Previous radiation for prostate neoplasm alters surgical and oncologic outcomes after rectal cancer surgery

2015 ◽  
Vol 112 (8) ◽  
pp. 802-808 ◽  
Author(s):  
Marlène Guandalino ◽  
Aurélien Dupré ◽  
Marie François ◽  
Bertrand Leroy ◽  
Olivier Antomarchi ◽  
...  
2021 ◽  
Vol 34 (06) ◽  
pp. 431-438
Author(s):  
Deborah S. Keller ◽  
K. Talboom ◽  
C.P.M van Helsdingen ◽  
Roel Hompes

AbstractDespite advances in rectal cancer surgery, anastomotic leakage (AL) remains a common complication with a significant impact on patient recovery, health care costs, and oncologic outcomes. The spectrum of clinical severity associated with AL is broad, and treatment options are diverse with highly variable practices across the colorectal community. To be effective, the treatment must match not only the patient's current status but also the type of leak, the surgeon's skill, and the resources available. In this chapter, we will review the current and emergent treatment modalities for AL after rectal cancer surgery.


2011 ◽  
Vol 96 (2) ◽  
pp. 120-126 ◽  
Author(s):  
Art Hiranyakas ◽  
Yik-Hong Ho

Abstract The rapid in development of surgical technology has had a major effect in surgical treatment of colorectal cancer. Laparoscopic colon cancer surgery has been proven to provide better short-term clinical and oncologic outcomes. However this quickly accepted surgical approach is still performed by a minority of colorectal surgeons. The more technically challenging procedure of laparoscopic rectal cancer surgery is also on its way to demonstrating perhaps similar short-term benefits. This article reviews current evidences of both short-term and long-term outcomes of laparoscopic colorectal cancer surgery, including the overall costs comparison between laparoscopic surgery and conventional open surgery. In addition, different surgical techniques for laparoscopic colon and rectal cancer are compared. Also the relevant future challenge of colorectal cancer robotic surgery is reviewed.


Surgery ◽  
2015 ◽  
Vol 158 (2) ◽  
pp. 453-459 ◽  
Author(s):  
Emily F. Midura ◽  
Dennis J. Hanseman ◽  
Richard S. Hoehn ◽  
Bradley R. Davis ◽  
Daniel E. Abbott ◽  
...  

2020 ◽  
Vol 38 (4_suppl) ◽  
pp. 41-41
Author(s):  
Adriana C. Gamboa ◽  
Rachel M. Lee ◽  
Michael K. Turgeon ◽  
Christopher Varlamos ◽  
Scott E. Regenbogen ◽  
...  

41 Background: Postoperative complications (POCs) are associated with worse oncologic outcomes in several cancer types. The implications of complications after rectal cancer surgery are not known. Methods: The US Rectal Cancer Consortium (2007-17) was reviewed for patients with primary rectal adenocarcinoma who underwent R0/R1 low anterior resection (LAR) or abdominoperineal resection (APR). 90-day POCs were categorized as major vs minor and grouped into infectious, cardiopulmonary (CP), thromboembolic (TE), renal, or intestinal dysmotility. Primary outcomes were 5-yr overall survival (OS) and recurrence-free survival (RFS). Results: Of 1136 pts, median age was 59 yrs (IQR 51-67), 61% were male (n = 693), median f/u was 31 mos (IQR 13-54). 70% underwent LAR (n = 799) and 30% APR (n = 337). Complication rate was 46% (n = 527), with 63% minor (n = 330) and 32% major (n = 170). Of all POCs, infectious complications comprised 20% (n = 105), cardiopulmonary 3% (n = 14), thromboembolic 5% (n = 25), renal 9% (n = 46) and intestinal dysmotility 19% (n = 100). When compared to minor or no POCs, major POCs were associated with both worse RFS (48 vs 63 vs 76% p < 0.01) and OS (64 vs 76 vs 80% p < 0.01). While a single POC was associated with worse RFS (61 vs 76% p < 0.01), multiple POCs were associated with worse OS (62% vs 79% p = 0.02). Regardless of complication grade, infectious POCs were associated with worse RFS (56 vs 76% p < 0.01) while CP and TE POCs were associated with worse OS (CP 40 vs 78% p < 0.01; TE 63 vs 78% p < 0.01). Postoperative renal dysfunction was associated with both worse RFS (26 vs 76%, p < 0.001) and OS (62 vs 78% p = 0.01). This persisted on MV analysis for OS when accounting for pathologic stage, receipt of neoadjuvant therapy, and final margin status (CP: HR 3.6 p = 0.01; TE: HR 19.4 p < 0.01; renal: HR 2.4 p = 0.01) and for RFS (infectious: HR 2.1 p < 0.01; renal: HR 3.2 p < 0.01). Conclusions: Major complications after proctectomy for cancer are associated with decreased recurrence-free and overall survival. Given the association of infectious complications and postoperative renal dysfunction with earlier recurrence of disease, efforts must be directed towards defining best practices and standardizing care.


Author(s):  
Adriana C. Gamboa ◽  
Rachel M. Lee ◽  
Michael K. Turgeon ◽  
Christopher Varlamos ◽  
Scott E. Regenbogen ◽  
...  

Endoscopy ◽  
2004 ◽  
Vol 36 (10) ◽  
Author(s):  
AL Gidwani ◽  
RS Date ◽  
D Hughes ◽  
P Neilly ◽  
R Gilliland

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