New Compounds: Amides Derived from [(10,11-Dihydro-5H-dibenzo[a, d]cycloheptens-5-yl)thio]acetic Acid

1972 ◽  
Vol 61 (6) ◽  
pp. 978-980 ◽  
Author(s):  
R.V. Saenz ◽  
J.W. Sowell
Keyword(s):  
Acetic Acid ◽  
New Compounds

scholarly journals Synthesis of Some Novel Fused Imidazo [2, 1-b] [1, 3] Thiazole and Imidazo [2, 1-b] Thiazolo [5, 4-d] Isoxazole Derivatives

2012 ◽  
Vol 9 (3) ◽  
pp. 1518-1525 ◽  
Author(s):  
Hamid Reza Jaberi ◽  
Hadi Noorizadeh
Keyword(s):  
Acetic Acid ◽  
Sodium Acetate ◽  
Carbon Disulphide ◽  
Thiazole Derivatives ◽  
H Nmr ◽  
Nmr Data ◽  
Elemental Analyses ◽  
New Compounds ◽  
Isoxazole Derivatives ◽  
C Nmr

In this work we describe the synthesis of some novel fused imidazo [2, 1-b] [1, 3] thiazole derivatives. The reaction of 1, 2-diaminoethane 1 with carbon disulphide in H2O/ETOH as solvent furnishes 4, 5-dihydro-1H-imidazol-2-thiol 2 under reflux condition. the reaction of 4,5-dihydro-1H-imidazol-2-thiol on treatment with ethylchloro acetate and aromatic aldehyde in presence of anhydrous sodium acetate and acetic acid as solvent to give (Z)-2-(arylidene)-5,6-dihydroimidazo [2,1-b] [1,3] thiazol-3(2H)-one 3a-j. Compounds 3a-j was condensed with hydroxylamine to give 3-(aryl)-2, 3, 6, 7-tetrahydroimidazo [2, 1-b] [1,3] thiazolo [5, 4-d] isoxazole 4a-j. The structures of the new compounds were established by elemental analyses, IR,1H NMR and13C NMR data.

scholarly journals New Synthetic Routes for 1-Benzyl-1,4,7,10-tetraazacyclododecane and 1,4,7,10-Tetraazacyclododecane-1-acetic Acid Ethyl Ester, Important Starting Materials for Metal-coded DOTA-Based Affinity Tags

2007 ◽  
Vol 62 (3) ◽  
pp. 397-406 ◽  
Author(s):  
Stephan W. Kohl ◽  
Katharina Kuse ◽  
Markus Hummert ◽  
Herbert Schumann ◽  
Clemens Mügge ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Ethyl Ester ◽  
Nmr Spectra ◽  
Acid Ethyl Ester ◽  
Affinity Tags ◽  
X Ray ◽  
H Nmr ◽  
Synthetic Routes ◽  
New Compounds ◽  
C Nmr

Two improved routes to synthesize 1-benzyl-1,4,7,10-tetraazacyclododecane (6) and 1,4,7,10- tetraazacyclododecane-1-acetic acid ethyl ester (11) are described as well as the synthesis of 1-{2-[4-(maleimido-N-propylacetamidobutyl)amino]-2-oxoethyl}-1,4,7,10-tetraazacyclododecane- 4,7,10-triacetic acid (17) and its Y, Ho, Tm, and Lu complexes. The 1H and 13C NMR spectra of the new compounds as well as the single crystal X-ray structure analyses of the intermediates 4-benzyl-1,7-bis(p-toluenesulfonyl)diethylenetriamine (3) and 1,4,7-tris(p-toluenesulfonyl)diethylenetriamine (7) are reported and discussed. The rare earth complexes of 17 have been characterized by 1H NMR spectroscopy and MALDI-TOF mass spectrometry.

scholarly journals Synthesis, Characterization and Thermal Analysis of New Cu(II) Complexes with Hydrazide Ligands

2010 ◽  
Vol 7 (s1) ◽  
pp. S278-S282 ◽  
Author(s):  
Saber Rajaei ◽  
Shahriare Ghammamy ◽  
Kheyrollah Mehrani ◽  
Hajar Sahebalzamani
Keyword(s):  
Thermal Stability ◽  
Thermal Analysis ◽  
Acetic Acid ◽  
Ir Spectroscopy ◽  
Coordination Mode ◽  
Azomethine Nitrogen ◽  
Excellent Thermal Stability ◽  
Spectral Techniques ◽  
Ft Ir ◽  
New Compounds

A number of new complexes have been synthesized by reaction of novel ligands acetic acid(4-methyl-benzylidene)hydrazide (L1) and acetic acid(naphthalen-1-ylmethylene)hydrazide (L2) with copper(II) nitrate. These new compounds were characterized by elemental analysis, TG, DTA, IR spectroscopy, UV spectral techniques. The changes observed between the FT-IR and UV-Vis spectra of the ligands and of the complexes allowed us to establish the coordination mode of the metal in complexes. The results suggest that the Schiff bases L1and L2coordinate as univalent anions with their bidentate N,O donors derived from the carbonyl and azomethine nitrogen. Also the probing of thermal analysis complexes can detect which complex has excellent thermal stability.

Synthesis and Antimicrobial Activity of Novel Oxothiazolidine Derivatives

2020 ◽  
Vol 5 (2) ◽  
pp. 91-96
Author(s):  
Balasaheb P. Pagar
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Antimicrobial Activity ◽  
Acetic Acid ◽  
Functional Group ◽  
Acid Hydrazide ◽  
Acid Ethyl Ester ◽  
Diffusion Method ◽  
New Compounds ◽  
Agar Well Diffusion Method

In this article, acid hydrazide 2, a functional group, was synthesized by the reaction of (4-chloro-12- methyl-16,17-dihydro-15-thia-6,11-diaza-cyclopenta[a]phenanthren-7-ylsulfanyl)acetic acid ethyl ester (1) with hydrazine yield (4-chloro-12-methyl-16,17-dihydro-15-thia-6,11-diazacyclopenta[a]- phenanthren-7-ylsulfanyl)acetic acid hydrazide (2) is discussed. The reactive acid hydrazide compound 2 was utilized for the synthesis of amides 3, Schiff’s bases 4 and thiazolidine 5 derivatives. The structures of target compounds were confirmed by elemental analysis and spectral data. The antimicrobial activity of new compounds were studied against Streptococcus sp., Bacillus megaterium, Staphylococcus aureus, Escherichia coli, Bacillus cereus, Bacillus subtilis, Proteus valgaris and Pseudomonas aeroginosa by the agar well diffusion method. Compounds 4b, 5a, 5b and 5c showed good antimicrobial activity

New Compounds. Di-(p-chlorophenyl)-acetic Acid

1945 ◽  
Vol 67 (1) ◽  
pp. 156-156 ◽  
Author(s):  
Oliver Grummitt ◽  
Allen Buck ◽  
James Stearns
Keyword(s):  
Acetic Acid ◽  
New Compounds

scholarly journals Synthesis and Characterization of Some New Benzimidazole Derivatives

2016 ◽  
Vol 13 (1) ◽  
pp. 82-88
Author(s):  
Baghdad Science Journal
Keyword(s):  
Acetic Acid ◽  
Mannich Base ◽  
Condensation Reaction ◽  
Aromatic Aldehydes ◽  
Secondary Amines ◽  
Synthesis And Characterization ◽  
Benzimidazole Derivatives ◽  
Schiff Base Derivatives ◽  
New Compounds

In this paper the new starting material 2-(5-chloro-1H-benzo[d]imidazole-2-yl) aniline (1) was synthesized by the condensation reaction of 4-chloro-o-phenylenediamine and anthranilic acid .The new Mannich base derivatives were synthesized using formaldehyde and different secondary amines to synthesize a new set of benzimidazole derivatives(2-5). Also, the new Schiff-base derivatives (6-10) were synthesized from the reaction of compound (1) with various aromatic aldehydes and the closure-ring was done successfully using mercapto acetic acid to get the new thiazolidine derivatives(11-12).These new compounds were characterized using some physical techniques like:FT-IR Spectra and 1HNMR Spectra.

The preparation of halogenotrimolybdate(II) compounds

1967 ◽  
Vol 20 (5) ◽  
pp. 869 ◽  
Author(s):  
GB Allison ◽  
IR Anderson ◽  
JC Sheldon
Keyword(s):  
Acetic Acid ◽  
Ammonium Chloride ◽  
Redox Reaction ◽  
Rapid Reaction ◽  
New Compounds

The preparation of halogenotrimolybdate(II) compounds containing the staphylonuclear groups, (Mo3Cl13)7-, (Mo3Br13)7-, (Mo3Cl12)6-,(Mo3Cl11)5-, (Mo3Br11)5-, (Mo3Br11)5- has been thoroughly examined and 11 new compounds are reported. No iodomolybdate(II) compounds were observed. When (NH4)7Mo3Cl13,H2O is heated in vacuum, ammonium chloride is evolved but the final product is never MoCl2. This chloromolybdate(II) undergoes rapid reaction with refluxing acetic acid to give an approximately two-thirds yield of molybdenum(II) acetate. This suggests the cleaving of an Mo3 group to give Mo2(CH3CO2)4. Crystalline [Co en3]3Mo3Cl15,6H2O undergoes spontaneous intramolecular redox reaction which is stimulated by light, or moisture, but not oxygen.

Synthesis of trisubstituted ethylenes of the furan series based on 5-methoxycarbonyl-2-furfuryl trichloromethyl sulfone

1980 ◽  
Vol 45 (3) ◽  
pp. 746-751 ◽  
Author(s):  
Adolf Jurášek ◽  
Jaroslav Kováč ◽  
Rudolf Belko
Keyword(s):  
Acetic Acid ◽  
Ir Spectra ◽  
Ammonium Acetate ◽  
Furan Series ◽  
H Nmr ◽  
New Compounds

Condensation of 5-methoxycarbonyl-2-furfuryl trichloromethyl sulfone with 4-X-benzaldehydes (X = H, OH, OCH3, N(CH3)2, Cl, I, CN) or 5-Y-2-furaldehydes (Y = H, NO2) in acetic acid in the presence of ammonium acetate and piperidine afforded the corresponding 1-(5-methoxycarbonyl-2-furyl)-1-trichloromethylsulfonyl-2-arylethylenes (IIa-IIj). Structure of these new compounds is discussed on the basis of their UV, 1H-NMR and IR spectra.

Neuroleptics of the 8-methylthio-10-piperazino-10,11-dihydrodibenzo[b,f]thiepin series: New compounds and new procedures

1980 ◽  
Vol 45 (2) ◽  
pp. 504-516 ◽  
Author(s):  
Jiří Jílek ◽  
Josef Pomykáček ◽  
Antonín Dlabač ◽  
Marie Bartošová ◽  
Miroslav Protiva
Keyword(s):  
Acetic Acid ◽  
Amino Alcohol ◽  
Substitution Reaction ◽  
Decanoic Acid ◽  
Pharmacological Data ◽  
Long Acting ◽  
New Compounds ◽  
New Procedures

Heating of 8-methylthiodibenzo[b,f]thiepin-10(11H)-one with mono-p-toluenesulfonates of 1-methylpiperazine and piperazine in vacuo led in good yields to the enamines IX-XI, the first of which was reduced with zinc and acetic acid to the base I (methiothepin). The ester III(oxyprothepindecanoate) was obtained by reaction of the amino alcohol II (oxyprothepin) with decanoic acid in the presence of N,N'-carbonyldiimidazole and by substitution of 10-chloro-8-methylthio-10,11-dihydrobenzo[b,f]thiepin with 1-(3-decanoyloxypropyl)piperazine. The substitution reaction of the same chloro compound with piperazine gave two stereoisomeric 1,4-disubstituted piperazines V. Reaction of the amino alcohol II with octyl isocyanate afforded the carbamate VI, an isoster of oxyprothepin decanoate (III). This substance showed in the test of antiapomorphine activity in dogs the properties of a long-acting antiemetic. Two new potential metabolites (XII, XIII) of compounds I-III were synthesized and new pharmacological data are given for two further potential metabolites (XIV, XV) of oxyprothepin (II).

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