Solid/Hollow Depots for Drug Delivery, Part 1: Effect of Drug Characteristics and Polymer Molecular Weight on the Phase-Inversion Dynamics, Depot Morphology, and Drug Release

2014 ◽  
Vol 103 (2) ◽  
pp. 485-495 ◽  
Author(s):  
Hui Liu ◽  
Subbu S. Venkatraman
Keyword(s):  
Drug Delivery ◽  
Molecular Weight ◽  
Drug Release ◽  
Phase Inversion ◽  
Polymer Molecular Weight

Effects of drug and polymer molecular weight on drug release from PLGA-mPEG microspheres

2014 ◽  
Vol 132 (6) ◽  
pp. n/a-n/a ◽  
Author(s):  
Shuibin Feng ◽  
Lei Nie ◽  
Peng Zou ◽  
Jinping Suo
Keyword(s):  
Molecular Weight ◽  
Drug Release ◽  
Polymer Molecular Weight

Drug Release Kinetic Analysis and Prediction of Release Data via Polymer Molecular Weight in Sustained Release Diltiazem Matrices

Drug Research ◽  
2013 ◽  
Vol 64 (03) ◽  
pp. 118-123 ◽  
Author(s):  
K. Adibkia ◽  
S. Ghanbarzadeh ◽  
G. Mohammadi ◽  
H. Khiavi ◽  
A. Sabzevari ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Drug Release ◽  
Sustained Release ◽  
Kinetic Analysis ◽  
Release Kinetic ◽  
Polymer Molecular Weight ◽  
Release Data ◽  
Drug Release Kinetic

Nanoparticles-in-soft microagglomerates as oral colon-specific cancer therapeutic vehicle

2021 ◽  
Author(s):  
Nafisah Musa ◽  
Tin Wui Wong
Keyword(s):  
Drug Delivery ◽  
Molecular Weight ◽  
Colon Cancer ◽  
Drug Release ◽  
Primary Therapy ◽  
Specific Drug ◽  
Nanoparticle Aggregation ◽  
Cancer Chemotherapeutics ◽  
Colon Specific Drug Delivery ◽  
Upper Gastrointestinal

Polymeric nanoparticles can be conjugated with targeting ligand such as folate to elicit oral colon-specific drug delivery to treat colon cancer. Oral chemotherapy can be used as adjuvant, neo-adjuvant, or primary therapy. Nonetheless, oral cancer chemotherapeutics may experience premature drug release at the upper gastrointestinal tract due to the availability of a large specific dissolution surface area of nanoparticles leading to failure in colon cancer targeting. This study designed soft microagglomerates as carrier of nanoparticles to delay drug release. High molecular weight chitosan/pectin with covalent 5-fluorouracil/folate was processed into nanoparticles. Low molecular weight chitosan was spray-dried into nanoparticle aggregation vehicle. The soft agglomerates were produced by blending of nanoparticles and aggregation vehicle in specific weight ratios through vortex method. Adding aggregation vehicle promoted soft agglomeration with nanoparticles deposited onto its surfaces with minimal binary coalescence. Soft agglomerates prepared from 10:18 weight ratio of nanoparticles to nanoparticle aggregation vehicle using 1% chitosan solution concentration reduced the propensity of premature drug release of nanoparticles in the upper gastrointestinal region. Soft agglomerates reduced early drug release of cancer chemotherapeutics and was responsive to intracapsular sodium alginate coat to further sustain drug release. The soft microagglomerates are a viable dosage form in colon-specific drug delivery. Further study will focus on investigating intracapsular-coated soft agglomerates in vivo pharmacokinetics and pharmacodynamics behaviours with respect to local colorectal cancer.

Synthesis, Influence of Polymer Molecular Weight on Drug Release and Anti-HIV Activity of PEGylated AZT Conjugates

2011 ◽  
Vol 90 (2) ◽  
pp. A37
Author(s):  
Wenjun Li ◽  
Peng Zhan ◽  
Jingde Wu ◽  
Yu Chang ◽  
Christophe Pannecouque ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Drug Release ◽  
Polymer Molecular Weight ◽  
Anti Hiv

Phase Inversion Dynamics of PLGA Solutions Related to Drug Delivery

1998 ◽  
Vol 550 ◽  
Author(s):  
A.J. Mchugh ◽  
P.D. Graham ◽  
K.J. Brodbeck
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Release Rate ◽  
Phase Inversion ◽  
In Vitro Drug Release ◽  
Water Influx ◽  
Initial Release ◽  
Dark Ground ◽  
Initial Drug

AbstractDark ground optical microscopy, electron microscopy, and protein release rate studies have been used to quantify the effects of formulation changes on the phase inversion dynamics and in vitro drug release properties of an injectable PLGA-based drug delivery system. Gel growth rates and water influx rates are determined from plots of the square of the respective front with time. Results show that additives that increase the solution gelation rate and produce finger-like void morphologies result in higher initial release rates. Conversely, additives that slow the rate of gelation dramatically reduce the initial drug release rate and lead to a more dense sponge-like morphology.

scholarly journals Synthesis of a PVA drug delivery system for controlled release of a Tramadol–Dexketoprofen combination

2021 ◽  
Vol 32 (5) ◽  
Author(s):  
Juan Carlos Flores-Arriaga ◽  
Daniel Chavarría-Bolaños ◽  
Amaury de Jesús Pozos-Guillén ◽  
Vladimir Alonso Escobar-Barrios ◽  
Bernardino Isaac Cerda-Cristerna
Keyword(s):  
Drug Delivery ◽  
Molecular Weight ◽  
Citric Acid ◽  
Postoperative Pain ◽  
Drug Release ◽  
Release Rate ◽  
Poly Vinyl Alcohol ◽  
Prolonged Release ◽  
Scanning Calorimetry ◽  
Drug Release Rate

AbstractThe local administration of analgesic combinations by means of degradable polymeric drug delivery systems is an alternative for the management of postoperative pain. We formulated a Tramadol–Dexketoprofen combination (TDC) loaded in poly(vinyl alcohol) (PVA) film. Films were prepared by the solvent casting method using three different molecular weights of PVA and crosslinking those films with citric acid, with the objective of controlling the drug release rate, which was evaluated by UV–vis spectrometry. Non-crosslinked PVA films were also evaluated in the experiments. Differential scanning calorimetry (DSC) analysis of samples corroborated the crosslinking of PVA by the citric acid. Blank and loaded PVA films were tested in vitro for its impact on blood coagulation prothrombin time (PT) and partial thromboplastin time (PTT). The swelling capacity was also evaluated. Crosslinked PVA films of higher-molecular weight showed a prolonged release rate compared with that of the lower-molecular-weight films tested. Non-crosslinked PVA films released 11–14% of TDC. Crosslinked PVA films released 80% of the TDC loaded (p < 0.05). This suggests that crosslinking films can modify the drug release rate. The blank and loaded PVA films induced PT and PTT in the normal range. The results showed that the polymeric films evaluated here have the appropriate properties to allow films to be placed directly on surgical wounds and have the capacity for controlled drug release to promote local analgesia for the control of postoperative pain.

How subtle differences in polymer molecular weight affect doxorubicin-loaded PLGA nanoparticles degradation and drug release

2020 ◽  
Vol 37 (3) ◽  
pp. 283-295 ◽  
Author(s):  
Natalya Kumskova ◽  
Yulia Ermolenko ◽  
Nadezhda Osipova ◽  
Aleksey Semyonkin ◽  
Natalia Kildeeva ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Drug Release ◽  
Plga Nanoparticles ◽  
Polymer Molecular Weight

Liposomes

2017 ◽  
pp. 27-51
Author(s):  
Ljiljana Djekic
Keyword(s):  
Drug Delivery ◽  
Molecular Weight ◽  
Drug Release ◽  
Premature Infants ◽  
Therapeutic Index ◽  
Cytotoxic Drugs ◽  
New Drugs ◽  
Sustained Drug Release ◽  
Routes Of Administration ◽  
Drug Substances

This chapter reviews the current progress in liposome based pharmaceuticals with particular emphasis on the carrier design, size, surface properties, drug delivery performances and therapeutic applications for different routes of administration. There were described selected examples of encapsulation of drug substances by liposomes which allowed improvement of therapeutic index of cytotoxic drugs (such as antineoplastics, antibiotics) or sustained drug release and reduction of the frequency of administration of analgesics and local anesthetics, and potentiate the immunogenicity of vaccines against hepatitis A and influenza. Furthermore, the performances of the marketed pharmaceuticals which represent pulmonary surfactant substituents (in the form of liposome vesicles) in premature infants and topical preparations with high molecular weight actives (e.g., heparin sodium) encapsulated in liposomes, were highlighted. The most important factors that affect the development of new drugs with this type of nanomaterials and their safety were commented.

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