Fluorinated Quinazolones III: Synthesis and CNS Depressant Activity of Fluorinated Quinazolone Derivatives

1975 ◽  
Vol 64 (8) ◽  
pp. 1428-1430 ◽  
Author(s):  
Krishna C. Joshi ◽  
Virendra K. Singh ◽  
Daulat S. Mehta ◽  
Ramesh C. Sharma ◽  
Lalit Gupta
Keyword(s):  
Cns Depressant ◽  
Cns Depressant Activity

SCREENING OF ANTI-ANXIETY ACTIVITY OF UNRIPE FRUITS OF MUSA PARADISIACA LINN.

INDIAN DRUGS ◽  
2012 ◽  
Vol 49 (09) ◽  
pp. 33-35
Author(s):  
C. S Hallikeri ◽  
◽  
S. D Joshi ◽  
P Patil ◽  
V. H Kulkarni ◽  
...  
Keyword(s):  
Amino Acids ◽  
Operant Behavior ◽  
Albino Rats ◽  
Alcoholic Extract ◽  
Standard Drug ◽  
Musa Paradisiaca ◽  
Cns Depressant ◽  
Phytochemical Investigation ◽  
Cns Depressant Activity ◽  
Unripe Fruits

The alcoholic extract of unripe fruits of Musa paradisiaca Linn. (Musaceae) was evaluated for antianxiety activity by using operant behavior (behavioral disinhibition) model of anxiety in albino rats. Phytochemical investigation of alcoholic extract revealed the presence of flavonoids, amino acids,vitamins and carbohydrates. Alcoholic extract showed significant anti-punishment and anti-frustration activities at dose level of 500 mg/kg/day for 5 days which is comparable to standard drug, diazepam 5mg/kg. The presence of amino acid and flavonoids in alcoholic extract could be attributed for the antianxiety and other CNS depressant activity.

scholarly journals Pharmacological Screening for CNS Depression, Analgesic and Anti-inflammatory Potentials of Sonneratia caseolaris (Linn.) Barks in Different Solvent Fraction

2019 ◽  
pp. 1-11
Author(s):  
Mst. Shirajum Munira ◽  
Syeda Naureen Ahmed ◽  
Md. Siddiqul Islam ◽  
Md. Shariful Islam ◽  
Mst. Luthfun Nesa ◽  
...  
Keyword(s):  
Late Phase ◽  
Dependent Manner ◽  
Paw Edema ◽  
Superior Result ◽  
Sonneratia Caseolaris ◽  
Cns Depressant ◽  
Anti Inflammatory ◽  
Pharmacological Screening ◽  
Cns Depressant Activity

Aims: Bark of different fractions of Sonneratia caseolaris (Linn.) (Sonneratiaceae) were screened for its analgesic, anti-inflammatory and CNS activities. Study Design: For the purpose of these experiments the extracts were subjected to an in-vivo study. Place and Duration of Study: The study was carried out in August 2014 in the Department of Pharmacy, Southeast University, Dhaka, Bangladesh. Methodology: Ethanolic (ETF), ethyl acetate (EAF), chloroform(CLF) and pet ether (PTF) fractions of bark of  S. caseolaris were used to evaluate the analgesic activity using Acetic acid induced writhing and Formalin test. The same fractions were evaluated for anti-inflammatory activity using Carrageenan induced hind paw edema model. The CNS depressant activity was evaluated by Hole cross method. Two doses of 150 mg/kg and 300 mg/kg were used. Results: The different fractions produced significant (p<0.05) writhing inhibition at both doses and reduced the number of linking induced by formalin. Among these fractions the most potent activity was found in ETF about 79.40% (300 mg/kg) that was almost similar to standard Diclofenac-Na 82.78% (10 mg/kg), then EAF 74.59% followed by CLF 59.03% and PTF 52.45% at dose 300 mg/kg). In formalin-induced paw licking model, all fractions of S. caseolaris showed superior result in the late phase compare to the early phase .The same fractions of extracts caused significant (p<0.05) inhibition of carrageenan induced paw edema in a dose dependent manner. A statistically significant (p<0.05) locomotor activity was also observed. Conclusion: Our result revealed that all the extractives of S. caseolaris have noticeable analgesic, anti-inflammatory and CNS depressant activities.

scholarly journals Pharmacological investigations of Litsea lancifolia (Roxb.) Hook. F.

2020 ◽  
Vol 49 (1) ◽  
pp. 179-183
Author(s):  
Israt Jahan Bulbul ◽  
Mohammad Rashedul Haque ◽  
Mohammad Abdur Rashid
Keyword(s):  
Ethyl Acetate ◽  
Methanolic Extract ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Total Phenolic ◽  
Bioactive Constituents ◽  
Cns Depressant ◽  
Acid Potential ◽  
Cns Depressant Activity ◽  
Soluble Fractions

The petroleum ether, chloroform and ethyl acetate soluble fractions of methanolic extract of Litsea lancifolia Roxb. leaves were subjected to different pharmacological screenings to explore its potential as anti-oxidant, antimicrobial, peripheral analgesic, hypoglycemic and CNS depressing agent. The ethyl acetate soluble fraction showed highest total phenolic content and free radical scavenging activity compared to the standard, acetyl salicylic acid. Potential antimicrobial activity was shown against P. aeruginosa (23.50 mm), E. coli (22.33 mm), B. cereus (18 mm) and S. paratyphi (18 mm). The crude extract demonstrated significant peripheral analgesic (p < 0.01) activity with 69.45 and 77.96% inhibition of acetic acid-induced writhing at 100 and 200 mg/kg b.w., respectively. The crude methanolic extract also showed significant hypoglycemic activity (p < 0.01) at a dose of 500 mg/kg/day on the 7th day of treatment. All the organic soluble fractions exhibited noteworthy (p < 0.001) CNS depressant activity. Taken together, the plant can be considered as a good material for further chemical investigation to isolate the bioactive constituents.

scholarly journals Pharmacological evaluation for Anti-Anxiety and CNS depressant activity of hydro-alcoholic leaves extract of Pongamia pinnata

2021 ◽  
Vol 11 (4-S) ◽  
pp. 22-25
Author(s):  
Jagannath Panda ◽  
Biswajit Samantaray ◽  
Gurudutta Pattnaik
Keyword(s):  
Amino Acids ◽  
Body Weight ◽  
Leaf Extract ◽  
Pongamia Pinnata ◽  
Control Group ◽  
Alcoholic Extract ◽  
Standard Methods ◽  
Cns Depressant ◽  
Depressant Action ◽  
Cns Depressant Activity

The aim of this study was to assess the anti-anxiety and CNS depressant properties of hydro-alcoholic extract of Pongamia pinnata leaves (HALEPP). Standard methods were used to screen the HALEPP's phytochemicals, which showed that the extract contains Flavones, alkaloids, glycosides, proteins and amino acids, gum and mucilage as well as flavonoids, saponins, and steroid hormones. Even at the dose level of 1000 mg/kg body weight, the HALEPP showed no signs of toxicity or mortality in the acute toxicity report. The anti-anxiety behaviour of was studied using light and dark model methods in rats. The CNS depressant action was studied using the extract and actophotometer (Rolex) in rats. The research group (HALEPP 200 gm/kg treated) animals displayed strong anti-anxiety and CNS depressant behaviour similar to the control group (diazepam treated) animals in the current study. The study's findings suggest that the hydro-alcoholic Pongamia pinnata leaf extract has strong anti-anxiety and CNS depressant properties. Keywords: Pongamia pinnata, Anti-Anxiety & CNS depressant

Synthesis, anticonvulsant and CNS depressant activity of some new bioactive 1-(4-substituted-phenyl)-3-(4-oxo-2-phenyl/ethyl-4H-quinazolin-3-yl)-urea

2009 ◽  
Vol 44 (11) ◽  
pp. 4335-4343 ◽  
Author(s):  
Sushil K. Kashaw ◽  
Varsha Kashaw ◽  
Pradeep Mishra ◽  
N.K. Jain ◽  
J.P. Stables
Keyword(s):  
Cns Depressant ◽  
Cns Depressant Activity

ChemInform Abstract: PSYCHOACTIVE AGENTS. PART V. SYNTHESIS AND CNS DEPRESSANT ACTIVITY OF SOME PYRIDYL AND PIPERIDYL ETHERS

1978 ◽  
Vol 9 (23) ◽  
Author(s):  
V. P. ARYA ◽  
J. DAVID ◽  
R. S. GREWAL ◽  
S. B. MARATHE ◽  
S. D. PATIL ◽  
...  
Keyword(s):  
Cns Depressant ◽  
Cns Depressant Activity
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