Prognostic Utility of Postoperative C-reactive Protein for Posthepatectomy Liver Failure—Invited Critique

2008 ◽  
Vol 143 (3) ◽  
pp. 253
Author(s):  
Christopher L. Wolfgang
Keyword(s):  
Liver Failure ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Posthepatectomy Liver Failure ◽  
Prognostic Utility

Prognostic utility of the semi-quantitative procalcitonin test, neutrophil count and C-reactive protein in meningococcal infection in children

2005 ◽  
Vol 165 (1) ◽  
pp. 26-29 ◽  
Author(s):  
Juan Casado-Flores ◽  
Alfredo Blanco-Quirós ◽  
Montserrat Nieto ◽  
Julia Asensio ◽  
Cristina Fernández
Keyword(s):  
Neutrophil Count ◽  
Meningococcal Infection ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Prognostic Utility

scholarly journals The prognostic impact of lymphocyte-to-C-reactive protein score in patients undergoing surgical resection for intrahepatic cholangiocarcinoma: A comparative study of major representative inflammatory / immunonutritional markers

PLoS ONE ◽  
2021 ◽  
Vol 16 (1) ◽  
pp. e0245946
Author(s):  
Daisuke Noguchi ◽  
Naohisa Kuriyama ◽  
Yuki Nakagawa ◽  
Koki Maeda ◽  
Toru Shinkai ◽  
...  
Keyword(s):  
Multivariate Analysis ◽  
Surgical Resection ◽  
Intrahepatic Cholangiocarcinoma ◽  
Prognostic Significance ◽  
Prognostic Indicator ◽  
Rank Test ◽  
Prognostic Impact ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Prognostic Utility

Background In many malignancies including intrahepatic cholangiocarcinoma (iCCA), prognostic significance of host-related inflammatory / immunonutritional markers have attracted a lot of attention. However, it is unclear which is the strongest prognostic indicator for iCCA among these markers. The aim of this study was to firstly evaluate the prognostic utility of inflammatory / immunonutritional markers in resected iCCA patients using a multiple comparison in addition to a new marker, lymphocyte-to-C-reactive protein (CRP) score. Methods A total of sixty iCCA patients, who underwent surgical resection between October 2004 and April 2019, were enrolled in this study. Their clinical and pathological data were retrospectively assessed using univariate and multivariate analysis to determine prognostic predictors for disease specific survival (DSS). Moreover, these patients, who were divided into high and low groups based on lymphocyte-to-CRP score, were compared these survival outcomes using Kaplan-Meier analysis with a log-rank test. Results In multivariate analysis, the significant prognostic factors were preoperative lymphocyte-to-CRP score (p = 0.008), preoperative CRP-to-albumin ratio (CAR; p = 0.017), pathological T category (p = 0.003), and pathological vascular invasion (p < 0.001). Resected iCCA patients with a low lymphocyte-to-CRP score (score 0) had significant better prognosis than patients with a high score (score 1 or 2) (p = 0.016). Notably, the mortality of the high lymphocyte-to-CRP score group did not show statistically difference from the poor mortality of unresected iCCA patients (p = 0.204). Conclusions Preoperative lymphocyte-to-CRP score was the strongest prognostic indicator in iCCA patients with surgical resection. In these patients, early intervention with nutritional support should be considered prior to operation.

PROGNOSTIC UTILITY OF FERRITIN AND C-REACTIVE PROTEIN IN SEPSIS

1998 ◽  
Vol 26 (Supplement) ◽  
pp. 131A
Author(s):  
Jorge Lopez-Martinez ◽  
Margarita Sanchez-Castilla ◽  
M Jose Jimenez-Martin ◽  
Alejandro Algora-Weber ◽  
Abelardo Garcia-de-Lorenzo ◽  
...  
Keyword(s):  
C Reactive Protein ◽  
Reactive Protein ◽  
Prognostic Utility

scholarly journals High-Sensitivity C-Reactive Protein: A Novel and Promising Marker of Coronary Heart Disease

2001 ◽  
Vol 47 (3) ◽  
pp. 403-411 ◽  
Author(s):  
Nader Rifai ◽  
Paul M Ridker
Keyword(s):  
Cardiovascular Disease ◽  
Acute Coronary Syndromes ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Prognostic Utility ◽  
Coronary Syndromes ◽  
Coronary Events ◽  
Hs Crp ◽  
Apparently Healthy

Abstract Background: Coronary heart disease remains the leading cause of morbidity and mortality in the industrialized world. Clinical and laboratory studies have shown that inflammation plays a major role in the initiation, progression, and destabilization of atheromas. C-Reactive protein (CRP), an acute phase reactant that reflects low-grade systemic inflammation, has been studied in a variety of cardiovascular diseases. Approach: Findings from prospective clinical trials were examined to determine the prognostic utility of CRP in acute coronary syndromes, and observations from epidemiological studies were reviewed to determine the ability of CRP to predict future first coronary events. The analytical considerations of CRP measurement in these clinical applications were also examined. Content: In patients with established coronary disease, CRP has been shown to predict adverse clinical events. In addition, prospective studies have consistently shown that CRP is a strong predictor of future coronary events in apparently healthy men and women. The relative risk associated with CRP is independent of other cardiovascular disease risk factors. High-sensitivity CRP (hs-CRP) assays are needed for risk assessment of cardiovascular disease. Such assays are currently available but may require further standardization because patients’ results will be interpreted using population-based cutpoints. Preventive therapies to attenuate coronary risk in individuals with increased hs-CRP concentrations include aspirin and statin-type drugs. Summary: hs-CRP has prognostic utility in patients with acute coronary syndromes and is a strong independent predictor of future coronary events in apparently healthy subjects.

scholarly journals The Potential Benefits of Renal Replacement Therapy in Combination with a Hemadsorption Column in Critically Ill Patients with Acute on Chronic Liver Failure

2020 ◽  
Author(s):  
Tomescu Dana ◽  
Mihai Popescu ◽  
Gheorghe Liliana ◽  
Iacob Speranța ◽  
Dima Simona ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Renal Replacement Therapy ◽  
Liver Failure ◽  
Replacement Therapy ◽  
Chronic Liver ◽  
C Reactive Protein ◽  
Chronic Liver Failure ◽  
Reactive Protein ◽  
Main Adverse Effect ◽  
Registration Number

Abstract Background. Acute on chronic liver failure (AoCLF) represents a life-threatening complication of liver cirrhosis with high mortality if patients cannot be bridged to emergency liver transplantation. The aim of this study was to assess clinical and paraclinical effects of renal replacement therapy (RRT) in combination with a hemadsorption column in patients with AoCLF. Methods. Patients were included in the study after Intensive Care Unit (ICU) admission and RRT in combination with CytoSorb® was started for three consecutive sessions. Clinical and paraclinical data were recorded before the first session and after the end of the third session. 28-days mortality was also noted. Results. Fourteen patients were included in the final data analysis. The use of CytoSorb® was associated with a decrease in bilirubin levels (p = 0.03) and creatinine (p = 0.02) and an increase in urine output (p = 0.02). Although we observed a significant decrease in platelet count (p = 0.05), no haemorrhagic complications were noted. C-Reactive Protein significantly decreased after the therapy (p = 0.05), but we did not observe a similar decrease in leucocyte count (p = 0.87) or procalcitonin levels (p = 0.18). Seven patients underwent emergency liver transplantation and survival was 100% in this group. Conclusion. The use of CytoSorb® was associated with an improvement in liver and renal functions and a decrease in C - Reactive Protein. Thrombocytopenia represents the main adverse effect of the therapy, but no haemorrhagic complications were recorded. In patients that could be bridged to liver transplantation, survival was 100%. Trial registration number: NCT04511507

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