scholarly journals Therapeutic potential of growth differentiation factors in the treatment of degenerative disc diseases

JOR Spine ◽  
2019 ◽  
Vol 2 (1) ◽  
pp. e1045 ◽  
Author(s):  
Tom Hodgkinson ◽  
Bojiang Shen ◽  
Ashish Diwan ◽  
Judith A. Hoyland ◽  
Stephen M. Richardson
Keyword(s):  
Therapeutic Potential ◽  
Degenerative Disc ◽  
Differentiation Factors ◽  
Growth Differentiation Factors

Mesenchymal Stem Cells Differentiation: Mitochondria Matter in Osteogenesis or Adipogenesis Direction

2020 ◽  
Vol 15 (7) ◽  
pp. 602-606
Author(s):  
Kun Ji ◽  
Ling Ding ◽  
Xi Chen ◽  
Yun Dai ◽  
Fangfang Sun ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Therapeutic Potential ◽  
Mesodermal Cell ◽  
Cell Lineages ◽  
Current Review ◽  
Differentiation Factors ◽  
The Relationship ◽  
Msc Differentiation

Mesenchymal Stem Cells (MSCs) exhibit enormous therapeutic potential because of their indispensable regenerative, reparative, angiogenic, anti-apoptotic, and immunosuppressive properties. MSCs can best differentiate into mesodermal cell lineages, including osteoblasts, adipocytes, muscle cells, endothelial cells and chondrocytes. Specific differentiation of MSCs could be induced through limited conditions. In addition to the relevant differentiation factors, drastic changes also occur in the microenvironment to conduct it in an optimal manner for particular differentiation. Recent evidence suggests that the mitochondria participate in the regulating of direction and process of MSCs differentiation. Therefore, our current review focuses on how mitochondria participate in both osteogenesis and adipogenesis of MSC differentiation. Besides that, in our current review, we try to provide a further understanding of the relationship between the behavior of mitochondria and the direction of MSC differentiation, which could optimize current cellular culturing protocols for further facilitating tissue engineering by adjusting specific conditions of stem cells.

Dual release of a hydrophilic and a hydrophobic osteogenic factor from a single liposome

RSC Advances ◽  
2016 ◽  
Vol 6 (115) ◽  
pp. 114599-114612 ◽  
Author(s):  
Nelson Monteiro ◽  
Albino Martins ◽  
Ricardo A. Pires ◽  
Susana Faria ◽  
Nuno A. Fonseca ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Osteogenic Differentiation ◽  
Differentiation Factors ◽  
Dual Release ◽  
Osteogenic Factor ◽  
Growth Differentiation Factors

Dual release of growth/differentiation factors from liposomes induced osteogenic differentiation of mesenchymal stem cells.

scholarly journals Leukocyte Production of Inflammatory Mediators Is Inhibited by the Antioxidants Phloretin, Silymarin, Hesperetin, and Resveratrol

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Jezrom B. Fordham ◽  
Afsar Raza Naqvi ◽  
Salvador Nares
Keyword(s):  
Inflammatory Mediators ◽  
Mononuclear Cells ◽  
Therapeutic Potential ◽  
Aggregatibacter Actinomycetemcomitans ◽  
Significant Inhibition ◽  
Periodontal Pathogen ◽  
Enzyme Linked Immunosorbent Assay ◽  
Peripheral Blood Mononuclear ◽  
Differentiation Factors

Antioxidants possess significant therapeutic potential for the treatment of inflammatory disorders. One such disorder is periodontitis characterised by an antimicrobial immune response, inflammation, and irreversible changes to the supporting structures of the teeth. Recognition of conserved pathogen-associated molecular patterns is a crucial component of innate immunity to Gram-negative bacteria such asEscherichia coli, as well as the periodontal pathogenAggregatibacter actinomycetemcomitans. In this study, we investigated the antioxidants Phloretin, Silymarin, Hesperetin, and Resveratrol to ascertain whether they altered the production of inflammatory mediators by innately-activated leukocytes. Peripheral blood mononuclear cells were stimulated with lipopolysaccharide purified fromAggregatibacter actinomycetemcomitans, and the production of cytokines, chemokines, and differentiation factors was assayed by enzyme-linked immunosorbent assay, cytometric bead array, and RT-PCR. Significant inhibition of these factors was achieved upon treatment with Phloretin, Silymarin, Hesperetin, and Resveratrol. These data further characterise the potent anti-inflammatory properties of antioxidants. Their ability to inhibit the production of inflammatory cytokines, chemokines, and differentiation factors by a heterogeneous population of leukocytes has clear implications for their therapeutic potentialin vivo.

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