 92.7 to 96.5% (ortho) and from 92.2 to 103.3% (para). Recoveries from the sodium salt ranged from 93.1 to 104.4% (ortho) and from 93.5 to 97.8% (para). Of 9 other potential saccharin impurities tested separately, only one was found to interfere slightly in the chromatographic part of the procedure.

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