Role of tumor-infiltrating lymphocytes in the host defense mechanism against lung cancer

1988 ◽  
Vol 38 (4) ◽  
pp. 221-226 ◽  
Author(s):  
Kosei Yasumoto ◽  
Sadanori Takeo ◽  
Tokujiro Yano ◽  
Hisashi Nakahashi ◽  
Akira Nagashima ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Host Defense ◽  
Defense Mechanism ◽  
Tumor Infiltrating Lymphocytes ◽  
Host Defense Mechanism ◽  
Infiltrating Lymphocytes

scholarly journals The Role of Tumor-Infiltrating Lymphocytes in Development, Progression, and Prognosis of Non–Small Cell Lung Cancer

2016 ◽  
Vol 11 (6) ◽  
pp. 789-800 ◽  
Author(s):  
Roy M. Bremnes ◽  
Lill-Tove Busund ◽  
Thomas L. Kilvær ◽  
Sigve Andersen ◽  
Elin Richardsen ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Tumor Infiltrating Lymphocytes ◽  
Small Cell ◽  
Small Cell Lung ◽  
Infiltrating Lymphocytes

scholarly journals The Prognostic Value of Sex-Determining Region Y-Box 2 and CD8+ Tumor-Infiltrating Lymphocytes in Limited-Stage Small-Cell Lung Cancer

Oncology ◽  
2021 ◽  
pp. 1-11
Author(s):  
Jinsoo Lee ◽  
Yoon Yang Jung ◽  
Jung Hoon Lee ◽  
Mineui Hong ◽  
Hye-Won Hwang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Prognostic Value ◽  
Tumor Infiltrating Lymphocytes ◽  
Small Cell ◽  
Small Cell Lung ◽  
Prognostic Role ◽  
Sox2 Expression ◽  
Infiltrating Lymphocytes

<b><i>Background:</i></b> Sex-determining region Y-box 2 (SOX2) is a transcriptional factor that drives embryonic stem cells to neuroendocrine cells in lung development and is highly expressed in small-cell lung cancer (SCLC). However, the prognostic role of SOX2 and its relationship with tumor-infiltrating lymphocytes (TILs) has not been determined in SCLC. Herein, we assessed the expression of SOX2 and CD8+ TILs to obtain insights into the prognostic role of SOX2 and CD8+ TILs in limited-stage (LS)-SCLC. <b><i>Methods:</i></b> A total of 75 patients with LS-SCLC was enrolled. The SOX2 expression and CD8+ TILs were evaluated by immunohistochemistry. <b><i>Results:</i></b> High SOX2 and CD8+ TIL levels were identified in 52 (69.3%) and 40 (53.3%) patients, respectively. High SOX2 expression was correlated with increased density of CD8+ TILs (<i>p</i> = 0.041). Unlike SOX2, high CD8+ TIL numbers were associated with significantly longer progression-free survival (PFS; 13.9 vs. 8.0 months, <i>p</i> = 0.014). Patients with both high SOX2 expression and CD8+ TIL numbers (<i>n</i> = 29, 38.7%) had significantly longer PFS and overall survival (OS) compared to those from the other groups (median PFS 19.3 vs. 8.4 months; <i>p</i> = 0.002 and median OS 35.7 vs. 17.4 months; <i>p</i> = 0.004, respectively). Multivariate Cox regression analysis showed that the combination of high SOX2 expression and CD8+ TIL levels was an independent good prognostic factor for OS (HR = 0.471, 95% CI, 0.250–0.887, <i>p</i> = 0.02) and PFS (HR = 0.447, 95% CI, 0.250–0.801, <i>p</i> = 0.007) in SCLC. <b><i>Conclusions:</i></b> Evaluation of the combination of SOX2 and CD8+ TIL levels may be of a prognostic value in LS-SCLC.

Phagocytosis and the microtubule cytoskeleton

2002 ◽  
Vol 80 (5) ◽  
pp. 509-515 ◽  
Author(s):  
Rene E Harrison ◽  
Sergio Grinstein
Keyword(s):  
Host Defense ◽  
Defense Mechanism ◽  
Fc Receptor ◽  
Signaling Proteins ◽  
Microtubule Cytoskeleton ◽  
Complex Sequence ◽  
Sequence Of Events ◽  
Host Defense Mechanism

Phagocytosis is a critical host defense mechanism used by macrophages and neutrophils to clear invading pathogens. The complex sequence of events resulting in internalization and degradation of the pathogens is a coordinated process involving lipids, signaling proteins, and the cytoskeleton. Here, we examine the role of the microtubule cytoskeleton in supporting both the engulfment of pathogens and their elimination within phagolysosomes.Key words: macrophage, microtubule, phagocytosis, maturation, Fc receptor.

Possible role of macrophages induced by an irridoid glycoside (RLJ-NE-299A) in host defense mechanism

2011 ◽  
Vol 11 (1) ◽  
pp. 128-135 ◽  
Author(s):  
Tabasum Sidiq ◽  
Anamika Khajuria ◽  
Pankaj Suden ◽  
Rohit Sharma ◽  
Surjeet Singh ◽  
...  
Keyword(s):  
Host Defense ◽  
Defense Mechanism ◽  
Host Defense Mechanism

scholarly journals Prognostic Role of Tumor-Infiltrating Lymphocytes in Lung Cancer: a Meta-Analysis

2015 ◽  
Vol 37 (4) ◽  
pp. 1560-1571 ◽  
Author(s):  
Yiting Geng ◽  
Yingjie Shao ◽  
Wenting He ◽  
Wenwei Hu ◽  
Yanjie Xu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
T Cells ◽  
Cancer Patients ◽  
Meta Analysis ◽  
Tumor Infiltrating Lymphocytes ◽  
Prognostic Role ◽  
Lung Cancer Patients ◽  
High Level ◽  
Infiltrating Lymphocytes

Background/Aims: The role of Tumor-infiltrating lymphocytes (TILs) in the prognosis of patients with lung cancer is still controversial. We performed a meta-analysis to evaluate the prognostic role of TILs in lung cancer. Methods: Studies were recruited by searching PubMed, Embase and the Cochrane Library and assessed by further quality evaluation. The pooled hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated to investigate the association between TIL subsets and lung cancer patients' outcome. Results: A total of 29 articles including 8,600 patients were enrolled into the meta-analysis. Our results indicated that high level of CD8+ cells infiltration in tumor stroma (TS) or tumor nest (TN) was associated with better OS in lung cancer patients (HR = 0.76, 95% CI 0.62-0.93, P = 0.006; HR = 0.80, 95% CI 0.67-0.96; P = 0.018, respectively). Similar results could be also observed in CD3+ T cells infiltration. High CD4+ T lymphocytes infiltration in TS was explicitly accompanied by better OS (HR = 0.65, 95% CI 0.46-0.91; P = 0.013), rather than in TN. In contrast, high density of FOXP3+ T cells infiltration in TS showed a poor PFS (HR = 2.67, 95% CI, 1.74-4.08, P < 0.001). Conclusion: This meta-analysis clarified that high level of CD8+ and CD3+ T cells infiltration in TS or TN, and high CD4+ T lymphocytes infiltration in TS showed better OS in lung cancer patients, whereas high density of FOXP3+ T cells infiltration in TS could be recognized as a negative prognostic factor.

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