Oxidative Reactions of Hydroxylated Chlorpromazine Metabolites

1977 ◽  
Vol 66 (3) ◽  
pp. 357-361 ◽  
Author(s):  
Richard L. McCreery
Author(s):  
Luis A. Segura-Quezada ◽  
Karina R. Torres-Carbajal ◽  
Yuvraj Satkar ◽  
Kevin A. Juárez Ornelas ◽  
Narendra Mali ◽  
...  

: Iodine(III)-based reagents has been broadly used in oxidative reactions for the structural functionalization with several functional groups. Among the more relevant and useful synthetic transformations using these hypervalent γ 3 -reagents, it can be found the fluorination, chlorination, bromination as well as the iodination protocols. Herein, we present some of the most representatives oxidative halogenation procedures of arenes, olefins and alkynes dating from the oldest to the more recent advances in the area, highlighting the discovery and application of new iodine(III)-based halogenating species.


ChemInform ◽  
2013 ◽  
Vol 44 (39) ◽  
pp. no-no
Author(s):  
Erlei Zhang ◽  
Haiwen Tian ◽  
Sendong Xu ◽  
Xiaochun Yu ◽  
Qing Xu

1925 ◽  
Vol 9 (2) ◽  
pp. 269-284 ◽  
Author(s):  
Otto Glaser

1. For the heart rate in Pterotrachea coronata, intermediate temperatures disclose a thermal increment of 11,200 ±. This value is identical with the one reported by Crozier and Stier for the lamelli-branch, Anodonta. In the pteropod, Tiedemannia neapolitana the same temperatures typically reveal in the heart rate a µ value of 16,200 ± This agrees quantitatively with 16,300 found by Crozier and Stier for the heart of the slug, Limax maximus. 2. At high temperatures the average value of µ for Pterotrachea is 7,300: for Tiedemannia, 7,400. The corresponding averages at the lower limits are 22,000 and 23,000. 3. The great variability found near the edges of the temperature field are explicable in two ways. During intermissions characteristic of high temperatures and occurring also at low, we can assume a restorative process; while at both the upper and lower limits we may, in addition, find that reactions assume control which under ordinary circumstances never do so. Special evidence indicates that the highest temperatures employed, 27°C., and the lowest, 4°C., caused no irreversible changes in mechanism. 4. The theoretical analysis of the experimental facts makes use of Meyerhof's conception of carbohydrate metabolism and projects the cyclical nature of rhythm into the substrate of control. Assuming as a source of energy an original supply of material O, the value of 22,000 ± is assigned provisionally to a mobilization hydrolysis while 11,200 ± and 16,000 ± are attached to oxidative reactions influenced respectively by OH' and possibly Fe, or some other catalyst. The lowest value, 7,300 ± is assumed to indicate a synthetic process (lactic acid → glycogen?), possibly limited by CO2 excretion. In the present state of our knowledge, this distribution and interpretation seems to account reasonably for the experimental facts, but until we know more about the neurogenic controls, is entitled to rank only as an hypothesis.


2016 ◽  
Vol 313 ◽  
pp. 131-137 ◽  
Author(s):  
Fabrizio Palumbo ◽  
Guillermo Garcia-Lainez ◽  
Daniel Limones-Herrero ◽  
M. Dolores Coloma ◽  
Javier Escobar ◽  
...  

2017 ◽  
Vol 94 (2) ◽  
pp. e21373 ◽  
Author(s):  
Pooja Makwana ◽  
Appukuttan Nair R. Pradeep ◽  
Shambhavi P. Hungund ◽  
Kangayam M. Ponnuvel ◽  
Kanika Trivedy

Author(s):  
Shambhu D. Varma ◽  
Richard D. Richards

Pharmacia ◽  
2021 ◽  
Vol 68 (2) ◽  
pp. 479-484
Author(s):  
Marwan Merkhan ◽  
Jehan Mohammad ◽  
Zainab Fathi ◽  
Zaid Younis ◽  
Samir Mahmood ◽  
...  

The aetiology of ischemic heart diseases is mainly based on atherosclerosis of coronary artery. Inflammation and oxidative reactions are initiating and aggravating the illness resulting in pathological remodelling of vasculaturze at site of injury. Endothelium lining of blood vessels participated in the reaction biochemically through releasing some proteins into circulatory system which further complicate the condition. The aim of this study was to determine early diagnosed hyperlipidaemia-associated changes of the plasma level of some of these endothelial biomolecules. Compared to healthy control, hyperlipidaemic patients have significantly increased arginase, metalloendopeptidase, peroxidase, myeloperoxidase, and peroxynitrite with concomitant reduction in arylesterase and nitric oxide. The present study concluded that hyperlipidaemia play a great role in modulation of certain plasma protein markers which might be directly related to patient pathological condition or could be used as a tool for diagnosis or patient follow up indicating the stage of vasculature remodelling, healing, inflammation or resolution.


2001 ◽  
Author(s):  
Jonathan S. Dordick ◽  
Douglas Clark ◽  
Brian H Davison ◽  
Alexander Klibanov
Keyword(s):  

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