Hypoglycemic effect of hawthorn in type II diabetes mellitus rat model

2017 ◽  
Vol 97 (13) ◽  
pp. 4557-4561 ◽  
Author(s):  
Aili Aierken ◽  
Tina Buchholz ◽  
Chen Chen ◽  
Xiaoying Zhang ◽  
Matthias F Melzig
Keyword(s):  
Diabetes Mellitus ◽  
Rat Model ◽  
Type Ii Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
Hypoglycemic Effect ◽  
Type Ii

scholarly journals Synergistic Hypoglycemic Effects of Pumpkin Polysaccharides and Puerarin on Type II Diabetes Mellitus Mice

Molecules ◽  
2019 ◽  
Vol 24 (5) ◽  
pp. 955 ◽  
Author(s):  
Xue Chen ◽  
Lei Qian ◽  
Bujiang Wang ◽  
Zhijun Zhang ◽  
Han Liu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type Ii Diabetes ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Type Ii Diabetes Mellitus ◽  
Hypoglycemic Effect ◽  
Lipid Lowering ◽  
Heme Oxygenase 1 ◽  
Related Factor ◽  
Type Ii

To investigate the hypoglycemic effect and potential mechanism of pumpkin polysaccharides and puerarin on type II diabetes mellitus (T2DM) mice, mice were fed a high-fat diet and injected intraperitoneally with streptozotacin to induce T2DM. After eight weeks of drug administration, blood samples were withdrawn from tail veins of mice that had been fasted overnight. The results showed that both pumpkin polysaccharides and puerarin, as well as a pumpkin polysaccharides and puerarin combination, could ameliorate T2DM. The pumpkin polysaccharides and puerarin combination had a synergetic hypoglycemic effect on T2DM mice that was greater than the pumpkin polysaccharides’ or the puerarin’s hypoglycemic effect. Both the pumpkin polysaccharides and the puerarin were found to ameliorate the blood glucose tolerance and insulin resistance of T2DM mice. They showed lipid-lowering activity by reducing the total cholesterol, triglycerides, and low-density lipoprotein levels, and improving the high-density lipoprotein level. They had beneficial effects on the oxidative stress by decreasing the reactive oxygen species and malondialdehyde levels, and increasing the glutathione level and the superoxide dismutase activity. Furthermore, the nuclear factor E2 related factor 2 (Nrf2), heme oxygenase-1, and phosphoinositide-3-kinase (PI3K) levels were upregulated, and the Nrf2 and PI3K signalling pathways might be involved in the hypoglycemic mechanism. The combined administration of pumpkin polysaccharides and puerarin could synergistically ameliorate T2DM.

scholarly journals The ameliorative activity of Chrysobalanus orbicularis in streptozotocin-induced type II diabetes mellitus rat model

Heliyon ◽  
2021 ◽  
Vol 7 (4) ◽  
pp. e06596
Author(s):  
Lisa Ilobekemen Ekakitie ◽  
Babatunji Emmanuel Oyinloye ◽  
Basiru Olaitan Ajiboye
Keyword(s):  
Diabetes Mellitus ◽  
Rat Model ◽  
Type Ii Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii

scholarly journals Repaglinide is a new oral sugar-lowering drug in the treatment of type II diabetes mellitus

1999 ◽  
Vol 45 (4) ◽  
pp. 40-45
Author(s):  
M. I. Balabolkin
Keyword(s):  
Diabetes Mellitus ◽  
Pancreatic Islets ◽  
Type Ii Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
Main Group ◽  
Hypoglycemic Effect ◽  
Type Ii ◽  
Lowering Drug ◽  
Stimulation Of

Sulfonylureas are the main group of drugs used to treat type II diabetes mellitus. These drugs belong to insulin secretogens and their main hypoglycemic effect is associated with stimulation of the formation and release of insulin from pancreatic islets.

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