Association Between ACOX1 and NRF1 Gene Expression and Hepatitis B and C Virus Infections and Hepatocellular Carcinoma in Liver Transplant Patients (Shiraz, Iran)

2021 ◽  
Author(s):  
Ehsan Nabi Abdolyousefi ◽  
Gholamreza Motalleb ◽  
Ramin Yaghobi
Keyword(s):  
Gene Expression ◽  
Hepatocellular Carcinoma ◽  
Hepatitis B ◽  
Liver Transplant ◽  
Virus Infections ◽  
Transplant Patients

scholarly journals Hepatitis B virus suppression predicts better recurrence-free survivals in liver transplant patients with hepatocellular carcinoma

2021 ◽  
Vol 35 (1) ◽  
pp. S161-S161
Author(s):  
Su Young Hong ◽  
Kwang-Woong Lee ◽  
Sola Lee ◽  
Sanggyun Suh ◽  
Eui Soo Han ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Liver Transplant ◽  
Transplant Patients ◽  
B Virus ◽  
Virus Suppression

scholarly journals Clinical features of hepatitis B and C virus infections, with high α-fetoprotein levels but not hepatocellular carcinoma

Medicine ◽  
2017 ◽  
Vol 96 (2) ◽  
pp. e5844 ◽  
Author(s):  
Cha Young Kim ◽  
Bo Ra Kim ◽  
Sang Soo Lee ◽  
Dae-Hong Jeon ◽  
Chang Min Lee ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis B ◽  
Clinical Features ◽  
Virus Infections

Nucleoside analog monotherapy for prophylaxis in Hepatitis B liver transplant patients is safe and efficacious

2020 ◽  
Vol 14 (1) ◽  
pp. 57-69 ◽  
Author(s):  
Mark D. Muthiah ◽  
En Ying Tan ◽  
Sin Hui Melissa Chua ◽  
Daniel Q. Y. Huang ◽  
Glenn K. Bonney ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Liver Transplant ◽  
Nucleoside Analog ◽  
Transplant Patients

A case-control study of hepatitis B and C virus infections in the etiology of hepatocellular carcinoma

1995 ◽  
Vol 60 (5) ◽  
pp. 627-631 ◽  
Author(s):  
Stephanos Hadziyannis ◽  
Edward Tabor ◽  
Evangclia Kaklamani ◽  
Anastasia Tzonou ◽  
Sherri Stuver ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis B ◽  
Case Control Study ◽  
Case Control ◽  
Virus Infections ◽  
Control Study

Hepatitis C Virus Reinfection in Orthotopic Liver Transplant Patients with or without Concomitant Hepatitis B Infection

1996 ◽  
Vol 5 (2) ◽  
pp. 81-87 ◽  
Author(s):  
Massimo Loda ◽  
Michelangelo Fiorentino ◽  
Jason Meckler ◽  
Urmila Khettry ◽  
David Lewis ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Hepatitis B ◽  
Liver Transplant ◽  
Orthotopic Liver Transplant ◽  
Hepatitis B Infection ◽  
Transplant Patients

scholarly journals Screening and Functional Prediction of Key Candidate Genes in Hepatitis B Virus-Associated Hepatocellular Carcinoma

2020 ◽  
Vol 2020 ◽  
pp. 1-13
Author(s):  
Xia Chen ◽  
Ling Liao ◽  
Yuwei Li ◽  
Hengliu Huang ◽  
Qing Huang ◽  
...  
Keyword(s):  
Gene Expression ◽  
Hepatocellular Carcinoma ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Pathway Analysis ◽  
Kegg Pathway ◽  
Metabolic Process ◽  
Hub Genes ◽  
Kegg Pathway Analysis ◽  
B Virus

Background. The molecular mechanism by which hepatitis B virus (HBV) induces hepatocellular carcinoma (HCC) is still unknown. The genomic expression profile and bioinformatics methods were used to investigate the potential pathogenesis and therapeutic targets for HBV-associated HCC (HBV-HCC). Methods. The microarray dataset GSE55092 was downloaded from the Gene Expression Omnibus (GEO) database. The data was analyzed by the bioinformatics software to find differentially expressed genes (DEGs). Gene Ontology (GO) enrichment analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, ingenuity pathway analysis (IPA), and protein-protein interaction (PPI) network analysis were then performed on DEGs. The hub genes were identified using Centiscape2.2 and Molecular Complex Detection (MCODE) in the Cytoscape software (Cytoscape_v3.7.2). The survival data of these hub genes was downloaded from the Gene Expression Profiling Interactive Analysis (GEPIA). Results. A total of 2264 mRNA transcripts were differentially expressed, including 764 upregulated and 1500 downregulated in tumor tissues. GO analysis revealed that these DEGs were related to the small-molecule metabolic process, xenobiotic metabolic process, and cellular nitrogen compound metabolic process. KEGG pathway analysis revealed that metabolic pathways, complement and coagulation cascades, and chemical carcinogenesis were involved. Diseases and biofunctions showed that DEGs were mainly associated with the following diseases or biological function abnormalities: cancer, organismal injury and abnormalities, gastrointestinal disease, and hepatic system disease. The top 10 upstream regulators were predicted to be activated or inhibited by Z-score and identified 25 networks. The 10 genes with the highest degree of connectivity were defined as the hub genes. Cox regression revealed that all the 10 genes (CDC20, BUB1B, KIF11, TTK, EZH2, ZWINT, NDC80, TPX2, MELK, and KIF20A) were related to the overall survival. Conclusion. Our study provided a registry of genes that play important roles in regulating the development of HBV-HCC, assisting us in understanding the molecular mechanisms that underlie the carcinogenesis and progression of HCC.

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