Hepatic extraction, metabolism, and biliary excretion of irinotecan in the isolated perfused rat liver

2001 ◽  
Vol 90 (6) ◽  
pp. 722-731 ◽  
Author(s):  
Christian Farabos ◽  
Marie‐Christine Haaz ◽  
Pierre Gires ◽  
Jacques Robert
Keyword(s):  
Rat Liver ◽  
Biliary Excretion ◽  
Isolated Perfused Rat Liver ◽  
Perfused Rat Liver ◽  
Hepatic Extraction

Malaria infection impairs glucuronidation and biliary excretion by the isolated perfused rat liver

Xenobiotica ◽  
1991 ◽  
Vol 21 (12) ◽  
pp. 1571-1582 ◽  
Author(s):  
R. T. Murdoch ◽  
H. Ghabrial ◽  
G. W. Mihaly ◽  
D. J. Morgan ◽  
R. A. Smallwood
Keyword(s):  
Rat Liver ◽  
Biliary Excretion ◽  
Malaria Infection ◽  
Isolated Perfused Rat Liver ◽  
Perfused Rat Liver

Metabolism and biliary excretion of trimetrexate by the isolated perfused rat liver

1985 ◽  
Vol 29 (1) ◽  
pp. 65-71 ◽  
Author(s):  
Lorraine K. Webster ◽  
William P. Tong ◽  
John J. McCormack
Keyword(s):  
Rat Liver ◽  
Biliary Excretion ◽  
Isolated Perfused Rat Liver ◽  
Perfused Rat Liver

Biliary excretion of dihydro-11-keto-progesterone-4-C14 by isolated perfused liver

1964 ◽  
Vol 207 (5) ◽  
pp. 1030-1034 ◽  
Author(s):  
G. F. Leong ◽  
D. M. Cazes ◽  
M. L. Berliner ◽  
D. L. Berliner
Keyword(s):  
Rat Liver ◽  
Biliary Excretion ◽  
Half Life ◽  
Water Soluble ◽  
Isolated Perfused Rat Liver ◽  
Perfused Liver ◽  
Rapid Rate ◽  
Perfused Rat Liver ◽  
Bile Formation ◽  
Entire Study

The rates of biliary excretion of dihydro-11-keto-progesterone-4-C14 and of its metabolites were studied in the isolated perfused rat liver. The half-life of this steroid in the perfusing blood was 2.5 min, and at 40 min about 75% of the injected steroid had been excreted in bile. Formation of water-soluble steroids (WS St) took place at a rapid rate and by 60 min 100% of the steroids in blood were found to be water soluble. During the entire study the steroids excreted in bile were water soluble and accounted for 97.2–100% (avg. 98.2%). No dihydro-11-keto-progesterone was found to be excreted in the bile. The rate of disappearance from the blood, excretion in the bile, and degree of formation of WS St of this compound when compared with corticosterone and cortisol shows the following pattern: dihydro-11-keto-progesterone > corticosterone > cortisol.

Effect of Atropine on Bile Flow and Biliary Excretion of 3H-Ouabain in the Isolated Perfused Rat Liver

Pharmacology ◽  
1977 ◽  
Vol 15 (1) ◽  
pp. 57-64 ◽  
Author(s):  
Kaisu Nevasaari ◽  
Birgitta Alakare ◽  
Niilo T. Kärki
Keyword(s):  
Rat Liver ◽  
Biliary Excretion ◽  
Bile Flow ◽  
Isolated Perfused Rat Liver ◽  
Perfused Rat Liver

Biliary Excretion of Apolipoprotein B by the Isolated Perfused Rat Liver

1987 ◽  
Vol 92 (5) ◽  
pp. 1236-1242 ◽  
Author(s):  
Toshio Kawamoto ◽  
Simon J.T. Mao ◽  
Nicholas F. Larusso
Keyword(s):  
Rat Liver ◽  
Biliary Excretion ◽  
Apolipoprotein B ◽  
Isolated Perfused Rat Liver ◽  
Perfused Rat Liver

scholarly journals Studies on the Excretion of 3H-Heparin

1977 ◽  
Author(s):  
R. Losito ◽  
E. Lemieux ◽  
B. Longpré
Keyword(s):  
Rat Liver ◽  
Biliary Excretion ◽  
Intact Animal ◽  
Biliary Fistula ◽  
Isolated Perfused Rat Liver ◽  
Perfused Rat Liver ◽  
Biological Actions

Disappearance of heparin is still not well understood;because of this, we studied the excretion of 3H-heparin in (a) rats with biliary fistula and cystotomy, (b) rats with cystotomy, (c) hepatectomized rats and (d) in the isolated perfused rat liver. During 5 hours of perfusion, there was never more than 8% of the % excreted into the bile;most of the radioactivity (80%) remained in the blood. In bile, one radioactive component, which possessed slight anticoagulant and metachromatic activity was found and appears to be similar to heparin on chromatography and microelectrophoresis. In the intact animal, utilizing similar doses, the biliary excretion was similar to that of the isolated system;in contrast to the isolated system, radioactivity was quickly removed from the blood (over 90% in 5 h) and excreted into the urine (30% and 60% after 5 h and 10 h respectively). In hepatectomized animals, it was observed that only 15% of heparin radioactivity could be excreted in 24 hours. Hence it is postulated that the liver appears to have an important role to plav in the metabolism and biological actions of heparin since (1) it removes 3n_heparin from blood and excretes it into the bile and (2) the results of the hepatectomized experiments showing that only one-fifth the heparin was excreted compared to the control rats without hepatectomy.

scholarly journals Papaverine inhibits biliary excretion of lipids independently of effects on bile salts secretion in isolated perfused rat liver.

Kanzo ◽  
1990 ◽  
Vol 31 (11) ◽  
pp. 1359-1360
Author(s):  
T HAYAKAWA ◽  
K KATAGIRI ◽  
T KUMAI ◽  
T OHIWA ◽  
T NAKAI ◽  
...  
Keyword(s):  
Rat Liver ◽  
Biliary Excretion ◽  
Bile Salts ◽  
Isolated Perfused Rat Liver ◽  
Perfused Rat Liver
Sign in / Sign up

Export Citation Format

Share Document