A Process Analytical Technology approach to near-infrared process control of pharmaceutical powder blending: Part II: Qualitative near-infrared models for prediction of blend homogeneity

2006 ◽  
Vol 95 (2) ◽  
pp. 407-421 ◽  
Author(s):  
Arwa S. El-Hagrasy ◽  
Miriam Delgado-Lopez ◽  
James K. Drennen
Keyword(s):  
Process Control ◽  
Near Infrared ◽  
Process Analytical Technology ◽  
Powder Blending ◽  
Pharmaceutical Powder ◽  
Analytical Technology

scholarly journals Process analytical technology tools for process control of roller compaction in solid pharmaceuticals manufacturing

2020 ◽  
Vol 70 (4) ◽  
pp. 443-463 ◽  
Author(s):  
Aleša Dular Vovko ◽  
Franc Vrečer
Keyword(s):  
Infrared Spectroscopy ◽  
Process Control ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Process Analytical Technology ◽  
Imaging Techniques ◽  
Thermal Effusivity ◽  
Chemical Imaging ◽  
Roller Compaction ◽  
Analytical Technology

AbstractThis article presents an overview of using process analytical technology in monitoring the roller compaction process. In the past two decades, near-infrared spectroscopy, near-infrared spectroscopy coupled with chemical imaging, microwave resonance technology, thermal effusivity and various particle imaging techniques have been used for developing at-, off-, on- and in-line models for predicting critical quality attributes of ribbons and subsequent granules and tablets. The common goal of all these methods is improved process understanding and process control, and thus improved production of high-quality products. This article reviews the work of several researchers in this field, comparing and critically evaluating their achievements.

Potential of Near-Infrared Chemical Imaging as Process Analytical Technology Tool for Continuous Freeze-Drying

2018 ◽  
Vol 90 (7) ◽  
pp. 4354-4362 ◽  
Author(s):  
Davinia Brouckaert ◽  
Laurens De Meyer ◽  
Brecht Vanbillemont ◽  
Pieter-Jan Van Bockstal ◽  
Joris Lammens ◽  
...  
Keyword(s):  
Freeze Drying ◽  
Near Infrared ◽  
Process Analytical Technology ◽  
Chemical Imaging ◽  
Technology Tool ◽  
Analytical Technology
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