Effects of drug and polymer molecular weight on drug release from PLGA-mPEG microspheres

2014 ◽  
Vol 132 (6) ◽  
pp. n/a-n/a ◽  
Author(s):  
Shuibin Feng ◽  
Lei Nie ◽  
Peng Zou ◽  
Jinping Suo
Keyword(s):  
Molecular Weight ◽  
Drug Release ◽  
Polymer Molecular Weight

Drug Release Kinetic Analysis and Prediction of Release Data via Polymer Molecular Weight in Sustained Release Diltiazem Matrices

Drug Research ◽  
2013 ◽  
Vol 64 (03) ◽  
pp. 118-123 ◽  
Author(s):  
K. Adibkia ◽  
S. Ghanbarzadeh ◽  
G. Mohammadi ◽  
H. Khiavi ◽  
A. Sabzevari ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Drug Release ◽  
Sustained Release ◽  
Kinetic Analysis ◽  
Release Kinetic ◽  
Polymer Molecular Weight ◽  
Release Data ◽  
Drug Release Kinetic

Synthesis, Influence of Polymer Molecular Weight on Drug Release and Anti-HIV Activity of PEGylated AZT Conjugates

2011 ◽  
Vol 90 (2) ◽  
pp. A37
Author(s):  
Wenjun Li ◽  
Peng Zhan ◽  
Jingde Wu ◽  
Yu Chang ◽  
Christophe Pannecouque ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Drug Release ◽  
Polymer Molecular Weight ◽  
Anti Hiv

How subtle differences in polymer molecular weight affect doxorubicin-loaded PLGA nanoparticles degradation and drug release

2020 ◽  
Vol 37 (3) ◽  
pp. 283-295 ◽  
Author(s):  
Natalya Kumskova ◽  
Yulia Ermolenko ◽  
Nadezhda Osipova ◽  
Aleksey Semyonkin ◽  
Natalia Kildeeva ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Drug Release ◽  
Plga Nanoparticles ◽  
Polymer Molecular Weight

Crystallization of Isotactic Poly(propylene) in Solution as Followed by Slow Calorimetry

1995 ◽  
Vol 60 (11) ◽  
pp. 1905-1924 ◽  
Author(s):  
Hong Phuong-Nguyen ◽  
Geneviève Delmas
Keyword(s):  
Molecular Weight ◽  
Crystal Growth ◽  
High Temperature ◽  
Heat Of Fusion ◽  
Complete Dissolution ◽  
Polymer Molecular Weight ◽  
Solvent Quality ◽  
Temperature Ramp ◽  
Poly Propylene

Dissolution, crystallization and second dissolution traces of isotactic poly(propylene) have been obtained in a slow temperature ramp (3 K h-1) with the C80 Setaram calorimeter. Traces of phase-change, in presence of solvent, are comparable to traces without solvent. The change of enthalpy on heating or cooling, ∆Htotal, over the 40-170 °C temperature range, is the sum of two contributions, ∆HDSC and ∆Hnetwork. The change ∆HDSC is the usual heat obtained in a fast temperature ramp and ∆Hnetwork is associated with a physical network whose disordering is slow and subject to superheating due to strain. When dissolution is complete, ∆Htotal is equal to ∆H0, the heat of fusion of perfect crystals. The values of ∆Htota for nascent and recrystallized samples are compared. Dissolution is the tool to evaluate the quality of the crystals. The repartition of ∆Htotal, into the two endotherms, reflects the quality of crystals. The crystals grown more rapidly have a higher fraction of network crystals which are stable at high T in the solvents. A complete dissolution, i.e. a high temperature (170 °C or more) is necessary to obtain good crystals. The effect of concentration, polymer molecular weight and solvent quality on crystal growth is analyzed.

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