Preparation of monodisperse bimetallic nanorods with gold nanorod core and silver shell and their plasmonic property and SERS efficiency

2014 ◽  
Vol 45 (6) ◽  
pp. 431-437 ◽  
Author(s):  
Xu Dong ◽  
Jianfeng Zhou ◽  
Xiaoyun Liu ◽  
Danli Lin ◽  
Liusheng Zha
Keyword(s):  
Gold Nanorod ◽  
Plasmonic Property ◽  
Bimetallic Nanorods ◽  
Silver Shell

Interference of Steroidogenesis by Gold Nanorod Core/Silver Shell Nanostructures: Implications for Reproductive Toxicity of Silver Nanomaterials

Small ◽  
2016 ◽  
Vol 13 (10) ◽  
pp. 1602855 ◽  
Author(s):  
Xiumei Jiang ◽  
Liming Wang ◽  
Yinglu Ji ◽  
Jinglong Tang ◽  
Xin Tian ◽  
...  
Keyword(s):  
Reproductive Toxicity ◽  
Gold Nanorod ◽  
Shell Nanostructures ◽  
Silver Nanomaterials ◽  
Silver Shell

Single-Dosed Genotoxicity Study of Gold Nanorod Core/Silver Shell Nanostructures by Pig-a, Micronucleus, and Comet Assays

2018 ◽  
Vol 14 (11) ◽  
pp. 1953-1964 ◽  
Author(s):  
Dan Wang ◽  
Mo Dan ◽  
Yinglu Ji ◽  
Xiaochun Wu ◽  
Liming Xu ◽  
...  
Keyword(s):  
Gold Nanorod ◽  
Shell Nanostructures ◽  
Silver Shell

scholarly journals In Vivo Metabolic Response upon Exposure to Gold Nanorod Core/Silver Shell Nanostructures: Modulation of Inflammation and Upregulation of Dopamine

2020 ◽  
Vol 21 (2) ◽  
pp. 384 ◽  
Author(s):  
Haiyun Li ◽  
Tao Wen ◽  
Tao Wang ◽  
Yinglu Ji ◽  
Yaoyi Shen ◽  
...  
Keyword(s):  
Rational Design ◽  
Molecular Mechanisms ◽  
Metabolic Response ◽  
Dopamine Metabolism ◽  
Gold Nanorod ◽  
Ag Nps ◽  
Shell Nanostructures ◽  
Antioxidant Defense Systems ◽  
Silver Shell

With the increasing applications of silver nanoparticles (Ag NPs), the concerns of widespread human exposure as well as subsequent health risks have been continuously growing. The acute and chronic toxicities of Ag NPs in cellular tests and animal tests have been widely investigated. Accumulating evidence shows that Ag NPs can induce inflammation, yet the overall mechanism is incomplete. Herein, using gold nanorod core/silver shell nanostructures (Au@Ag NRs) as a model system, we studied the influence on mice liver and lungs from the viewpoint of metabolism. In agreement with previous studies, Au@Ag NRs’ intravenous exposure caused inflammatory reaction, accompanying with metabolic alterations, including energy metabolism, membrane/choline metabolism, redox metabolism, and purine metabolism, the disturbances of which contribute to inflammation. At the same time, dopamine metabolism in liver was also changed. This is the first time to observe the production of dopamine in non-neural tissue after treatment with Ag NPs. As the upregulation of dopamine resists inflammation, it indicates the activation of antioxidant defense systems against oxidative stress induced by Au@Ag NRs. In the end, our findings deepened the understanding of molecular mechanisms of Ag NPs-induced inflammation and provide assistance in the rational design of their biomedical applications.

scholarly journals Roles of ROS and Cell Cycle Arrest in the Genotoxicity Induced by Gold Nanorod Core/silver Shell Nanostructure 

2020 ◽  
Author(s):  
Dan Wang ◽  
Mo Dan ◽  
Yinglu Ji ◽  
Xiaochun Wu ◽  
Xue Wang ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Dna Cleavage ◽  
Micronucleus Test ◽  
Gold Nanorod ◽  
Chromosome Damage ◽  
Ion Release ◽  
Cycle Arrest ◽  
Heparg Cells ◽  
Silver Shell

Abstract To understand the genotoxicity induced in the liver by silver nanoparticles (AgNPs) and silver ions, an engineered gold nanorod core/silver shell nanostructure (Au@Ag NR) and humanized hepatocyte HepaRG cells were used in this study. The involvement of oxidative stress and cell cycle arrest in the DNA and chromosome damage induced by 0.4 - 20 µg.mL-1 Au@Ag NR were investigated by comet assay, γ-H2AX assay, and micronucleus test. Further, the distribution of Au@Ag NR was analyzed. Our results demonstrated that both Ag+ and Au@Ag NR led to DNA cleavage and chromosome damage (clastogenicity) in HepaRG cells, and that the Au@Ag NR retained in the nucleus may further release Ag+, aggravating the damages, which are mainly caused by cell cycle arrest and ROS formation. The results reveal the correlation between the intracellular accumulation, Ag+ ion release as well as the potential genotoxicity of AgNPs.

Initiation of protective autophagy in hepatocytes by gold nanorod core/silver shell nanostructures

Nanoscale ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 6429-6437 ◽  
Author(s):  
Haiyun Li ◽  
Jiaqi Chen ◽  
Huizhen Fan ◽  
Rui Cai ◽  
Xinshuang Gao ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Human Hepatocytes ◽  
Gold Nanorod ◽  
Shell Nanostructures ◽  
Lethal Doses ◽  
Silver Shell

At sub-lethal doses, Au@Ag NRs induce oxidative stress that activates the protective autophagy of human hepatocytes.

scholarly journals Roles of ROS and cell cycle arrest in the genotoxicity induced by gold nanorod core/silver shell nanostructure

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
Dan Wang ◽  
Mo Dan ◽  
Yinglu Ji ◽  
Xiaochun Wu ◽  
Xue Wang ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Dna Cleavage ◽  
Micronucleus Test ◽  
Gold Nanorod ◽  
Chromosome Damage ◽  
Ion Release ◽  
Cycle Arrest ◽  
Heparg Cells ◽  
Silver Shell

AbstractTo understand the genotoxicity induced in the liver by silver nanoparticles (AgNPs) and silver ions, an engineered gold nanorod core/silver shell nanostructure (Au@Ag NR) and humanized hepatocyte HepaRG cells were used in this study. The involvement of oxidative stress and cell cycle arrest in the DNA and chromosome damage induced by 0.4–20 µg mL−1 Au@Ag NR were investigated by comet assay, γ-H2AX assay and micronucleus test. Further, the distribution of Au@Ag NR was analyzed. Our results demonstrated that both Ag+ and Au@Ag NR led to DNA cleavage and chromosome damage (clastogenicity) in HepaRG cells and that the Au@Ag NR retained in the nucleus may further release Ag+, aggravating the damages, which are mainly caused by cell cycle arrest and ROS formation. The results reveal the correlation between the intracellular accumulation, Ag+ ion release and the potential genotoxicity of AgNPs.

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