Sulfobutyl ether-alkyl ether mixed cyclodextrin derivatives with enhanced inclusion ability

2009 ◽  
Vol 98 (12) ◽  
pp. 4769-4780 ◽  
Author(s):  
Serena Tongiani ◽  
Tetsuya Ozeki ◽  
Valentino J. Stella
Keyword(s):  
Alkyl Ether ◽  
Cyclodextrin Derivatives ◽  
Sulfobutyl Ether ◽  
Inclusion Ability

scholarly journals Associated-Extraction Efficiency of Six Cyclodextrins on Various Flavonoids in Puerariae Lobatae Radix

Molecules ◽  
2018 ◽  
Vol 24 (1) ◽  
pp. 93 ◽  
Author(s):  
Tao Feng ◽  
Fan Liu ◽  
Lili Sun ◽  
Hongna Huo ◽  
Xiaoliang Ren ◽  
...  
Keyword(s):  
High Performance ◽  
Water Solubility ◽  
Extraction Efficiency ◽  
Cerebrovascular Diseases ◽  
Water Soluble ◽  
Cyclodextrin Derivatives ◽  
Treatment And Prevention ◽  
Promising Application ◽  
Sulfobutyl Ether ◽  
Processed Products

Puerariae Lobatae Radix (PLR), a well-known herbal medicine, is the root of Pueraria lobata (Willd.) Ohwi and has been employed for the treatment and prevention of cardiovascular and cerebrovascular diseases. The purpose of this study was to compare the associated-extraction efficiency of six cyclodextrins (CDs) on five flavonoids in PLR, namely puerarin, daidzein, daidzin, genistein and genistin, which are the major secondary metabolites, and exhibit low water solubility. The six CDs applied were β-cyclodextrin (β-CD), γ-cyclodextrin (γ-CD), hydroxypropyl-β-cyclodextrin (HP-β-CD), hydroxypropyl-γ-cyclodextrin (HP-γ-CD), carboxymethyl-β-cyclodextrin (CM-β-CD), and sulfobutyl ether β-cyclodextrin (SBE-β-CD). They can be grouped into one of the following three categories: traditional cyclodextrins (β-CD and γ-CD), water-soluble cyclodextrin derivatives (HP-β-CD and HP-γ-CD) and ionic cyclodextrin derivatives (SBE-β-CD and CM-β-CD). High-performance liquid chromatography (HPLC) was used to analyze the five flavonoids in the original aqueous extracts (OAE) in the presence or absence of various CDs. The associated-extraction efficiency of the various CDs followed the ranking: SBE-β-CD > HP-β-CD > CM-β-CD > HP-γ-CD > γ-CD > β-CD. It was clear that SBE-β-CD presented the highest associated-extraction capability, and it was used to extract the four flavonoids from three PLR products, including raw product, stir- fried product, and product simmered with wheat bran. The results showed that SBE-β-CD could improve the extraction capability of flavonoids, both from the raw product and in processed products of PLR. In conclusion, CDs, especially SBE-β-CD, have a promising application for the associated-extraction of flavonoids from PLR.

Synthesis of novel cyclodextrin derivatives by aromatic spacer insertion and their inclusion ability

Tetrahedron ◽  
2005 ◽  
Vol 61 (24) ◽  
pp. 5763-5768 ◽  
Author(s):  
Toshiyuki Kida ◽  
Akira Kikuzawa ◽  
Hiroyuki Higashimoto ◽  
Yohji Nakatsuji ◽  
Mitsuru Akashi
Keyword(s):  
Cyclodextrin Derivatives ◽  
Inclusion Ability

Sulfoalkyl Ether-Alkyl Ether Cyclodextrin Derivatives, their Synthesis, NMR Characterization, and Binding of 6α-Methylprednisolone

2005 ◽  
Vol 94 (11) ◽  
pp. 2380-2392 ◽  
Author(s):  
Serena Tongiani ◽  
David Vander Velde ◽  
Tetsuya Ozeki ◽  
Valentino J. Stella
Keyword(s):  
Alkyl Ether ◽  
Cyclodextrin Derivatives ◽  
Nmr Characterization

The synthesis and process optimization of sulfobutyl ether β-cyclodextrin derivatives

Tetrahedron ◽  
2016 ◽  
Vol 72 (22) ◽  
pp. 3105-3112 ◽  
Author(s):  
Dong-Ya Ma ◽  
Yi-Min Zhang ◽  
Jing-Na Xu
Keyword(s):  
Process Optimization ◽  
Cyclodextrin Derivatives ◽  
Sulfobutyl Ether

Short Synthesis of Skeleton-Modified Cyclodextrin Derivatives with Unique Inclusion Ability

2005 ◽  
Vol 70 (4) ◽  
pp. 1253-1261 ◽  
Author(s):  
Akira Kikuzawa ◽  
Toshiyuki Kida ◽  
Yohji Nakatsuji ◽  
Mitsuru Akashi
Keyword(s):  
Cyclodextrin Derivatives ◽  
Modified Cyclodextrin ◽  
Short Synthesis ◽  
Inclusion Ability
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