Impact of delayed lymphoscintigraphy for sentinel lymphnode biopsy for breast cancer

2015 ◽  
Vol 111 (8) ◽  
pp. 931-934 ◽  
Author(s):  
Hanghang Wang ◽  
Karissa Heck ◽  
Scott K. Pruitt ◽  
Terence Z. Wong ◽  
Randall P. Scheri ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Sentinel Lymphnode Biopsy

Sentinel-Lymphnode Biopsy in primary breast cancer: 99mTc versus ICG—A prospective, randomized trial.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. 575-575
Author(s):  
Peter Kern ◽  
Ann-Kathrin Bittner ◽  
Oliver Hoffmann ◽  
Rainer Kimmig ◽  
Ariane Schoffer ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Randomized Trial ◽  
Primary Breast Cancer ◽  
Near Infrared ◽  
Reference Method ◽  
Prospective Randomized Trial ◽  
Infrared Light ◽  
Study Cohort ◽  
Preparation Time ◽  
Sentinel Lymphnode Biopsy

575 Background: Sentinel-Lymphnode Biopsy (SLNB) is the standard procedure in primary breast cancer, routinely performed with 99mTechnetium radioactive tracers. Awareness of nuclear waste, costs and time consumption lead to the desire of breast surgeons to find safe and effective alternative options for detection of sentinel lymph nodes (SLN) in breast cancer and melanoma. Indocyaningreen is a tracer which emits fluorescence with near-infrared light of 780-810 nm when injected in the peritumoral or periareolar region, enabling surgeons to detect SLN and lymphatic pathways at the breast. Methods: We performed a prospective, randomized trial with patients with primary breast cancer. Both detection methods have been applied to patients of the study cohort comparing the preparation time, time to identify, concordance of the two methods and costs. Reference method was preoperative lymphszintigraphy. Results: 55 patients have been analyzed in this first report. Preparation time was 75,8 min (range 60-120 min) for 99mTc-tracer and a standard of 20 min for ICG. Time to identify SLN at a mean of 3,8 min(range 1-15 min) for 99mTc and 3 min (range 1-8 min) for ICG. Concordance rates were 98,2 % for the 1st SLN, 93,8 % both for 2nd and 3rd SLN. After neoadjuvant chemotherapy, all SLN have been been detected by both techniques, in 3 patients additional SLN have been found by ICG. Costs have been cut down to 1/10 with the use of ICG, coming up to saving of 27 000 US-$ per each 100 SLNB procedures performed. Conclusions: We report a high concordance rate between the 2 techniques - 99mTechnetium and ICG with near-infrared - for detection of SLN in breast cancer. Preparation time is cut down to less than 30 %, and costs to less the 10 % of radioactive labelling. Clinical trial information: 18-8054-BO .

scholarly journals Sentinel lymphnode in breast cancer: an experience with 53 cases

2007 ◽  
Vol 50 (spe) ◽  
pp. 45-47
Author(s):  
Benedita Andrade Leal de Abreu ◽  
Nayana Alves de Brito Melo ◽  
Evandro Leal de Abreu ◽  
Carlos Sabas Vieira ◽  
Everardo Leal de Abreu
Keyword(s):  
Breast Cancer ◽  
Breast Carcinoma ◽  
Medical Literature ◽  
Current Medical ◽  
Sentinel Lymphnode Biopsy ◽  
Current Medical Literature

The value of sentinel lymphnode biopsy or selective linfadenectomy in assessing axillary status in breast carcinoma is well established in medical literature. This work presents a briefy study from our preliminary experience with 53 patients submitted to pre-surgical limphoscintigraphy and intraoperatory detection of sentinel lymphnode and compares our records with those of current medical literature.

scholarly journals Sentinel lymphnode biopsy in early breast cancer using methylene blue dye and radioactive sulphur colloid — a single institution Indian experience

2008 ◽  
Vol 70 (3) ◽  
pp. 111-119 ◽  
Author(s):  
S. P. Somashekhar ◽  
S. Zaveri Shabber ◽  
K. Udupa Venkatesh ◽  
K. Venkatachala ◽  
Parameshwaran ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Methylene Blue ◽  
Early Breast Cancer ◽  
Blue Dye ◽  
Methylene Blue Dye ◽  
Single Institution ◽  
Indian Experience ◽  
Sentinel Lymphnode Biopsy

Virus-Like Particles in a Human Breast Cancer: Structural Similarity to Previously Reported Particles

1973 ◽  
Vol 31 ◽  
pp. 378-379
Author(s):  
G. Kasnic ◽  
S. E. Stewart ◽  
C. Urbanski
Keyword(s):  
Breast Cancer ◽  
Biological Activity ◽  
Human Breast Cancer ◽  
Osteogenic Sarcoma ◽  
Human Tumor ◽  
Structural Similarity ◽  
Cell Tumor ◽  
Human Breast ◽  
Human Tumor Cell ◽  
Type Particle

We have reported the maturation of an intracisternal A-type particle in murine plasma cell tumor cultures and three human tumor cell cultures (rhabdomyosarcoma, lung adenocarcinoma, and osteogenic sarcoma) after IUDR-DMSO activation. In all of these studies the A-type particle seems to develop into a form with an electron dense nucleoid, presumably mature, which is also intracisternal. A similar intracisternal A-type particle has been described in leukemic guinea pigs. Although no biological activity has yet been demonstrated for these particles, on morphologic grounds, and by the manner in which they develop within the cell, they may represent members of the same family of viruses.

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