Simultaneous Absolute Quantification of 11 Cytochrome P450 Isoforms in Human Liver Microsomes by Liquid Chromatography Tandem Mass Spectrometry with In Silico Target Peptide Selection

2011 ◽  
Vol 100 (1) ◽  
pp. 341-352 ◽  
Author(s):  
Hirotaka Kawakami ◽  
Sumio Ohtsuki ◽  
Junichi Kamiie ◽  
Takashi Suzuki ◽  
Takaaki Abe ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Cytochrome P450 ◽  
Liquid Chromatography ◽  
Human Liver ◽  
Liver Microsomes ◽  
Absolute Quantification ◽  
Tandem Mass ◽  
Chromatography Tandem Mass Spectrometry ◽  
Cytochrome P450 Isoforms ◽  
Liquid Chromatography Tandem Mass

scholarly journals Reactive intermediates in naquotinib metabolism identified by liquid chromatography-tandem mass spectrometry: phase I metabolic profiling

RSC Advances ◽  
2019 ◽  
Vol 9 (18) ◽  
pp. 10211-10225 ◽  
Author(s):  
Mohamed W. Attwa ◽  
Adnan A. Kadi ◽  
Haitham AlRabiah ◽  
Hany W. Darwish
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Metabolic Profiling ◽  
Human Liver ◽  
Liver Microsomes ◽  
Reactive Intermediates ◽  
Tandem Mass ◽  
Chromatography Tandem Mass Spectrometry ◽  
Liquid Chromatography Tandem Mass

LC-MS/MS was used to screen for in vitro metabolites of NQT formed during incubation with human liver microsomes (HLMs) and then evaluated the generation of reactive electrophiles using capturing agents.

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