Rapid tumor‐labeling kinetics with a site‐specific near‐infrared anti‐CEA nanobody in a patient‐derived orthotopic xenograft mouse model of colon cancer

2021 ◽  
Author(s):  
Thinzar M. Lwin ◽  
Michael A. Turner ◽  
Siamak Amirfakhri ◽  
Hiroto Nishino ◽  
Pieterjan Debie ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Mouse Model ◽  
Near Infrared ◽  
Site Specific ◽  
Xenograft Mouse Model ◽  
Orthotopic Xenograft ◽  
A Site

scholarly journals Evaluation of the antitumor effects of PP242 in a colon cancer xenograft mouse model using comprehensive metabolomics and lipidomics

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Md Mamunur Rashid ◽  
Hyunbeom Lee ◽  
Byung Hwa Jung
Keyword(s):  
Colon Cancer ◽  
Mouse Model ◽  
High Performance ◽  
Tca Cycle ◽  
Treated Group ◽  
Metabolic Changes ◽  
Antitumor Effects ◽  
Xenograft Mouse Model ◽  
Metabolic Mechanism ◽  
Comprehensive Metabolomics

Abstract PP242, an inhibitor of mechanistic target of rapamycin (mTOR), displays potent anticancer effects against various cancer types. However, the underlying metabolic mechanism associated with the PP242 effects is not clearly understood. In this study, comprehensive metabolomics and lipidomics investigations were performed using ultra-high-performance chromatography-Orbitrap-mass spectrometry (UHPLC-Orbitrap-MS) in plasma and tumor tissue to reveal the metabolic mechanism of PP242 in an LS174T cell-induced colon cancer xenograft mouse model. After 3 weeks of PP242 treatment, a reduction in tumor size and weight was observed without any critical toxicities. According to results, metabolic changes due to the effects of PP242 were not significant in plasma. In contrast, metabolic changes in tumor tissues were very significant in the PP242-treated group compared to the xenograft control (XC) group, and revealed that energy and lipid metabolism were mainly altered by PP242 treatment like other cancer inhibitors. Additionally, in this study, it was discovered that not only TCA cycle but also fatty acid β-oxidation (β-FAO) for energy metabolism was inhibited and clear reduction in glycerophospholipid was observed. This study reveals new insights into the underlying anticancer mechanism of the dual mTOR inhibitor PP242, and could help further to facilitate the understanding of PP242 effects in the clinical application.

scholarly journals Tumor-targetingSalmonella typhimuriumA1-R arrests a doxorubicin-resistant PDGFRA-amplified patient-derived orthotopic xenograft mouse model of pleomorphic liposarcoma

2018 ◽  
Vol 119 (9) ◽  
pp. 7827-7833 ◽  
Author(s):  
Tasuku Kiyuna ◽  
Yasunori Tome ◽  
Takashi Murakami ◽  
Ming Zhao ◽  
Kentaro Miyake ◽  
...  
Keyword(s):  
Mouse Model ◽  
Pleomorphic Liposarcoma ◽  
Xenograft Mouse Model ◽  
Orthotopic Xenograft
Sign in / Sign up

Export Citation Format

Share Document