Lipase-catalysed production of triacylglycerols enriched in pinolenic acid at the sn-2 position from pine nut oil

2011 ◽  
Vol 92 (4) ◽  
pp. 870-876 ◽  
Author(s):  
Jong-Hun Choi ◽  
Byung Hee Kim ◽  
Seung In Hong ◽  
Chong-Tai Kim ◽  
Chul-Jin Kim ◽  
...  
Keyword(s):  
Pinolenic Acid ◽  
Pine Nut ◽  
Pine Nut Oil

Lipase-Catalyzed Production of Pinolenic Acid Concentrate from Pine Nut Oil Using a Recirculating Packed Bed Reactor

2012 ◽  
Vol 77 (2) ◽  
pp. C267-C271 ◽  
Author(s):  
TingTing Zhao ◽  
Byung Hee Kim ◽  
Seung In Hong ◽  
Sung Won Yoon ◽  
Chong-Tai Kim ◽  
...  
Keyword(s):  
Packed Bed ◽  
Packed Bed Reactor ◽  
Pinolenic Acid ◽  
Pine Nut ◽  
Pine Nut Oil

Selective increase in pinolenic acid (all-cis-5,9,12–18∶3) in Korean pine nut oil by crystallization and its effect on LDL-receptor activity

Lipids ◽  
2004 ◽  
Vol 39 (4) ◽  
pp. 383-387 ◽  
Author(s):  
Jin-Won Lee ◽  
Kwang-Won Lee ◽  
Seog-Won Lee ◽  
In-Hwan Kim ◽  
Chul Rhee
Keyword(s):  
Ldl Receptor ◽  
Receptor Activity ◽  
Korean Pine ◽  
Pinolenic Acid ◽  
Pine Nut ◽  
Pine Nut Oil ◽  
Selective Increase

Preparation of highly purified pinolenic acid from pine nut oil using a combination of enzymatic esterification and urea complexation

2015 ◽  
Vol 170 ◽  
pp. 386-393 ◽  
Author(s):  
Da Som No ◽  
Ting Ting Zhao ◽  
Yangha Kim ◽  
Mi-Ra Yoon ◽  
Jeom-Sig Lee ◽  
...  
Keyword(s):  
Enzymatic Esterification ◽  
Pinolenic Acid ◽  
Urea Complexation ◽  
Pine Nut ◽  
Pine Nut Oil

scholarly journals Activity of dietary fatty acids on FFA1 and FFA4 and characterisation of pinolenic acid as a dual FFA1/FFA4 agonist with potential effect against metabolic diseases

2015 ◽  
Vol 113 (11) ◽  
pp. 1677-1688 ◽  
Author(s):  
Elisabeth Christiansen ◽  
Kenneth R. Watterson ◽  
Claire J. Stocker ◽  
Elena Sokol ◽  
Laura Jenkins ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Free Fatty Acid ◽  
Glucose Tolerance ◽  
Metabolic Diseases ◽  
Pinolenic Acid ◽  
Acid Receptor ◽  
Pine Nut ◽  
Free Fatty Acid Receptor ◽  
Pine Nut Oil

Various foods are associated with effects against metabolic diseases such as insulin resistance and type 2 diabetes; however, their mechanisms of action are mostly unclear. Fatty acids may contribute by acting as precursors of signalling molecules or by direct activity on receptors. The medium- and long-chain NEFA receptor FFA1 (free fatty acid receptor 1, previously known as GPR40) has been linked to enhancement of glucose-stimulated insulin secretion, whereas FFA4 (free fatty acid receptor 4, previously known as GPR120) has been associated with insulin-sensitising and anti-inflammatory effects, and both receptors are reported to protect pancreatic islets and promote secretion of appetite and glucose-regulating hormones. Hypothesising that FFA1 and FFA4 mediate therapeutic effects of dietary components, we screened a broad selection of NEFA on FFA1 and FFA4 and characterised active compounds in concentration–response curves. Of the screened compounds, pinolenic acid, a constituent of pine nut oil, was identified as a relatively potent and efficacious dual FFA1/FFA4 agonist, and its suitability for further studies was confirmed by additional in vitro characterisation. Pine nut oil and free and esterified pure pinolenic acid were tested in an acute glucose tolerance test in mice. Pine nut oil showed a moderately but significantly improved glucose tolerance compared with maize oil. Pure pinolenic acid or ethyl ester gave robust and highly significant improvements of glucose tolerance. In conclusion, the present results indicate that pinolenic acid is a comparatively potent and efficacious dual FFA1/FFA4 agonist that exerts antidiabetic effects in an acute mouse model. The compound thus deserves attention as a potential active dietary ingredient to prevent or counteract metabolic diseases.

scholarly journals Preparation of Pinolenic Acid Concentrates from Pine Nut Oil Fatty Acids by Solvent Fractionation

2018 ◽  
Vol 67 (11) ◽  
pp. 1373-1379 ◽  
Author(s):  
Min-Yu Chung ◽  
In-Hwan Kim ◽  
Byung Hee Kim
Keyword(s):  
Fatty Acids ◽  
Pinolenic Acid ◽  
Solvent Fractionation ◽  
Pine Nut ◽  
Pine Nut Oil

Enrichment of pinolenic acid from pine nut oil via lipase-catalyzed ethanolysis with an immobilizedCandida antarcticalipase

2011 ◽  
Vol 29 (4) ◽  
pp. 155-160 ◽  
Author(s):  
Bo-Mi Lee ◽  
Jong-Hun Choi ◽  
Seung In Hong ◽  
Sung Won Yoon ◽  
Byung Hee Kim ◽  
...  
Keyword(s):  
Pinolenic Acid ◽  
Pine Nut ◽  
Pine Nut Oil

scholarly journals Effects of Delayed-Release Olive Oil and Hydrolyzed Pine Nut Oil on Glucose Tolerance, Incretin Secretion and Appetite in Humans

Nutrients ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 3407
Author(s):  
Karina Sørensen ◽  
Mads Kaspersen ◽  
Jeppe Ekberg ◽  
Annette Bauer-Brandl ◽  
Trond Ulven ◽  
...  
Keyword(s):  
Glucose Tolerance ◽  
Olive Oil ◽  
Repeated Measures ◽  
Synergistic Effects ◽  
Oral Glucose ◽  
Delayed Release ◽  
Pine Nut ◽  
Gastrointestinal Tolerability ◽  
Incretin Secretion ◽  
Pine Nut Oil

Background: To investigate the potential synergistic effects of olive oil releasing 2-oleoylglycerol and hydrolyzed pine nut oil containing 20% pinolenic acid on GLP-1 secretion, glucose tolerance, insulin secretion and appetite in healthy individuals, when delivered to the small intestine as potential agonists of GPR119, FFA1 and FFA4. Methods: Nine overweight/obese individuals completed three 6-h oral glucose tolerance tests (OGTTs) in a crossover design. At -30 min, participants consumed either: no oil, 6 g of hydrolyzed pine nut oil (PNO-FFA), or a combination of 3 g hydrolyzed pine nut oil and 3 g olive oil (PNO-OO) in delayed-release capsules. Repeated measures of glucose, insulin, C-peptide, GLP-1, GIP, ghrelin, subjective appetite and gastrointestinal tolerability were done. Results: PNO-FFA augmented GLP-1 secretion from 0–360 min compared to no oil and PNO-OO (p < 0.01). GIP secretion was increased from 240–360 min after both PNO-FFA and PNO-OO versus no oil (p < 0.01). Both oil treatments suppressed subjective appetite by reducing hunger and prospective food consumption and increasing satiety (p < 0.05). Conclusions: In support of previous findings, 6 g of delayed-release hydrolyzed pine nut oil enhanced postprandial GLP-1 secretion and reduced appetite. However, no synergistic effect of combining hydrolyzed pine nut oil and olive oil on GLP-1 secretion was observed. These results need further evaluation in long-term studies including effects on bodyweight and insulin sensitivity.

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