Outcome after surgical treatment of suspected gastrointestinal stromal tumors involving the duodenum: Is limited resection appropriate?

2008 ◽  
Vol 97 (5) ◽  
pp. 388-391 ◽  
Author(s):  
Brian K.P. Goh ◽  
Pierce K.H. Chow ◽  
Sittampalam Kesavan ◽  
Wai-Ming Yap ◽  
Wai-Keong Wong
Keyword(s):  
Surgical Treatment ◽  
Gastrointestinal Stromal Tumors ◽  
Limited Resection ◽  
Stromal Tumors

Gastrointestinal Stromal Tumors: A “Benign” Tumor with Hepatic Metastasis after 11 Years

1998 ◽  
Vol 84 (1) ◽  
pp. 78-81 ◽  
Author(s):  
Carlo Ballarini ◽  
Mattia Intra ◽  
Andrea Pisani Ceretti ◽  
Francesco Prestipino ◽  
Filippo Maria Bianchi ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Hepatic Metastasis ◽  
Tumor Size ◽  
Gastrointestinal Stromal Tumors ◽  
Cellular Proliferation ◽  
Malignant Potential ◽  
Mitotic Count ◽  
Proliferation Index ◽  
Ki 67 ◽  
Stromal Tumors

Gastrointestinal stromal tumors (GIST) constitue the largest category of primary non-epithelial neoplasms of the stomach and small bowel. They are characterized by a remarkable cellular variability and their malignant potential is sometimes difficult to predict. Very recent studies, using mitotic count and tumor size as the best determinants of biological behavior, divide GISTs into three groups: benign, borderline and malignant tumors. We report on a male patient who underwent a right hepatectomy for a large metastasis 11 years after the surgical treatment of an antral-pyloric gastric neoplasm, histologically defined as leiomyoblastoma and with clinical, morphological and immunohistochemical features of benignity (low mitotic count, tumor size < 5 cm, low cellular proliferation index). Histological and immunohistochemical analysis of the hepatic metastasis showed the cellular proliferation index (Ki-67) to be positive in 25% of neoplastic cells, as opposed to the primary gastric tumor in which Ki-67 was positive in only 5% of neoplastic cells. In conclusion, although modern immunohistochemical techniques are now available to obtain useful prognostic information, the malignant potential of GISTs is sometimes difficult to predict: neoplasms clinically and histologically defined as benign could metastasize a long time after oncologically correct surgical treatment. Therefore, benign GISTs also require consistent, long-term follow-up.

scholarly journals Technical success and short-term results of surgical treatment of gastrointestinal stromal tumors: an experience of three centers

2017 ◽  
Vol 2 (6) ◽  
pp. 56-56 ◽  
Author(s):  
Mark Igorevich Gluzman ◽  
Victor Anatolevich Kashchenko ◽  
Aleksei Mikhailovich Karachun ◽  
Rashida Vakhidovna Orlova ◽  
Iakov Aleksandrovich Nakatis ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Gastrointestinal Stromal Tumors ◽  
Technical Success ◽  
Short Term ◽  
Stromal Tumors

Monitoring circulating tumor-DNA during surgical treatment in patients with gastrointestinal stromal tumors

2021 ◽  
pp. molcanther.0403.2021
Author(s):  
Gustav Johansson ◽  
Marta Berndsen ◽  
Stefan Lindskog ◽  
Tobias Österlund ◽  
Henrik Fagman ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Gastrointestinal Stromal Tumors ◽  
Circulating Tumor Dna ◽  
Stromal Tumors ◽  
Tumor Dna

scholarly journals Investigation of the factors influencing surgical treatment of duodenal gastrointestinal stromal tumors

2021 ◽  
Vol 13 (8) ◽  
pp. 959-969
Author(s):  
Yun-Zi Wu ◽  
Yang Li ◽  
Ming Wu ◽  
Xiao-Hao Zheng ◽  
Yan-Tao Tian ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Gastrointestinal Stromal Tumors ◽  
Stromal Tumors ◽  
Factors Influencing

Surgical treatment for gastrointestinal stromal tumors in children

2017 ◽  
Vol 6 (6) ◽  
pp. 38
Author(s):  
A. B. Ryabov ◽  
I. V. Poddubnyi ◽  
V. O. Trunov ◽  
M. Yu. Kozlov ◽  
I. V. Kolobaev ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Gastrointestinal Stromal Tumors ◽  
Stromal Tumors

Clinicopathological Characteristics, Surgical Treatments, and Survival Outcomes of Patients with Duodenal Gastrointestinal Stromal Tumor

2018 ◽  
Vol 36 (3) ◽  
pp. 206-217 ◽  
Author(s):  
Shuisheng Zhang ◽  
Yuan Tian ◽  
Yingtai Chen ◽  
Jianwei Zhang ◽  
Cuiling Zheng ◽  
...  
Keyword(s):  
Overall Survival ◽  
Gastrointestinal Stromal Tumors ◽  
Survival Rates ◽  
Progression Free Survival ◽  
Small Sample ◽  
Limited Resection ◽  
Survival Outcomes ◽  
Free Survival ◽  
Stromal Tumors ◽  
Duodenal Gists

Background: Duodenal gastrointestinal stromal tumors (GISTs) are rare and their clinicopathological features have not been completely described. In this retrospective study, we examined the characteristics and long-term outcomes of patients who underwent surgical treatment for duodenal GISTs. Methods: We examined patients surgically treated for duodenal GISTs from 1999 to 2016 at the China National Cancer Center. We analyzed patient characteristics, treatments, histological examinations, and survival outcomes. Results: The 52 surgeries performed included 14 pancreaticoduodenectomies (26.9%), 37 limited resections (71.2%), and one palliative bypass procedure (1.9%). No surgery-related death occurred. The complication rate in patients who underwent pancreaticoduodenectomy was slightly higher than that in patients who underwent limited resection. The 5-year overall survival and progression-free survival rates for patients with duodenal adenocarcinoma were 89.1 and 72.9%, respectively. The overall survival and progression-free survival rates were not significantly related to surgical methods. Large tumor size and high mitotic rate were associated with poor overall survival outcomes. However, no independent factor was associated with prognosis, which may be due to the small sample size. Conclusion: The prognosis of duodenal gastrointestinal stromal tumors was good. Limited resection seems to be oncologically feasible, with outcomes being less worse than those of pancreaticoduodenectomy.

scholarly journals Surgical treatment of gastrointestinal stromal tumors of the duodenum: a literature review

2018 ◽  
Vol 3 ◽  
pp. 71-71 ◽  
Author(s):  
Georgi Popivanov ◽  
Mihail Tabakov ◽  
George Mantese ◽  
Roberto Cirocchi ◽  
Irene Piccinini ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Literature Review ◽  
Gastrointestinal Stromal Tumors ◽  
Stromal Tumors
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