scholarly journals Development of HFD‐Fed /Low‐Dose STZ‐ Treated Female Sprague‐Dawley Rat Model to Investigate Diabetic Bone Fragility at Different Organization Levels

JBMR Plus ◽  
2020 ◽  
Vol 4 (10) ◽  
Author(s):  
Praveer Sihota ◽  
Ram Naresh Yadav ◽  
Sumathi Poleboina ◽  
Vishwajeet Mehandia ◽  
Sanjay Kumar Bhadada ◽  
...  
Keyword(s):  
Rat Model ◽  
Low Dose ◽  
Bone Fragility ◽  
Sprague Dawley ◽  
Sprague Dawley Rat

scholarly journals Acute Histopathologic Findings Related to Needle Puncture Trauma during Subcutaneous Injection in the Sprague-Dawley Rat Model

2018 ◽  
Vol 47 (1) ◽  
pp. 93-96 ◽  
Author(s):  
Yuval Ramot ◽  
Kamala Kannan ◽  
Sathish Reddy ◽  
H. Krishnappa ◽  
John E. Dillberger ◽  
...  
Keyword(s):  
Rat Model ◽  
Normal Saline ◽  
Subcutaneous Injection ◽  
Needle Puncture ◽  
Sprague Dawley ◽  
Injection Site Reactions ◽  
Sprague Dawley Rat ◽  
Specific Time Point ◽  
Histopathologic Findings ◽  
Time Point

It is important to detect injection site reactions during the nonclinical phases of drug development. However, differentiating between normal changes following needle trauma and changes due to the toxicity of injected drugs can be challenging. Therefore, we used the Sprague-Dawley rat model to evaluate the pathological findings expected following a single subcutaneous injection of normal saline. Rats were subcutaneously administered with normal saline, and the injection sites were examined microscopically. Inflammation was evident in most of the injection sites, mostly in minimal severity. Parakeratosis/epithelial crust was also seen in several sites, and necrosis was observed in a minority of the cases. These findings indicate that needle puncture trauma can present with some degree of inflammation and necrosis. Although limited to a specific time point and strain, this study shows that inflammation following subcutaneous injection can be attributed in part to the needle trauma and not necessarily to the drug itself.

Protective Effect of Madhuca longifolia Leaves in 7, 12-Dimethylbenz(a)anthracene Induced Mammary Carcinoma in Sprague Dawley Rat model

2019 ◽  
Vol 15 (66) ◽  
pp. 396
Author(s):  
Maheswari Chinnadhurai ◽  
Faisal Al-Otaibi ◽  
Kenneth Nelson ◽  
Geetha Kandasamy ◽  
Meena Shanmugam ◽  
...  
Keyword(s):  
Protective Effect ◽  
Rat Model ◽  
Mammary Carcinoma ◽  
Sprague Dawley ◽  
Sprague Dawley Rat ◽  
Madhuca Longifolia

scholarly journals Effects of anti-obesity drugs, phentermine and mahuang, on the behavioral patterns in Sprague-Dawley rat model

2014 ◽  
Vol 30 (2) ◽  
pp. 73 ◽  
Author(s):  
Ryeo-Eun Go ◽  
Kyung-A Hwang ◽  
Seung-Hee Kim ◽  
Min-Young Lee ◽  
Cho-Won Kim ◽  
...  
Keyword(s):  
Rat Model ◽  
Behavioral Patterns ◽  
Sprague Dawley ◽  
Sprague Dawley Rat ◽  
Obesity Drugs

Complete sequence of a cholangiocarcinoma inbred Sprague-Dawley rat model mitochondrial genome

2014 ◽  
pp. 1-2
Author(s):  
Ai-Hua Luo ◽  
Gao-Feng Zhang ◽  
Yi-Fa Yin ◽  
Xin Li ◽  
Da-Li Feng ◽  
...  
Keyword(s):  
Mitochondrial Genome ◽  
Rat Model ◽  
Complete Sequence ◽  
Sprague Dawley ◽  
Sprague Dawley Rat

The Effect of Gastric Bypass with a Distal Gastric Pouch on Glucose Tolerance and Diabetes Remission in Type 2 Diabetes Sprague-Dawley Rat Model

2019 ◽  
Vol 29 (6) ◽  
pp. 1889-1900 ◽  
Author(s):  
Ponnie Robertlee Dolo ◽  
Yong Shao ◽  
Chao Li ◽  
Xiaocheng Zhu ◽  
Libin Yao ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Gastric Bypass ◽  
Glucose Tolerance ◽  
Rat Model ◽  
Gastric Pouch ◽  
Diabetes Remission ◽  
Sprague Dawley ◽  
Sprague Dawley Rat
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