Lysophosphatidic acid (LPA) and endothelial differentiation gene (Edg) receptors in human pancreatic cancer

2011 ◽  
Vol 104 (6) ◽  
pp. 685-691 ◽  
Author(s):  
G.M. LV ◽  
P. Li ◽  
W.D. Wang ◽  
Sh.K. Wang ◽  
J.F. Chen ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Lysophosphatidic Acid ◽  
Human Pancreatic Cancer ◽  
Endothelial Differentiation ◽  
Edg Receptors ◽  
Differentiation Gene

scholarly journals Lysophosphatidic Acid (LPA) in Malignant Ascites Stimulates Motility of Human Pancreatic Cancer Cells through LPA1

2003 ◽  
Vol 279 (8) ◽  
pp. 6595-6605 ◽  
Author(s):  
Takayuki Yamada ◽  
Koichi Sato ◽  
Mayumi Komachi ◽  
Enkhzol Malchinkhuu ◽  
Masayuki Tobo ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Cells ◽  
Lysophosphatidic Acid ◽  
Malignant Ascites ◽  
Human Pancreatic Cancer ◽  
Pancreatic Cancer Cells

scholarly journals Hepatic Oval (Stem) Cell Expression of Endothelial Differentiation Gene Receptors for Lysophosphatidic Acid in Mouse Chronic Liver Injury

2002 ◽  
Vol 11 (4) ◽  
pp. 643-649 ◽  
Author(s):  
Yuri Y. Sautin ◽  
Marda Jorgensen ◽  
Bryon E. Petersen ◽  
Jean S. Saulnier-Blache ◽  
James M. Crawford ◽  
...  
Keyword(s):  
Stem Cell ◽  
Liver Injury ◽  
Lysophosphatidic Acid ◽  
Chronic Liver ◽  
Endothelial Differentiation ◽  
Chronic Liver Injury ◽  
Cell Expression ◽  
Differentiation Gene

scholarly journals Endothelial Differentiation Gene-2 Receptor Is Involved in Lysophosphatidic Acid-dependent Control of 3T3F442A Preadipocyte Proliferation and Spreading

2001 ◽  
Vol 276 (15) ◽  
pp. 11599-11605 ◽  
Author(s):  
Céline Pagès ◽  
Danièle Daviaud ◽  
Songzhu An ◽  
Stéphane Krief ◽  
Max Lafontan ◽  
...  
Keyword(s):  
Lysophosphatidic Acid ◽  
Significant Contribution ◽  
Cell Spreading ◽  
Endothelial Differentiation ◽  
Receptor Subtype ◽  
Strong Reduction ◽  
Chain Reaction ◽  
Biological Responses ◽  
Polymerase Chain ◽  
Differentiation Gene

EDG-2,EDG-4,EDG-7, andPSP24genes encode distinct lysophosphatidic acid (LPA) receptors. The aim of the present study was to determine which receptor subtype is involved in the biological responses generated by LPA in preadipocytes. Growing 3T3F442A preadipocytes expressEDG-2andEDG-4mRNAs, with no expression ofEDG-7orPSP24mRNAs. Quantitative reverse transcriptase-polymerase chain reaction revealed thatEDG-2transcripts were 10-fold more abundant than that ofEDG-4. To determine the involvement of theEDG-2receptor in the responses of growing preadipocytes to LPA, stable transfection of antisenseEDG-2cDNA was performed in growing 3T3F442A preadipocytes. This procedure, led to a significant and specific reduction inEDG-2mRNA and protein. This was associated with a significant alteration in the effect of LPA on both cell proliferation and cell spreading. Finally, the differentiation of growing preadipocytes into quiescent adipocytes led to a strong reduction in the level ofEDG-2transcripts. Results demonstrate the significant contribution of the EDG-2 receptor in the biological responses generated by LPA in 3T3F442A preadipocytes.

scholarly journals Subtype-specific Residues Involved in Ligand Activation of the Endothelial Differentiation Gene Family Lysophosphatidic Acid Receptors

2008 ◽  
Vol 283 (18) ◽  
pp. 12175-12187 ◽  
Author(s):  
William J. Valentine ◽  
James I. Fells ◽  
Donna H. Perygin ◽  
Sana Mujahid ◽  
Kazuaki Yokoyama ◽  
...  
Keyword(s):  
Gene Family ◽  
Lysophosphatidic Acid ◽  
Endothelial Differentiation ◽  
Ligand Activation ◽  
Differentiation Gene ◽  
Lysophosphatidic Acid Receptors

In Vitro and In Vivo Antitumor Efficacy of Docetaxel and Sorafenib Combination in Human Pancreatic Cancer Cells

2010 ◽  
Vol 999 (999) ◽  
pp. 1-11
Author(s):  
P. Ulivi ◽  
C. Arienti ◽  
W. Zoli ◽  
M. Scarsella ◽  
S. Carloni ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Cells ◽  
Antitumor Efficacy ◽  
Human Pancreatic Cancer ◽  
Pancreatic Cancer Cells
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