Advances in surface‐enhanced Raman spectroscopy for cancer diagnosis and staging

2019 ◽  
Vol 51 (1) ◽  
pp. 7-36 ◽  
Author(s):  
Avishek Chakraborty ◽  
Aritri Ghosh ◽  
Ananya Barui
Keyword(s):  
Raman Spectroscopy ◽  
Cancer Diagnosis ◽  
Surface Enhanced Raman Spectroscopy ◽  
Surface Enhanced ◽  
Surface Enhanced Raman

Ultra-sensitive magnetic immunoassay of HE4 based on surface enhanced Raman spectroscopy

2015 ◽  
Vol 7 (16) ◽  
pp. 6489-6495 ◽  
Author(s):  
Ming Ge ◽  
Chao Wei ◽  
Minmin Xu ◽  
Congwei Fang ◽  
Yaxian Yuan ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Raman Spectroscopy ◽  
Tumor Marker ◽  
Cancer Diagnosis ◽  
Surface Enhanced Raman Spectroscopy ◽  
Serological Marker ◽  
Human Epididymis Protein 4 ◽  
Human Epididymis ◽  
Surface Enhanced ◽  
Surface Enhanced Raman

Human epididymis protein 4 (HE4), as a serological marker, has been proposed to be the most promising tumor marker in ovarian cancer diagnosis.

Bacterial detection and differentiation via direct volatile organic compound sensing with surface enhanced Raman spectroscopy

2017 ◽  
Author(s):  
Caitlin S. DeJong ◽  
David I. Wang ◽  
Aleksandr Polyakov ◽  
Anita Rogacs ◽  
Steven J. Simske ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Bacterial Infections ◽  
Direct Detection ◽  
Point Of Care ◽  
Surface Enhanced Raman Spectroscopy ◽  
E Coli ◽  
Recent Emergence ◽  
Surface Enhanced ◽  
Volatile Organic ◽  
Surface Enhanced Raman

Through the direct detection of bacterial volatile organic compounds (VOCs), via surface enhanced Raman spectroscopy (SERS), we report here a reconfigurable assay for the identification and monitoring of bacteria. We demonstrate differentiation between highly clinically relevant organisms: <i>Escherichia coli</i>, <i>Enterobacter cloacae</i>, and <i>Serratia marcescens</i>. This is the first differentiation of bacteria via SERS of bacterial VOC signatures. The assay also detected as few as 10 CFU/ml of <i>E. coli</i> in under 12 hrs, and detected <i>E. coli</i> from whole human blood and human urine in 16 hrs at clinically relevant concentrations of 10<sup>3</sup> CFU/ml and 10<sup>4</sup> CFU/ml, respectively. In addition, the recent emergence of portable Raman spectrometers uniquely allows SERS to bring VOC detection to point-of-care settings for diagnosing bacterial infections.

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