Determination of uric acid precursors in dried yeast and other forms of single-cell protein

1975 ◽  
Vol 26 (11) ◽  
pp. 1673-1680 ◽  
Author(s):  
William E. Trevelyan
Keyword(s):  
Uric Acid ◽  
Single Cell ◽  
Single Cell Protein ◽  
Cell Protein

A Single Cell Protein as Standard Reference Material for Determination of Amino Acids, Fatty Acids, and Elements in Foods

1991 ◽  
Vol 74 (1) ◽  
pp. 104-106
Author(s):  
Abdul Aziz ◽  
Faisal Abu-Dagga
Keyword(s):  
Amino Acids ◽  
Fatty Acids ◽  
Reference Material ◽  
Single Cell ◽  
Standard Reference Material ◽  
Room Temperature ◽  
Trace Element Composition ◽  
Single Cell Protein ◽  
Cell Protein

Abstract A commercially available single-cell protein (Pruteen) was analyzed for amino acids, fatty acids, and major, minor, and trace-element composition after storage at room temperature and at 4°C over a period of 5 years. The purpose was to assess its suitability as an organic-nutrient standard reference material for food analysis. The material showed longterm stability and is, therefore, recommended for interlaboratory certification studies.

Platelet Aggregation in Rats in Relation to Hyperuricaemia Induced by Dietary Single-Cell Protein and to Protein Deficiency

1978 ◽  
Vol 39 (02) ◽  
pp. 346-359 ◽  
Author(s):  
P D Winocour ◽  
M R Turner ◽  
T G Taylor ◽  
K A Munday
Keyword(s):  
Uric Acid ◽  
Platelet Count ◽  
Platelet Aggregation ◽  
Time Lag ◽  
Blood Platelet ◽  
Single Cell Protein ◽  
Cell Protein ◽  
Low Protein ◽  
Blood Platelet Count ◽  
Rat Platelets

SummaryA major limitation to single-cell protein (SCP) as a human food is its high nucleic acid content, the purine moiety of which is metabolised to uric acid. Rats given a Fusarium mould as a source of SCP in diets containing oxonate, a uricase inhibitor, showed elevated plasma and kidney uric acid concentrations after 21 d, which were related to the level of dietary mould. ADP-induced and thrombin-induced platelet aggregation was greater in the hyperuricaemic rats than in controls and a progressive increase in aggregation with increasing levels of dietary mould was observed. Furthermore a time-lag, exceeding the life-span of rat platelets, was observed between the development of hyperuricaemia and the increase in aggregation. A similar time-lag was observed between the lowering of the hyperuricaemia and the reduction of platelet aggregation when oxonate was removed from the diet.If human platelets react to uric acid in the same manner as rat platelets this might explain the link that has been suggested between hyperuricaemia and ischaemic heart disease. In that event diets high in nucleic acids might be contra-indicated in people at risk from ischaemic heart disease.In rats given a low protein diet (50 g casein/kg) for 21 d ADP-induced and thrombin-induced platelet aggregation and whole blood platelet count were reduced compared with control animals receiving 200 g casein/kg diet but not in rats given 90 or 130 g casein/kg diet. A study of the time course on this effect indicated that the reduction both in aggregation tendency and in whole blood platelet count occurred after 4 d of feeding the low protein diet. These values were further reduced with time.

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