Non-invasive Systemic Drug Delivery: Developability Considerations for Alternate Routes of Administration

2010 ◽  
Vol 99 (1) ◽  
pp. 1-20 ◽  
Author(s):  
Neil R. Mathias ◽  
Munir A. Hussain
Keyword(s):  
Drug Delivery ◽  
Routes Of Administration ◽  
Non Invasive ◽  
Systemic Drug Delivery ◽  
Alternate Routes ◽  
Systemic Drug

scholarly journals Non-invasive systemic drug delivery through mucosal routes

2018 ◽  
Vol 46 (sup2) ◽  
pp. 539-551 ◽  
Author(s):  
Amit K. Goyal ◽  
Ranjit Singh ◽  
Gaurav Chauhan ◽  
Goutam Rath
Keyword(s):  
Drug Delivery ◽  
Non Invasive ◽  
Systemic Drug Delivery ◽  
Systemic Drug

Formulating SLN and NLC as Innovative Drug Delivery Systems for Non-Invasive Routes of Drug Administration

2020 ◽  
Vol 27 (22) ◽  
pp. 3623-3656 ◽  
Author(s):  
Bruno Fonseca-Santos ◽  
Patrícia Bento Silva ◽  
Roberta Balansin Rigon ◽  
Mariana Rillo Sato ◽  
Marlus Chorilli
Keyword(s):  
Drug Delivery ◽  
Particle Size ◽  
Drug Release ◽  
Drug Loading ◽  
Average Particle Size ◽  
Delivery Systems ◽  
Average Particle ◽  
Minor Importance ◽  
Routes Of Administration ◽  
Non Invasive

Colloidal carriers diverge depending on their composition, ability to incorporate drugs and applicability, but the common feature is the small average particle size. Among the carriers with the potential nanostructured drug delivery application there are SLN and NLC. These nanostructured systems consist of complex lipids and highly purified mixtures of glycerides having varying particle size. Also, these systems have shown physical stability, protection capacity of unstable drugs, release control ability, excellent tolerability, possibility of vectorization, and no reported production problems related to large-scale. Several production procedures can be applied to achieve high association efficiency between the bioactive and the carrier, depending on the physicochemical properties of both, as well as on the production procedure applied. The whole set of unique advantages such as enhanced drug loading capacity, prevention of drug expulsion, leads to more flexibility for modulation of drug release and makes Lipid-based nanocarriers (LNCs) versatile delivery system for various routes of administration. The route of administration has a significant impact on the therapeutic outcome of a drug. Thus, the non-invasive routes, which were of minor importance as parts of drug delivery in the past, have assumed added importance drugs, proteins, peptides and biopharmaceuticals drug delivery and these include nasal, buccal, vaginal and transdermal routes. The objective of this paper is to present the state of the art concerning the application of the lipid nanocarriers designated for non-invasive routes of administration. In this manner, this review presents an innovative technological platform to develop nanostructured delivery systems with great versatility of application in non-invasive routes of administration and targeting drug release.

scholarly journals An experimental platform for systemic drug delivery to the retina

2009 ◽  
Vol 106 (42) ◽  
pp. 17817-17822 ◽  
Author(s):  
M. Campbell ◽  
A. T. H. Nguyen ◽  
A.-S. Kiang ◽  
L. C. S. Tam ◽  
O. L. Gobbo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Experimental Platform ◽  
Systemic Drug Delivery ◽  
Systemic Drug

Advances in local and systemic drug delivery systems for post-surgical cancer treatment

2020 ◽  
Vol 8 (37) ◽  
pp. 8507-8518
Author(s):  
Md Aquib ◽  
Ajkia Zaman Juthi ◽  
Muhammad Asim Farooq ◽  
Manasik Gumah Ali ◽  
Alhamzah Hasan Waheed Janabi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Treatment ◽  
Drug Delivery Systems ◽  
Graphical Representation ◽  
Delivery Systems ◽  
Systemic Drug Delivery ◽  
Systemic Drug

Graphical representation of local and systemic drug delivery systems.

Topical and systemic drug delivery to the posterior segments

2005 ◽  
Vol 57 (14) ◽  
pp. 2010-2032 ◽  
Author(s):  
P HUGHES ◽  
O OLEJNIK ◽  
J CHANGLIN ◽  
C WILSON
Keyword(s):  
Drug Delivery ◽  
Systemic Drug Delivery ◽  
Systemic Drug

Drug Delivery: Virus-Inspired Mimics Based on Dendritic Lipopeptides for Efficient Tumor-Specific Infection and Systemic Drug Delivery (Adv. Funct. Mater. 33/2015)

2015 ◽  
Vol 25 (33) ◽  
pp. 5241-5241
Author(s):  
Zhijun Zhang ◽  
Xiao Zhang ◽  
Xianghui Xu ◽  
Yunkun Li ◽  
Yachao Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Systemic Drug Delivery ◽  
Systemic Drug
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