Molecular action mechanism of anti‐inflammatory hydrolysates obtained from brewers' spent grain

2020 ◽  
Vol 100 (7) ◽  
pp. 2880-2888
Author(s):  
Raúl E Cian ◽  
Cristina Hernández‐Chirlaque ◽  
Reyes Gámez‐Belmonte ◽  
Silvina R Drago ◽  
Fermín Sánchez de Medina ◽  
...  
Keyword(s):  
Action Mechanism ◽  
Molecular Action ◽  
Spent Grain ◽  
Anti Inflammatory

Multi-Phase Solvation Model for Biological Membranes: Molecular Action Mechanism of Amphotericin B

2017 ◽  
Vol 13 (7) ◽  
pp. 3388-3397 ◽  
Author(s):  
J. M. Falcón-González ◽  
G. Jiménez-Domínguez ◽  
I. Ortega-Blake ◽  
M. Carrillo-Tripp
Keyword(s):  
Amphotericin B ◽  
Biological Membranes ◽  
Action Mechanism ◽  
Solvation Model ◽  
Molecular Action ◽  
Multi Phase

scholarly journals Study of the effect of some drugs used in the clinic on the AQP1 activity of the human erythrocyte membrane

2021 ◽  
Vol 18 (2) ◽  
pp. 204-211
Author(s):  
K. V. Basiakova ◽  
E. P. Titovets
Keyword(s):  
Erythrocyte Membrane ◽  
Water Exchange ◽  
Inhibitory Effect ◽  
Wide Distribution ◽  
Stopped Flow ◽  
Human Tissues ◽  
Human Erythrocyte Membrane ◽  
Action Mechanism ◽  
Molecular Action ◽  
Therapeutic Measures

Using the stopped flow method and based on the study of the intensity of light scattering, the effect of pharmacological preparations used in the clinic on the water exchange of human erythrocytes, catalyzed by aquaporin AQP1, was studied. Pharmacological preparations used in therapeutic concentrations have a variable inhibitory effect on water permeability of the erythrocyte membrane. The obtained results broaden our understanding of the molecular action mechanism of the investigated drugs. In view of the wide distribution of AQP1 in various human tissues, these data should be taken into account when carrying out therapeutic measures aimed at normalizing the water exchange of organs and tissues.

In vitro antioxidant and anti-inflammatory effects of brewers' spent grain protein rich isolate and its associated hydrolysates

2013 ◽  
Vol 50 (1) ◽  
pp. 205-212 ◽  
Author(s):  
Aoife L. McCarthy ◽  
Yvonne C. O'Callaghan ◽  
Alan Connolly ◽  
Charles O. Piggott ◽  
Richard J. FitzGerald ◽  
...  
Keyword(s):  
Grain Protein ◽  
Spent Grain ◽  
Anti Inflammatory ◽  
Protein Rich

scholarly journals IRAK1/4-Targeted Anti-Inflammatory Action of Caffeic Acid

2013 ◽  
Vol 2013 ◽  
pp. 1-12 ◽  
Author(s):  
Woo Seok Yang ◽  
Deok Jeong ◽  
Young-Su Yi ◽  
Jae Gwang Park ◽  
Hyohyun Seo ◽  
...  
Keyword(s):  
Caffeic Acid ◽  
Nuclear Translocation ◽  
Biological Activities ◽  
Kinase Assay ◽  
Raw264.7 Cells ◽  
Prostaglandin E ◽  
Mrna Levels ◽  
Action Mechanism ◽  
Anti Inflammatory ◽  
Inflammatory Action

Caffeic acid (CA) is a phenolic compound that is frequently present in fruits, grains, and dietary supplements. Although CA has been reported to display various biological activities such as anti-inflammatory, anti-cancer, anti-viral, and anti-oxidative effects, the action mechanism of CA is not yet fully elucidated. In this study, the anti-inflammatory action mechanism of CA was examined in lipopolysaccharide (LPS) treated macrophages (RAW264.7 cells) and HCl/EtOH-induced gastritis. CA was found to diminish nitric oxide (NO) and prostaglandin E2(PGE2) production in LPS-stimulated RAW264.7 cells. Additionally, mRNA levels of tumor necrosis factor (TNF)-α, cyclooxygenase (COX)-2, and inducible NO synthase (iNOS) were downregulated by CA. CA also strongly suppressed the nuclear translocation of AP-1 family proteins and the related upstream signaling cascade composed of interleukin-1 receptor-associated kinase 1 (IRAK1), IRAK4, TGF-β-activated kinase 1 (TAK1), mitogen-activated protein kinase kinase 4/7 (MKK4/7), and c-Jun N-terminal kinase (JNK). In a direct kinase assay, CA was revealed to directly inhibit IRAK1 and IRAK4. CA also ameliorated HCl/EtOH-induced gastric symptoms via the suppression of JNK, IRAK1, and IRAK4. Therefore, our data strongly suggest that CA acts as an anti-inflammatory drug by directly suppressing IRAK1 and IRAK4.

scholarly journals The Role of Organic Small Molecules in Pain Management

Molecules ◽  
2021 ◽  
Vol 26 (13) ◽  
pp. 4029
Author(s):  
Sebastián A. Cuesta ◽  
Lorena Meneses
Keyword(s):  
Neuropathic Pain ◽  
Pain Management ◽  
Cannabinoid Receptor ◽  
Pain Treatment ◽  
Structural Difference ◽  
Selective Inhibition ◽  
Action Mechanism ◽  
Willow Bark ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

In this review, a timeline starting at the willow bark and ending in the latest discoveries of analgesic and anti-inflammatory drugs will be discussed. Furthermore, the chemical features of the different small organic molecules that have been used in pain management will be studied. Then, the mechanism of different types of pain will be assessed, including neuropathic pain, inflammatory pain, and the relationship found between oxidative stress and pain. This will include obtaining insights into the cyclooxygenase action mechanism of nonsteroidal anti-inflammatory drugs (NSAID) such as ibuprofen and etoricoxib and the structural difference between the two cyclooxygenase isoforms leading to a selective inhibition, the action mechanism of pregabalin and its use in chronic neuropathic pain, new theories and studies on the analgesic action mechanism of paracetamol and how changes in its structure can lead to better characteristics of this drug, and cannabinoid action mechanism in managing pain through a cannabinoid receptor mechanism. Finally, an overview of the different approaches science is taking to develop more efficient molecules for pain treatment will be presented.

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