Pharmacokinetic and Pharmacodynamic Evaluation of the Suitability of Using Fluticasone and an Acute Rat Lung Inflammation Model to Differentiate Lung Versus Systemic Efficacy

2009 ◽  
Vol 98 (11) ◽  
pp. 4354-4364 ◽  
Author(s):  
Po-Chang Chiang ◽  
Yiding Hu ◽  
Archie Thurston ◽  
Cynthia D. Sommers ◽  
Julia A. Guzova ◽  
...  
Keyword(s):  
Lung Inflammation ◽  
Rat Lung ◽  
Inflammation Model

Enhanced Anti-Inflammation of Inhaled Dexamethasone Palmitate Using Mannosylated Liposomes in an Endotoxin-Induced Lung Inflammation Model

2008 ◽  
Vol 74 (5) ◽  
pp. 1183-1192 ◽  
Author(s):  
Wassana Wijagkanalan ◽  
Yuriko Higuchi ◽  
Shigeru Kawakami ◽  
Mugen Teshima ◽  
Hitoshi Sasaki ◽  
...  
Keyword(s):  
Lung Inflammation ◽  
Inflammation Model ◽  
Dexamethasone Palmitate ◽  
Mannosylated Liposomes ◽  
Anti Inflammation

scholarly journals PEG-fDAO Reduces Lung Inflammation in Chronic Granulomatous Disease Mice Post Challenge with Nonviable Candida Albicans

2021 ◽  
Author(s):  
Hiroyuki Nunoi ◽  
Peiyu Xie ◽  
Hideaki Nakamura ◽  
Yasuaki Aratani ◽  
Jun Fang ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Amino Acid ◽  
Chronic Granulomatous Disease ◽  
Lung Inflammation ◽  
Acid Oxidase ◽  
Granulomatous Disease ◽  
Amino Acid Oxidase ◽  
Lung Weight ◽  
Inflammation Model

Abstract We previously reported that polyethylene glycol-conjugated recombinant porcine D-amino acid oxidase (PEG-pDAO) could supply reactive oxygen species (ROS) to defective NADPH oxidase in neutrophils of patients with chronic granulomatous disease (CGD), and neutrophils regain bactericidal activity in vitro. In the present study, we employed an in vivo nonviable Candida albicans (nCA)-induced lung inflammation model using gp91-phox knockout CGD mice and novel PEG conjugates of Fusarium spp. D-amino acid oxidase (PEG-fDAO), rather than PEG-pDAO. Using three experimentation strategies with the in vivo lung inflammation model, the mouse body weight, lung weight, and lung pathology were evaluated to confirm the efficacy of ROS-generating enzyme replacement therapy with PEG-fDAO. The lung weight and pathological findings were significantly ameliorated by the administration of PEG-fDAO followed by intraperitoneal injection of D-phenylalanine or D-proline. These data suggest that PEG- fDAO with the function of targeted delivery to the nCA-induced inflammation site is applicable in the treatment of inflammation in CGD in vivo.

scholarly journals Eotaxin and eotaxin receptor (CCR3) expression in Sephadex particle-induced rat lung inflammation

2001 ◽  
Vol 80 (3) ◽  
pp. 177-185 ◽  
Author(s):  
Harrington ◽  
Newton ◽  
Williams ◽  
Hunt ◽  
Dearman ◽  
...  
Keyword(s):  
Lung Inflammation ◽  
Rat Lung

scholarly journals Strain Differences in Alveolar Neutrophil Infiltration and Macrophage Phenotypes in an Acute Lung Inflammation Model

2011 ◽  
Vol 17 (7-8) ◽  
pp. 780-789 ◽  
Author(s):  
Yinzhong Zhang ◽  
Xinchun Lin ◽  
Kiyokazu Koga ◽  
Koichiro Takahashi ◽  
Helena M Linge ◽  
...  
Keyword(s):  
Lung Inflammation ◽  
Strain Differences ◽  
Neutrophil Infiltration ◽  
Acute Lung Inflammation ◽  
Inflammation Model ◽  
Macrophage Phenotypes

scholarly journals PEG-fDAO Reduces Lung Inflammation in Chronic Granulomatous Disease Mice Post Challenge With Nonviable Candida Albicans

2021 ◽  
Author(s):  
Hiroyuki Nunoi ◽  
Peiyu Xie ◽  
Hideaki Nakamura ◽  
Yasuaki Aratani ◽  
Jun Fang ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Amino Acid ◽  
Chronic Granulomatous Disease ◽  
Lung Inflammation ◽  
Acid Oxidase ◽  
Granulomatous Disease ◽  
Amino Acid Oxidase ◽  
Lung Weight ◽  
Inflammation Model

Abstract We previously reported that polyethylene glycol-conjugated recombinant porcine D-amino acid oxidase (PEG-pDAO) could supply reactive oxygen species (ROS) to defective NADPH oxidase in neutrophils of patients with chronic granulomatous disease (CGD), and neutrophils regain bactericidal activity in vitro. In the present study, we employed an in vivo nonviable Candida albicans (nCA)-induced lung inflammation model using gp91-phox knockout CGD mice and novel PEG conjugates of Fusarium spp. D-amino acid oxidase (PEG-fDAO), rather than PEG-pDAO. Using three experimentation strategies with the in vivo lung inflammation model, the mouse body weight, lung weight, and lung pathology were evaluated to confirm the efficacy of ROS-generating enzyme replacement therapy with PEG-fDAO. The lung weight and pathological findings were significantly ameliorated by the administration of PEG-fDAO followed by intraperitoneal injection of D-phenylalanine or D-proline. These data suggest that PEG- fDAO with the function of targeted delivery to the nCA-induced inflammation site is applicable in the treatment of inflammation in CGD in vivo.

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