ChemInform Abstract: Synthesis and Anticonvulsant Activity of Some Benzopyranone Imino Derivatives (I) of GABA and Related Compounds.

ChemInform ◽  
2010 ◽  
Vol 23 (20) ◽  
pp. no-no
Author(s):  
A. ARNOLDI ◽  
L. MERLINI ◽  
M. L. QUADRI ◽  
A. BONSIGNORI ◽  
P. MELLONI ◽  
...  
Keyword(s):  
Anticonvulsant Activity ◽  
Related Compounds

Synthesis of several 4-hydroxy-3,5-dimethoxybenzamides, their O-substituted derivatives and some related compounds as potential neurotropic agents

1985 ◽  
Vol 50 (2) ◽  
pp. 510-518 ◽  
Author(s):  
Vladimír Valenta ◽  
Miroslav Protiva
Keyword(s):  
Blood Pressure ◽  
Catalytic Hydrogenation ◽  
Anticonvulsant Activity ◽  
Sodium Hydride ◽  
Antiemetic Agent ◽  
Related Compounds ◽  
Neurotropic Agents ◽  
Amino Ether

Reactions of 4-benzyloxy-3,5-dimethoxybenzoyl chloride with pyrrolidine, piperidine, morpholine and 1-methylpiperazine gave the amides IIIa-IIId which were debenzylated by catalytic hydrogenation on palladium. The 4-hydroxy-3,5-dimethoxybenzamides IVa-IVc were then treated with sodium hydride and 2-dimethylaminoethyl chloride to give the O-(2-dimethylaminoethyl)amides Va-Vc. The 3,4,5-trimethoxybenzamide IX was prepared as a homologue of the antiemetic agent "trimethobenzamide" (II) and reduced to the benzylaniline derivative X. The substituted nicotinamide XI was obtained from nicotinoyl chloride and 4-(2-diethylaminoethoxy)aniline. Out of the compounds prepared the amides IIId and Vc had some anticonvulsant activity, the piperazide IVd revealed a significant α-adrenolytic effect and the amino ether X reduced the blood pressure of normotensive rats.

Zebrafish models for hallucinogenic-related compounds

2013 ◽  
Author(s):  
A. V. Kalueff ◽  
A. M. Stewart ◽  
V. Gjeloshi ◽  
D. Kondaveeti ◽  
N. Neelkantan ◽  
...  
Keyword(s):  
Related Compounds

Taxonomic distribution of thymoquinone and related compounds in selected plant species

Planta Medica ◽  
2009 ◽  
Vol 75 (09) ◽  
Author(s):  
J Táborský ◽  
M Kunt ◽  
P Kloucek ◽  
L Kokoska
Keyword(s):  
Plant Species ◽  
Taxonomic Distribution ◽  
Related Compounds
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