An atomic force microscopy approach for assessment of particle density applied to single spray-dried carbohydrate particles

2007 ◽  
Vol 96 (4) ◽  
pp. 905-912 ◽  
Author(s):  
Jessica Elversson ◽  
Karin Andersson ◽  
Anna Millqvist-Fureby
Keyword(s):  
Atomic Force Microscopy ◽  
Particle Density ◽  
Force Microscopy ◽  
Atomic Force ◽  
Spray Dried

scholarly journals An investigation of surface properties, local elastic modulus and interaction with simulated pulmonary surfactant of surface modified inhalable voriconazole dry powders using atomic force microscopy

RSC Advances ◽  
2016 ◽  
Vol 6 (31) ◽  
pp. 25789-25798 ◽  
Author(s):  
Sumit Arora ◽  
Michael Kappl ◽  
Mehra Haghi ◽  
Paul M. Young ◽  
Daniela Traini ◽  
...  
Keyword(s):  
Atomic Force Microscopy ◽  
Elastic Modulus ◽  
Surface Properties ◽  
Pulmonary Surfactant ◽  
Dry Powders ◽  
Force Microscopy ◽  
Atomic Force ◽  
Surface Modified ◽  
Spray Dried

l-Leucine modified voriconazole spray dried micropartcles.

Material Analysis by Ultrasonic Atomic Force Microscopy

2000 ◽  
Vol 627 ◽  
Author(s):  
Chiaki Miyasaka ◽  
Lily Jia ◽  
Bernhard R. Tittmann
Keyword(s):  
Atomic Force Microscopy ◽  
Surface Layer ◽  
Diagnostic Tool ◽  
Ceramic Powders ◽  
Detailed Structure ◽  
Force Microscopy ◽  
Nano Indentation ◽  
Atomic Force ◽  
Good Contrast ◽  
Spray Dried

ABSTRACTSpray-dried ceramic powders (e.g., Al2O3) are composed of a plurality of granules, each of which, includes ceramic particles and organic binders. It is assumed that the binders become concentrated in the surface layer of the granule in accordance with its type or its volume mixed into a ceramic portion of the granule. However, evidence to prove the assumption was limited because conventional microscopes were not able to clearly visualize the segregation. This paper presents a technique for imaging detailed structure of the spray-dried ceramic powders with the ultrasonic-atomic force microscope (U-AFM). The distribution of binder vis-a-vis Al2O3 particles is highly resolved with good contrast. The distribution was confirmed by nano -indentation. Thus, the U-AFM is shown to be a useful diagnostic tool for the development of approaches to spray-dried process evaluation.

Analysis of organic binder distribution in spray-dried granules by ultrasonic-atomic force microscopy

1999 ◽  
Author(s):  
Lili Jia ◽  
Michael Mandanas ◽  
Chiaki Miyasaka ◽  
Bernhard R. Tittmann ◽  
Gary L. Messing
Keyword(s):  
Atomic Force Microscopy ◽  
Organic Binder ◽  
Force Microscopy ◽  
Atomic Force ◽  
Spray Dried
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