Liquid Chromatography in Pharmaceutical Analysis IV: Determination of Antispasmodic Mixtures

1975 ◽  
Vol 64 (8) ◽  
pp. 1389-1393 ◽  
Author(s):  
I.L. Honigberg ◽  
J.T. Stewart ◽  
A.P. Smith ◽  
R.D. Plunkett ◽  
E.L. Justice
Keyword(s):  
Liquid Chromatography ◽  
Pharmaceutical Analysis

Liquid Chromatography in Pharmaceutical Analysis VI: Determination of Dantrolene Sodium in a Dosage Form

1977 ◽  
Vol 66 (2) ◽  
pp. 286-288 ◽  
Author(s):  
S.J. Saxena ◽  
I.L. Honigberg ◽  
J.T. Stewart ◽  
G.R. Keene ◽  
J.J. Vallner
Keyword(s):  
Liquid Chromatography ◽  
Pharmaceutical Analysis ◽  
Dosage Form ◽  
Dantrolene Sodium

scholarly journals Recent theoretical and practical applications of micellar liquid chromatography (MLC) in pharmaceutical and biomedical analysis

2012 ◽  
Vol 10 (3) ◽  
pp. 570-584 ◽  
Author(s):  
Piotr Kawczak ◽  
Tomasz Bączek
Keyword(s):  
Liquid Chromatography ◽  
Pharmaceutical Analysis ◽  
Micellar Liquid Chromatography ◽  
Biologically Active ◽  
Organic Modifiers ◽  
Active Compounds ◽  
Separation Techniques ◽  
Practical Applications ◽  
Wide Range

AbstractMicellar liquid chromatography (MLC) is an analytical technique belonging to the wide range of reversed-phase liquid chromatographic (RP-LC) separation techniques. MLC with the use of surfactant solutions above its critical micellar concentration (CMC) and the addition of organic modifiers is currently an important analytical tool with still growing theoretical considerations and practical applications in pharmaceutical analysis of drugs and other biologically active compounds. The use of MLC as an alternative, relatively much faster in comparison to conventional chromatographic separation techniques has several advantages, especially as being suitable for screening pharmaceutical analysis. The analytical data received from MLC analysis are considered a useful source of information to predict passive drug absorption, drug transport and other pharmacokinetics and physicochemical measures of pharmaceutical substances. In the review several MLC assays for determination of drugs and other active compounds in biological samples were compared and critically discussed. The presented overview provides information on recent applications and achievements connected with the practical use of MLC. The review covers fields of interest related to theory and mechanism of MLC separation, direct applications of MLC in pharmaceutical analysis, including optimization and efficiency of separation with the use of modification of stationary phase and mobile phase compositions as well as the determination of physicochemical characteristics of drugs by MLC.

Liquid Chromatography in Pharmaceutical Analysis II: Determination of a Reserpine–Chlorothiazide Mixture

1974 ◽  
Vol 63 (11) ◽  
pp. 1762-1764 ◽  
Author(s):  
I.L. Honigberg ◽  
J.T. Stewart ◽  
A.P. Smith ◽  
R.D. Plunkett ◽  
D.W. Hester
Keyword(s):  
Liquid Chromatography ◽  
Pharmaceutical Analysis

scholarly journals Applicability of Capillary Gas-Liquid Chromatography for Determination of Parabens in Pharmaceutical Analysis

2019 ◽  
Vol 9 (2) ◽  
pp. 123-130
Author(s):  
A. N. Ioutsi ◽  
M. A. Sumtsov ◽  
D. A. Artyushenko ◽  
D. V. Bychenkov ◽  
A. N. Blinov
Keyword(s):  
Liquid Chromatography ◽  
Pharmaceutical Analysis ◽  
Packed Column ◽  
Pharmaceutical Products ◽  
Test Method ◽  
Gas Liquid Chromatography ◽  
Medicinal Products ◽  
Component Mixture ◽  
Limit Of Quantitation

The traditional gas-liquid chromatography (GLC) method using packed columns is still used in pharmaceutical analysis for determination of parabens, despite the fact that this technique has a number of serious drawbacks.The aim of the study was to develop a more effective capillary GLC method for determination of parabens in active pharmaceutical ingredients and finished pharmaceutical products.Materials and methods: the study was performed using Agilent 6890N and Agilent 7890B systems with flame-ionisation detectors. The systems were equipped with Agilent 7683B and Agilent G4513A autosamplers, respectively. The following columns were used in the study: ZB-1 15 m х 0.32 mm х 0.25 pm, DB-1 30 m х 0.32 mm х 3.0 pm, Cp-Sil 5-CB 30 m х 0.32 mm х 3.0 pm.Results: the authors developed a method for methylparaben and propylparaben determination using capillary column GLC. The chromatographic parameters (chromatographic system performance, reproducibility of peak areas, peak asymmetry) were determined for both capillary and packed column GLC. The authors outlined the prospects for simultaneous determination of several compounds using the proposed method: a four-component mixture containing methyl-, ethyl-, propyl-, and butylparaben was separated in 9 minutes. The authors used Loma Lux Psoriasis to perform partial validation of the test method. They determined the linearity range and the limit of quantitation for methylparaben and propylparaben, and verified accuracy and intermediate precision of the test method.Conclusions: the results of the study allowed for selection of optimal chromatographic conditions for rapid and high-precision determination of methylparaben and propylparaben in medicinal products. The developed method is recommended for control of the content of these compounds in medicinal products.

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