The role of preoperative albumin‐bilirubin grade for oncological risk stratification in liver transplant patients with hepatocellular carcinoma

2019 ◽  
Vol 120 (7) ◽  
pp. 1126-1136 ◽  
Author(s):  
Arno Kornberg ◽  
Ulrike Witt ◽  
Martina Schernhammer ◽  
Jennifer Kornberg ◽  
Katharina Müller ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Risk Stratification ◽  
Liver Transplant ◽  
Transplant Patients ◽  
Preoperative Albumin

The interplay between gut microbiota and the immune system in liver transplant recipients and its role in infections

2021 ◽  
Author(s):  
Giuseppe Ancona ◽  
Laura Alagna ◽  
Andrea Lombardi ◽  
Emanuele Palomba ◽  
Valeria Castelli ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Immune System ◽  
Liver Disease ◽  
Gut Microbiota ◽  
Liver Transplant ◽  
Bacterial Infections ◽  
Multidrug Resistant ◽  
Transplant Recipients ◽  
Liver Transplant Recipients

Liver transplantation (LT) is a life-saving strategy for patients with end-stage liver disease, hepatocellular carcinoma and acute liver failure. LT success can be hampered by several short-term and long-term complications. Among them, bacterial infections, especially due to multidrug-resistant germs, are particularly frequent with a prevalence between 19 and 33% in the first 100 days after transplantation. In the last decades, a number of studies have highlighted how gut microbiota (GM) is involved in several essential functions to ensure the intestinal homeostasis, becoming one of the most important virtual metabolic organs. GM works through different axes with other organs, and the gut-liver axis is among the most relevant and investigated ones. Any alteration or disruption of GM is defined as dysbiosis. Peculiar phenotypes of GM dysbiosis have been associated to several liver conditions and complications, such as chronic hepatitis, fatty liver disease, cirrhosis and hepatocellular carcinoma. Moreover, there is growing evidence of the crucial role of GM in shaping the immune response, both locally and systemically, against pathogens. This paves the way to the manipulation of GM as a therapeutic instrument to modulate the infectious risk and outcome. In this minireview we provide an overview of the current understanding on the interplay between gut microbiota and the immune system in liver transplant recipients and the role of the former in infections.

scholarly journals Perioperative risk stratification of liver transplant patients using AIMS-65

HPB ◽  
2018 ◽  
Vol 20 ◽  
pp. S807-S808
Author(s):  
M.-E. Tun Abraham ◽  
S. Patel ◽  
C. Garcia-Ocha ◽  
M. Hilwa ◽  
A. Moustafa ◽  
...  
Keyword(s):  
Risk Stratification ◽  
Liver Transplant ◽  
Perioperative Risk ◽  
Transplant Patients

scholarly journals Safety and Yield of Diagnostic ERCP in Liver Transplant Patients with Abnormal Liver Function Tests

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Jayapal Ramesh ◽  
Nipun Reddy ◽  
Hwasoon Kim ◽  
Klaus Mönkemüller ◽  
Shyam Varadarajulu ◽  
...  
Keyword(s):  
Liver Function ◽  
Liver Transplant ◽  
Liver Function Tests ◽  
Abnormal Liver Function ◽  
Biliary Stones ◽  
Organ Rejection ◽  
Transplant Patients ◽  
Function Tests ◽  
Biliary Pathology

Background. Abnormal liver enzymes postorthotopic liver transplant (OLT) may indicate significant biliary pathology or organ rejection. There is very little known in the literature regarding the current role of diagnostic ERCP in this scenario. Aim. To review the utility of diagnostic ERCP in patients presenting with abnormal liver function tests in the setting of OLT. Methods. A retrospective review of diagnostic ERCPs in patients with OLT from 2002 to 2013 from a prospectively maintained, IRB approved database. Results. Of the 474 ERCPs performed in OLT patients, 210 (44.3%; 95% CI 39.8–48.8) were performed for abnormal liver function tests during the study period. Majority of patients were Caucasian (83.8%), male (62.4%) with median age of 55 years (IQR 48–62 years). Biliary cannulation was successful in 99.6% of cases and findings included stricture in 45 (21.4 %); biliary stones/sludge in 23 (11%); biliary dilation alone in 31 (14.8%); and normal in 91 (43.3%). Three (1.4%) patients developed mild, self-limiting pancreatitis; one patient (0.5%) developed cholangitis and two (1%) had postsphincterotomy bleeding. Multivariate analyses showed significant association between dilated ducts on imaging with a therapeutic outcome. Conclusion. Diagnostic ERCP in OLT patients presenting with liver function test abnormalities is safe and frequently therapeutic.

scholarly journals Transcriptome and Exome Analyses of Hepatocellular Carcinoma Reveal Patterns to Predict Cancer Recurrence in Liver Transplant Patients

2021 ◽  
Author(s):  
Silvia Liu ◽  
Michael A. Nalesnik ◽  
Aatur Singhi ◽  
Michelle A. Wood‐Trageser ◽  
Parmjeet Randhawa ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplant ◽  
Cancer Recurrence ◽  
Transplant Patients
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