Pomegranate peel attenuates dextran sulfate sodium‐induced lipid peroxidation in rat small intestine by enhancing the glutathione/glutathione disulfide redox potential

2021 ◽  
Author(s):  
Kaïs H Al‐Gubory ◽  
Ismail Laher ◽  
Catherine Garrel
Keyword(s):  
Lipid Peroxidation ◽  
Small Intestine ◽  
Redox Potential ◽  
Dextran Sulfate ◽  
Dextran Sulfate Sodium ◽  
Rat Small Intestine ◽  
Glutathione Disulfide ◽  
Pomegranate Peel

scholarly journals SUPPRESSION EFFECT OF MAHKOTA DEWA (PHALERIA MACROCARPA) LEAF EXTRACT IN CHITOSAN NANOPARTICLES ON THE SMALL INTESTINE OF DEXTRAN SULFATE SODIUM-INDUCED MICE: FOCUS ON MITOSIS AND HYPERPLASIA

2018 ◽  
Vol 11 (6) ◽  
pp. 118
Author(s):  
Kusmardi Kusmardi ◽  
Arif Ramadhan Tamzir ◽  
Santi Widiasari ◽  
Ari Estuningtyas
Keyword(s):  
Small Intestine ◽  
Leaf Extract ◽  
Dextran Sulfate ◽  
Dextran Sulfate Sodium ◽  
Chitosan Nanoparticles ◽  
Negative Control ◽  
Suppression Effect ◽  
Significant Difference ◽  
Phaleria Macrocarpa

Objective: The incidence of small intestine cancer (SIC) is rising despite available preventive measures. Kaempferol and quercetin are a potential chemopreventive agent for SIC, but in vivo findings are inconclusive. We aim to study the effects of kaempferol and quercetin on colitis-associated small intestine carcinogenesis in mice.Methods: Suppression effect was tested using mice divided into 6 groups of treatment, i.e.; normal (N) group, negative control (NC), leaf extract (medium dose [MD]) dose 12.5 and 25 mg/kg body weight (BW), leaf extract chitosan and nanoparticle of mahkota dewa (NPMD) dose 6.25 and 12.5 mg/kg BW. Dextran sulfate sodium induction of 1% w/v was administered through drinking water for 6 weeks of treatment. The suppression effect was observed histopathologically by counting the mitotic cells and hyperplasia cells of the crypt of small intestine with hematoxylin-eosin staining.Results: Mitosis cells mean of NC group was not significant difference either with MD 12.5 (p=0.394) or MD 6.5 (p=0.310). However, mitosis cell mean appears to be lower in the NPMD 12.5 (p=0.09) and NPMD 6.25 (p=0.05) groups than the NC group. There was a significant difference among the mean of hyperplasia NC group and MD and also NPMD group. Significant difference also can be showed between MD 12.5 and MD 25 (p=0.026), and between NPMD 6.25 and NPMD 12.5 (p=0.002), and between MD 12.5 and NPMD 12.5 (p=0.002).Conclusion: Our results demonstrate suppression of hyperplasia small intestine by either nanoparticle or extract of Phaleria macrocarpa extracts. The suppression of mitosis was showed by administration of nanoparticle.

Biochemical and histological changes in the small intestine of mice with dextran sulfate sodium colitis

2011 ◽  
Vol 226 (12) ◽  
pp. 3219-3224 ◽  
Author(s):  
Roger Yazbeck ◽  
Gordon S. Howarth ◽  
Ross N. Butler ◽  
Mark S. Geier ◽  
Catherine A. Abbott
Keyword(s):  
Small Intestine ◽  
Dextran Sulfate ◽  
Dextran Sulfate Sodium ◽  
Histological Changes

Ethanol effects on lipid peroxidation and glutathione-mediated defense in rat small intestine: Role of dietary fats

Alcohol ◽  
1998 ◽  
Vol 15 (1) ◽  
pp. 65-69 ◽  
Author(s):  
Meenu Kaur ◽  
Jyotdeep Kaur ◽  
S. Ojha ◽  
Akhtar Mahmood
Keyword(s):  
Lipid Peroxidation ◽  
Small Intestine ◽  
Dietary Fats ◽  
Rat Small Intestine

scholarly journals HOMEOSTASIS CHANGE IN THE SMALL INTESTINE WITH DISTURBED REGIONAL BLOOD FLOW IN EARLY POSTNATAL ONTOGENESIS

2018 ◽  
Vol 1 (2) ◽  
Author(s):  
Sergey Anatol`evich Markos`yan
Keyword(s):  
Lipid Peroxidation ◽  
Blood Flow ◽  
Small Intestine ◽  
Redox Potential ◽  
Blood Supply ◽  
Regional Blood Flow ◽  
Intestinal Wall ◽  
Early Age ◽  
Ischemic Region ◽  
Oxygen Coefficient

Objective: A study of the ischemic damage course and regeneration in the small intestine with disturbed regional blood flow in early postnatal ontogenesis.Materials and Methods: The experiments were carried out on 30 puppies at the age from 1 to 4 weeks. The state of regional blood flow in the ischemic area of the small intestine was investigated by blood filling of tissues, metabolism - by redox potential, oxygen pressure and diffusion oxygen coefficient, lipid peroxidation activity and catalase activity. Database formation and statistical calculations were performed using the applied programmes "Microsoft Excel", "ANOVA" for "Windows".Results: The performed research showed that in animals of early age pronounced microcirculatory disorders were observed. About this evidenced significant tissue bloodfilling in the ischemic region of the small intestine. Essential disorder of the blood supply in the organ naturally led to a pronounced fall in the redox potential, the oxygen pressure, and the diffusion oxygen coefficient in the tissues.On a level with the disturbances in the electrogenesis and tissue oxygenation, we found a significant diminution in their antioxidant capacity, as evidenced by a pronounced increase in lipid peroxidation and a decrease in catalytic activity. Insufficient oxygen supply of tissues caused the development of irreversible changes in the intestinal wall, the disorder of the organ motility with frequent appearance of small intestinal intussusception.Conclusions: A significant disturbance of the small intestine blood supply at the early age, caused by an operating trauma, leads to a pronounced decrease in electrical activity and oxygenation of the organ tissues, accompanied by marked metabolic disorders.Oxygen starvation of tissues in the ischemic region of the small intestine at the early age contributes to the development of irreversible changes in the intestinal wall, and frequent disruption of the regeneration process in this area. Keywords: small intestine; local ischemia; early age

Postischemic accumulation of the lipid peroxidation product 4-hydroxynonenal in rat small intestine

Life Sciences ◽  
1994 ◽  
Vol 55 (9) ◽  
pp. 693-699 ◽  
Author(s):  
Tilman Grune ◽  
Werner G. Siems ◽  
Jan Kowalewski ◽  
Hermann Esterbauer
Keyword(s):  
Lipid Peroxidation ◽  
Small Intestine ◽  
Lipid Peroxidation Product ◽  
Rat Small Intestine ◽  
Peroxidation Product
Sign in / Sign up

Export Citation Format

Share Document