Anticonvulsant Activity of Some Uracils and Related Compounds*

Duane G. Wenzel

doi:10.1002/jps.3030440911

Anticonvulsant Activity of Some Uracils and Related Compounds*

Journal of the American Pharmaceutical Association (Scientific ed ) ◽

10.1002/jps.3030440911 ◽

1955 ◽

Vol 44 (9) ◽

pp. 550-553 ◽

Cited By ~ 18

Author(s):

Duane G. Wenzel

Keyword(s):

Anticonvulsant Activity ◽

Related Compounds

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ChemInform Abstract: Synthesis and Anticonvulsant Activity of Some Benzopyranone Imino Derivatives (I) of GABA and Related Compounds.

ChemInform ◽

10.1002/chin.199220191 ◽

2010 ◽

Vol 23 (20) ◽

pp. no-no

Author(s):

A. ARNOLDI ◽

L. MERLINI ◽

M. L. QUADRI ◽

A. BONSIGNORI ◽

P. MELLONI ◽

...

Keyword(s):

Anticonvulsant Activity ◽

Related Compounds

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Synthesis of several 4-hydroxy-3,5-dimethoxybenzamides, their O-substituted derivatives and some related compounds as potential neurotropic agents

Collection of Czechoslovak Chemical Communications ◽

10.1135/cccc19850510 ◽

1985 ◽

Vol 50 (2) ◽

pp. 510-518 ◽

Cited By ~ 1

Author(s):

Vladimír Valenta ◽

Miroslav Protiva

Keyword(s):

Blood Pressure ◽

Catalytic Hydrogenation ◽

Anticonvulsant Activity ◽

Sodium Hydride ◽

Antiemetic Agent ◽

Related Compounds ◽

Neurotropic Agents ◽

Amino Ether

Reactions of 4-benzyloxy-3,5-dimethoxybenzoyl chloride with pyrrolidine, piperidine, morpholine and 1-methylpiperazine gave the amides IIIa-IIId which were debenzylated by catalytic hydrogenation on palladium. The 4-hydroxy-3,5-dimethoxybenzamides IVa-IVc were then treated with sodium hydride and 2-dimethylaminoethyl chloride to give the O-(2-dimethylaminoethyl)amides Va-Vc. The 3,4,5-trimethoxybenzamide IX was prepared as a homologue of the antiemetic agent "trimethobenzamide" (II) and reduced to the benzylaniline derivative X. The substituted nicotinamide XI was obtained from nicotinoyl chloride and 4-(2-diethylaminoethoxy)aniline. Out of the compounds prepared the amides IIId and Vc had some anticonvulsant activity, the piperazide IVd revealed a significant α-adrenolytic effect and the amino ether X reduced the blood pressure of normotensive rats.

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