Relationship of Chemical Structure to Corneal Penetration and Influence of Low-Viscosity Solution on Ocular Bioavailability

1984 ◽  
Vol 73 (8) ◽  
pp. 1021-1027 ◽  
Author(s):  
George M. Grass ◽  
Joseph R. Robinsonx
Keyword(s):  
Viscosity Solution ◽  
Chemical Structure ◽  
Low Viscosity ◽  
Ocular Bioavailability ◽  
Relationship Of ◽  
Corneal Penetration

The relationship of chemical structure of urea derivatives to antispasmodic activity

1979 ◽  
Vol 13 (5) ◽  
pp. 497-499
Author(s):  
A. G. Pechenkin ◽  
L. G. Tugnibidina ◽  
V. K. Gorshkova ◽  
L. A. Tikhonova
Keyword(s):  
Chemical Structure ◽  
Antispasmodic Activity ◽  
Urea Derivatives ◽  
Relationship Of ◽  
The Relationship

Site of Action and Quantitative Structure-Activity Relationship of a Series of Herbicidal N-Aryl-Substituted 3,4-Dimethyl-2-hydroxy-5-oxo-2,5-dihydro-pyrrolones

1979 ◽  
Vol 34 (11) ◽  
pp. 1028-1031 ◽  
Author(s):  
G. P. Brugnoni ◽  
P. Moser ◽  
A. Trebst
Keyword(s):  
Chemical Structure ◽  
Electron Flow ◽  
Quantitative Structure Activity Relationship ◽  
Herbicidal Activity ◽  
Quantitative Structure ◽  
Photosynthetic Electron Flow ◽  
Acceptor Side ◽  
Structure Activity ◽  
Site Of Action ◽  
Relationship Of

Abstract Substituted phenyl-hydroxy pyrrolone derivatives are potential herbicides and are found to be effective inhibitors of photosynthetic electron flow in chloroplasts. Their site of inhibition is localized at the acceptor side of photosystem II similar to DCMU. They have no effect on photophosphoryla­tion. The correlation of photosynthetic acitivity to chemical structure is studied by comparing 36 derivatives. A clear dependence of inhibitory activity on lipophilicity is found. The dependence of herbicidal activity on chemical structure is more complex.

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