Evaluation of toxicological impacts on Sprague-Dawley rat by successively low dose of aflatoxin B1

2014 ◽  
Vol 94 (14) ◽  
pp. 3017-3022 ◽  
Author(s):  
Wei Wei ◽  
Rui Li ◽  
Liang He ◽  
Xu Wang ◽  
Xiaofeng Ji ◽  
...  
Keyword(s):  
Aflatoxin B1 ◽  
Low Dose ◽  
Sprague Dawley ◽  
Sprague Dawley Rat

scholarly journals Development of HFD‐Fed /Low‐Dose STZ‐ Treated Female Sprague‐Dawley Rat Model to Investigate Diabetic Bone Fragility at Different Organization Levels

JBMR Plus ◽  
2020 ◽  
Vol 4 (10) ◽  
Author(s):  
Praveer Sihota ◽  
Ram Naresh Yadav ◽  
Sumathi Poleboina ◽  
Vishwajeet Mehandia ◽  
Sanjay Kumar Bhadada ◽  
...  
Keyword(s):  
Rat Model ◽  
Low Dose ◽  
Bone Fragility ◽  
Sprague Dawley ◽  
Sprague Dawley Rat

scholarly journals Correction: Long-term transcriptomic and proteomic effects in Sprague Dawley rat thyroid and plasma after internal low dose 131I exposure

PLoS ONE ◽  
2021 ◽  
Vol 16 (10) ◽  
pp. e0259429
Author(s):  
Malin Larsson ◽  
Nils Rudqvist ◽  
Johan Spetz ◽  
Emman Shubbar ◽  
Toshima Z. Parris ◽  
...  
Keyword(s):  
Low Dose ◽  
Sprague Dawley ◽  
Sprague Dawley Rat ◽  
Rat Thyroid

PKC activates BKCa channels in rat pulmonary arterial smooth muscle via cGMP-dependent protein kinase

2004 ◽  
Vol 286 (6) ◽  
pp. L1275-L1281 ◽  
Author(s):  
Scott A. Barman ◽  
Shu Zhu ◽  
Richard E. White
Keyword(s):  
Smooth Muscle ◽  
Protein Kinase ◽  
Channel Activity ◽  
Sprague Dawley ◽  
Dependent Protein Kinase ◽  
Pulmonary Vasoconstriction ◽  
Sprague Dawley Rat ◽  
Dependent Protein ◽  
Pulmonary Arterial ◽  
Pulmonary Arterial Smooth Muscle

Normally, signaling mechanisms that activate large-conductance, calcium- and voltage-activated potassium (BKCa) channels in pulmonary vascular smooth muscle cause pulmonary vasodilatation. BKCa-channel modulation is important in the regulation of pulmonary arterial pressure, and inhibition (decrease in the opening probability) of the BKCa channel has been implicated in the development of pulmonary vasoconstriction. Protein kinase C (PKC) causes pulmonary vasoconstriction, but little is known about the effect of PKC on BKCa-channel activity in pulmonary vascular smooth muscle. Accordingly, studies were done to determine the effect of PKC on BKCa-channel activity using patch-clamp studies in pulmonary arterial smooth muscle cells (PASMCs) of the Sprague-Dawley rat. The PKC activators phorbol myristate acetate (PMA) and thymeleatoxin opened BKCa channels in single Sprague-Dawley rat PASMC. The activator response to both PMA and thymeleatoxin on BKCa-channel activity was blocked by Gö-6983, which selectively blocks PKC-α, -δ, -γ, and -ζ, and by rottlerin, which selectively inhibits PKC-δ. In addition, the specific cyclic GMP-dependent protein kinase antagonist KT-5823 blocked the responses to PMA and thymelatoxin, whereas the specific cyclic AMP-dependent protein kinase blocker KT-5720 had no effect. In isolated pulmonary arterial vessels, both PMA and forskolin caused vasodilatation, which was inhibited by KT-5823, Gö-6983, or the BKCa-channel blocker tetraethylammonium. The results of this study indicate that activation of specific PKC isozymes increases BKCa-channel activity in Sprague-Dawley rat PASMC via cyclic GMP-dependent protein kinase, which suggests a unique signaling mechanism for vasodilatation.

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