Preoperative nomogram to predict posthepatectomy liver failure

2021 ◽  
Author(s):  
Mashaal Dhir ◽  
Kaeli K. Samson ◽  
Natesh Yepuri ◽  
Ujwal R. Yanala ◽  
Lynette M. Smith ◽  
...  
Keyword(s):  
Liver Failure ◽  
Posthepatectomy Liver Failure

scholarly journals Does Laparoscopic Liver Resection for Hepatocellular Carcinoma Reduce Posthepatectomy Liver Failure?

HPB ◽  
2021 ◽  
Vol 23 ◽  
pp. S159
Author(s):  
Y. Uemoto ◽  
K. Taura ◽  
T. Nishio ◽  
Y. Kimura ◽  
N. Nam ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Resection ◽  
Liver Failure ◽  
Laparoscopic Liver Resection ◽  
Posthepatectomy Liver Failure

scholarly journals Major Hepatectomy in a Child with Extremely Low Future Liver Remnant Without Posthepatectomy Liver Failure

HPB ◽  
2021 ◽  
Vol 23 ◽  
pp. S201
Author(s):  
D. Akhaladze ◽  
D. Kachanov ◽  
G. Rabaev ◽  
N. Merkulov ◽  
N. Uskova ◽  
...  
Keyword(s):  
Liver Failure ◽  
Major Hepatectomy ◽  
Future Liver Remnant ◽  
Liver Remnant ◽  
Posthepatectomy Liver Failure

scholarly journals Spleen stiffness and volume help to predict posthepatectomy liver failure in patients with hepatocellular carcinoma

Medicine ◽  
2019 ◽  
Vol 98 (18) ◽  
pp. e15458 ◽  
Author(s):  
Wei Peng ◽  
Xiao-Yun Zhang ◽  
Chuan Li ◽  
Tian-Fu Wen ◽  
Lv-Nan Yan ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Failure ◽  
Posthepatectomy Liver Failure ◽  
Spleen Stiffness

scholarly journals Predictive value of gadoxetic acid–enhanced MRI for posthepatectomy liver failure: a systematic review

2021 ◽  
Author(s):  
Qiang Wang ◽  
Anrong Wang ◽  
Ernesto Sparrelid ◽  
Jiaxing Zhang ◽  
Ying Zhao ◽  
...  
Keyword(s):  
Systematic Review ◽  
Liver Function ◽  
Liver Failure ◽  
Risk Of Bias ◽  
Gadoxetic Acid ◽  
Imaging Biomarker ◽  
Cochrane Library ◽  
Large Sample Size ◽  
Posthepatectomy Liver Failure ◽  
Enhanced Mri

Abstract   Objectives Effective and non-invasive biomarkers to predict and avoid posthepatectomy liver failure (PHLF) are urgently needed. This systematic review aims to evaluate the efficacy of gadoxetic acid–enhanced MRI-derived parameters as an imaging biomarker in preoperative prediction of PHLF. Methods A systematic literature search was performed in the databases of PubMed/Medline, Web of Science, Embase, and Cochrane Library up to 11 December 2020. Studies evaluating the incidence of PHLF on patients who underwent hepatectomy with preoperative liver function assessment using gadoxetic acid–enhanced MRI were included. Data was extracted using pre-designed tables. The Quality In Prognostic Studies (QUIPS) tool was adopted to evaluate the risk of bias. Results A total of 15 studies were identified for qualitative synthesis and most studies were marked as low to moderate risk of bias in each domain of QUIPS. The most commonly used parameter was relative liver enhancement or its related parameters. The reported incidence of PHLF ranged from 3.9 to 40%. The predictive sensitivity and specificity of gadoxetic acid–enhanced MRI parameters varied from 75 to 100% and from 54 to 93% in ten reported studies. A majority of the studies revealed that the gadoxetic acid–enhanced MRI parameter was a predictor for PHLF. Conclusions Gadoxetic acid–enhanced MRI showed a high predictive capacity for PHLF and represents a promising imaging biomarker in prediction of PHLF. Multicenter, prospective trials with large sample size and reliable, unified liver function parameters are required to validate the efficacy of individual liver function parameters. Key Points • There is an obvious heterogeneity of the published studies, not only in variance of MRI liver function parameters but also in indication and extent of the liver resection. • Signal intensity (SI)–based parameters derived from gadoxetic acid–enhanced MRI are the commonly used method for PHLF prediction. • Gadoxetic acid–enhanced MRI-derived parameters showed high predictive efficacy for PHLF and can potentially serve as a predictor for the incidence of PHLF.

scholarly journals Preoperative ICG Test to Predict Posthepatectomy Liver Failure and Postoperative Outcomes in Hilar Cholangiocarcinoma

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Min Li ◽  
Jie Wang ◽  
Jieqiong Song ◽  
Feng Shen ◽  
Lujun Song ◽  
...  
Keyword(s):  
Postoperative Complications ◽  
Liver Function ◽  
Liver Failure ◽  
Clinical Significance ◽  
Hilar Cholangiocarcinoma ◽  
Retention Rate ◽  
Univariate Analysis ◽  
Postoperative Outcomes ◽  
Posthepatectomy Liver Failure ◽  
Icg R15

Preoperative evaluation of hepatic functional reserve in patients with hilar cholangiocarcinoma (hCCA) has vital clinical significance for prevention of posthepatectomy liver failure (PHLF) and mortality. The aim of the present study was to evaluate the clinical significance of the indocyanine green retention rate at 15 minutes (ICG R15) and related factors of postoperative outcomes in patients with hCCA. 147 patients who scheduled for hCCA resection underwent a preoperative ICG test between May 2015 and May 2020 and were prospectively analyzed. Single-factor analysis was used to evaluate the risk factors for PHLF and postoperative outcomes in hCCA. After univariate analysis, significant differences in ICG R15 were found between the PHLF group and the liver function recovered well (LFRW) group ( P ≤ 0.05 ). In terms of postoperative complications, ICG R15 was also a risk factor for moderate-to-severe postoperative complications. Preoperative ICG R15 was significantly associated with PHLF and moderate-to-severe postoperative complications. ICG R15 may become an ideal clinical indicator for the evaluation of liver function reserve before hCCA and can better predict the postoperative complications.

Sign in / Sign up

Export Citation Format

Share Document