Inclusion Compounds in Pharmaceutical Analysis I: Determination of Dienestrol in Dienestrol Cream

1969 ◽  
Vol 58 (10) ◽  
pp. 1262-1265 ◽  
Author(s):  
Barbara J. Forman ◽  
Lee T. Grady
Keyword(s):  
Inclusion Compounds ◽  
Pharmaceutical Analysis

Recent Applications of High Performance Thin Layer Chromatography and Derivative Spectrophotometry in Pharmaceutical Analysis

2020 ◽  
Vol 16 (6) ◽  
pp. 671-689
Author(s):  
Marcin Gackowski ◽  
Marcin Koba ◽  
Katarzyna Mądra-Gackowska ◽  
Piotr Kośliński ◽  
Stefan Kruszewski
Keyword(s):  
Thin Layer ◽  
Thin Layer Chromatography ◽  
Pharmaceutical Analysis ◽  
High Performance ◽  
Degradation Products ◽  
Derivative Spectrophotometry ◽  
Accuracy And Precision ◽  
Post Marketing ◽  
Layer Chromatography

At present, no one can imagine drug development, marketing and post-marketing without rigorous quality control at each stage. Only modern, selective, accurate and precise analytical methods for determination of active compounds, their degradation products and stability studies are able to assure the appropriate amount and purity of drugs administered every day to millions of patients all over the world. For routine control of drugs simple, economic, rapid and reliable methods are desirable. The major focus of current scrutiny is placed on high-performance thin layer chromatography and derivative spectrophotometry methods, which fulfill routine drug estimation’s expectations [1-4]. The present paper reveals state-of-the-art and possible applications of those methods in pharmaceutical analysis between 2010 and 2018. The review shows advantages of high-performance thin layer chromatography and derivative spectrophotometry, including accuracy and precision comparable to more expensive and time-consuming methods as well as additional fields of possible applications, which contribute to resolving many analytical problems in everyday laboratory practice.

Development of laser ablation dielectric barrier discharge optical emission spectrometry (LA-DBD-OES) for direct determination of sulphur and chloride in condensed phase and its application in pharmaceutical analysis

The Analyst ◽  
2021 ◽  
Author(s):  
Xuelu Ding ◽  
Chaoqun Geng ◽  
Suhan Zhai ◽  
Xiaoyan Cao ◽  
Zhenyan Shi ◽  
...  
Keyword(s):  
Laser Ablation ◽  
Dielectric Barrier Discharge ◽  
Organic Compounds ◽  
Pharmaceutical Analysis ◽  
Barrier Discharge ◽  
Direct Determination ◽  
Optical Emission ◽  
Emission Spectrometry ◽  
Dielectric Barrier

An infrared laser (808 nm) has been coupled with dielectric barrier discharge (DBD) for optical emission spectrometric determination of S and Cl in organic compounds. The use of a continuous...

scholarly journals Validation and Quality Assurance of Planar Chromatographic Procedures in Pharmaceutical Analysis

2001 ◽  
Vol 84 (4) ◽  
pp. 1265-1276 ◽  
Author(s):  
Katalin Ferenczi-Fodor ◽  
Zoltán Végh ◽  
Anikó Nagy-Turák ◽  
Bernd Renger ◽  
Marco Zeller
Keyword(s):  
Quality Assurance ◽  
Pharmaceutical Analysis ◽  
Control Charts ◽  
Practical Experience ◽  
Standardized Terminology ◽  
Criteria For Evaluation ◽  
Formal Requirements ◽  
Determination Of Impurities ◽  
Validation Experiments

Abstract Within the process of the International Conference on Harmonization (ICH), 2 guidelines were released containing a standardized terminology, a verified model of requirements for the validation of analytical procedures, and some guidance in the practical aspects of conducting validation studies in pharmaceutical analysis. For planar chromatographic procedures, which may be used at different levels either in qualitative identity testing, assays, semiquantitative limit tests, or quantitative determination of impurities, this paper tries to transfer these formal requirements into practical approaches for validation. Basic acceptance criteria for evaluation of validation experiments based on practical experience are proposed. In addition, selected parameters for robustness testing of given procedures and quality assurance of quantitative planar chromatographic testing by control charts is described.

Liquid Chromatography in Pharmaceutical Analysis IV: Determination of Antispasmodic Mixtures

1975 ◽  
Vol 64 (8) ◽  
pp. 1389-1393 ◽  
Author(s):  
I.L. Honigberg ◽  
J.T. Stewart ◽  
A.P. Smith ◽  
R.D. Plunkett ◽  
E.L. Justice
Keyword(s):  
Liquid Chromatography ◽  
Pharmaceutical Analysis

Structures and Photochemistry of Inclusion Compounds of 9,10-Dihydro-9,10-ethenoanthracene-11,12-bis(diphenylphosphine Oxide)

1997 ◽  
Vol 53 (2) ◽  
pp. 293-299 ◽  
Author(s):  
T. Y. Fu ◽  
Z. Liu ◽  
G. Olovsson ◽  
J. R. Scheffer ◽  
J. Trotter
Keyword(s):  
Solid State ◽  
Single Crystals ◽  
Crystal Structures ◽  
Inclusion Compounds ◽  
Enantiomeric Excess ◽  
Structural Features ◽  
Host Molecule ◽  
Diphenylphosphine Oxide ◽  
Solvent Molecules

Inclusion complexes of 9,10-dihydro-9,10-etheno-anthracene-11,12-bis(diphenylphosphine oxide) (1) as host are synthesized using a variety of guest solvent molecules and the photochemistry of the host molecule is studied in solution and in the crystalline complexes. The crystal structures of four complexes are determined and correlated with their photochemical reactivity. In each case only one dibenzosemibullvalene photoproduct is obtained in the photolysis. Since three of the complexes studied crystallize in the chiral space group P212121, irradiation of single crystals produces a chiral photoproduct in >90% enantiomeric excess. Determination of the absolute configurations of reactants and products allows elucidation of the key structural features that control the enantiospecific solid-state photorearrangements.

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