Near infrared and Raman spectroscopy as Process Analytical Technology tools for the manufacturing of silicone-based drug reservoirs

2011 ◽  
Vol 699 (1) ◽  
pp. 96-106 ◽  
Author(s):  
J. Mantanus ◽  
E. Rozet ◽  
K. Van Butsele ◽  
C. De Bleye ◽  
A. Ceccato ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Near Infrared ◽  
Process Analytical Technology ◽  
Technology Tools ◽  
Infrared And Raman Spectroscopy ◽  
Analytical Technology

Sample Mass Estimate for the Use of Near-Infrared and Raman Spectroscopy to Monitor Content Uniformity in a Tablet Press Feed Frame of a Drug Product Continuous Manufacturing Process

2020 ◽  
pp. 000370282095031
Author(s):  
Evan M. Hetrick ◽  
Zhenqi Shi ◽  
Zachary D. Harms ◽  
David P. Myers
Keyword(s):  
Raman Spectroscopy ◽  
Manufacturing Process ◽  
Near Infrared ◽  
Process Analytical Technology ◽  
Oral Dosage ◽  
Content Uniformity ◽  
Continuous Manufacturing ◽  
Sample Mass ◽  
Wide Range ◽  
Infrared And Raman Spectroscopy

Recently, feed frame-based process analytical technology measurements used to assure product quality during continuous manufacturing processes have received significant attention. These measurements are able to accurately determine uniformity of the powder blend before compression, and in these applications, it is necessary to understand the interrogated sample volume per measurement. This understanding ensures that the blend measurement can be indicative of the uniformity of the final dosage form. A scientifically sound approach is proposed here to estimate sample mass for a continuous manufacturing process that utilizes either near infrared or Raman spectroscopy. A wide range of commercially available probes with varying spot diameters are considered. By comparing near infrared and Raman spectroscopy, an optimal range of probe spot diameters was identified in order to reach an estimated sample mass between 50 and 500 mg for pharmaceutical blends per measurement, which is equivalent to common tablet weight ranges for solid oral dosage forms currently on the market.

Potential of Near-Infrared Chemical Imaging as Process Analytical Technology Tool for Continuous Freeze-Drying

2018 ◽  
Vol 90 (7) ◽  
pp. 4354-4362 ◽  
Author(s):  
Davinia Brouckaert ◽  
Laurens De Meyer ◽  
Brecht Vanbillemont ◽  
Pieter-Jan Van Bockstal ◽  
Joris Lammens ◽  
...  
Keyword(s):  
Freeze Drying ◽  
Near Infrared ◽  
Process Analytical Technology ◽  
Chemical Imaging ◽  
Technology Tool ◽  
Analytical Technology

Raman spectroscopy as a process analytical technology for cell therapy bioprocessing

Cytotherapy ◽  
2018 ◽  
Vol 20 (5) ◽  
pp. S105
Author(s):  
M. Baradez ◽  
D. Biziato ◽  
E. Hassan ◽  
D. Marshall
Keyword(s):  
Raman Spectroscopy ◽  
Cell Therapy ◽  
Process Analytical Technology ◽  
Analytical Technology
Sign in / Sign up

Export Citation Format

Share Document