Progressive Loss of Implant Fixation in a Preclinical Rat Model of Cemented Knee Arthroplasty

2020 ◽  
Author(s):  
Kenneth A Mann ◽  
Mark A Miller ◽  
Jeffrey K Rossow ◽  
Megan E Tatusko ◽  
Jason A Horton ◽  
...  
Keyword(s):  
Knee Arthroplasty ◽  
Rat Model ◽  
Implant Fixation ◽  
Progressive Loss

scholarly journals Cumulative mtDNA damage and mutations contribute to the progressive loss of RGCs in a rat model of glaucoma

2015 ◽  
Vol 74 ◽  
pp. 167-179 ◽  
Author(s):  
Ji-hong Wu ◽  
Sheng-hai Zhang ◽  
John M. Nickerson ◽  
Feng-juan Gao ◽  
Zhongmou Sun ◽  
...  
Keyword(s):  
Rat Model ◽  
Mtdna Damage ◽  
Progressive Loss

The Use of Stems for Morbid Obesity in Total Knee Arthroplasty

2019 ◽  
Vol 32 (07) ◽  
pp. 607-610 ◽  
Author(s):  
Blake J. Schultz ◽  
Malcolm R. DeBaun ◽  
James I. Huddleston
Keyword(s):  
Total Knee Arthroplasty ◽  
Knee Arthroplasty ◽  
High Risk Patient ◽  
Morbidly Obese ◽  
Obese Patients ◽  
Limited Data ◽  
Implant Fixation ◽  
Knee Motion ◽  
Total Knee ◽  
Nonobese Patients

AbstractMorbidly obese patients undergoing total knee arthroplasty have worse functional outcomes and implant survival, and increased revision rates compared with nonobese patients. In addition to increased medical comorbidities and difficult exposure, increased stress on the tibial implant and altered kinematics of knee motion contribute to aseptic loosening and medial collapse. Increased implant fixation, including use of a stemmed tibial implant, may be a way to help avoid these complications. While there is limited data on tibial stems in the morbidly obese patients specifically, cemented stemmed tibial implants should be strongly considered in these patients, especially if bone quality is poor. The initial increased cost of a stemmed implant can be justified in this high-risk patient population to minimize the risk of costly revisions related to compromised tibia component fixation.

scholarly journals Total Knee Arthroplasty with a Ti6Al4V/PEEK Prosthesis on an Osteoarthritis Rat Model: Behavioral and Neurophysiological Analysis

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Mathieu Lecocq ◽  
Jean-Marc Linares ◽  
Julien Chaves-Jacob ◽  
Thelma Coyle ◽  
Sandrine Roffino ◽  
...  
Keyword(s):  
Total Knee Arthroplasty ◽  
Knee Arthroplasty ◽  
Rat Model ◽  
Total Knee

scholarly journals Novel AAV-Based Rat Model of Forebrain Synucleinopathy Shows Extensive Pathologies and Progressive Loss of Cholinergic Interneurons

PLoS ONE ◽  
2014 ◽  
Vol 9 (7) ◽  
pp. e100869 ◽  
Author(s):  
Patrick Aldrin-Kirk ◽  
Marcus Davidsson ◽  
Staffan Holmqvist ◽  
Jia-Yi Li ◽  
Tomas Björklund
Keyword(s):  
Rat Model ◽  
Cholinergic Interneurons ◽  
Progressive Loss

Intra-articular vancomycin for the prophylaxis of periprosthetic joint infection caused by methicillin-resistant S. aureus after total knee arthroplasty in a rat model: the dosage, efficacy, and safety

2021 ◽  
Author(s):  
Jian Wei ◽  
Kai Tong ◽  
Hui Wang ◽  
Yinxian Wen ◽  
Liaobin Chen
Keyword(s):  
Total Knee Arthroplasty ◽  
Knee Arthroplasty ◽  
Rat Model ◽  
Periprosthetic Joint Infection ◽  
Joint Infection ◽  
Efficacy And Safety ◽  
Methicillin Resistant ◽  
Tissue Inflammation ◽  
Vancomycin Powder ◽  
Total Knee

Although intra-articular vancomycin powder (VP) is sometimes applied before the closure of the incision to prevent periprosthetic joint infection (PJI) after joint replacement, the dosage, efficacy and safety remain controversial. This study aimed to explore the dosage, efficacy, and safety of intra-articular VP in the prophylaxis of infection after total knee arthroplasty (TKA) in a rat model. Sixty male rats were randomly divided into five groups after receiving TKA surgery: Control (no antibiotics); systemic vancomycin (SV) (intraperitoneal injection, 88 mg/kg, equal to 1g in a patient weighted 70kg); VP0.5, VP1.0 and VP2.0 (44 mg/kg, 88 mg/kg and 176 mg/kg respectively, intra-articular). All animals were inoculated in the knee with methicillin-resistant S. aureus (MRSA). General status, serum biomarkers, radiology, microbiological assay and histopathological tests were assessed within 14 days post-operatively. Compared with the Control and SV groups, bacterial counts, knee-width, tissue inflammation, and osteolysis were reduced in the VP0.5, VP1.0 and VP2.0 groups, without notable bodyweight loss and incision complications. Among all the VP groups, VP1.0 and VP2.0 groups presented superior outcomes in the knee-width and tissue inflammation than the VP0.5 group. Microbial culture indicated that no MRSA survived in the knee of VP1.0 and VP2.0 groups, while bacteria growth was observed in VP0.5 group. No obvious changes in the structure and functional biomarkers of liver and kidney were observed in both SV and VP groups. Therefore, intra-articular vancomycin powder at the dosage from 88 mg/kg to 176 mg/kg may be effective and safe in preventing PJI induced by methicillin-resistant S. aureus in the rat TKA model.

Response to Letter to the Editor on “Tibial implant Fixation Behavior in Total Knee Arthroplasty – A Study With Five Different Types of Bone Cements”

2021 ◽  
Vol 36 (5) ◽  
pp. e32-e33
Author(s):  
Thomas M. Grupp ◽  
Christoph Schilling ◽  
Jens Schwiesau ◽  
Andreas Pfaff ◽  
Brigitte Altermann ◽  
...  
Keyword(s):  
Total Knee Arthroplasty ◽  
Knee Arthroplasty ◽  
Bone Cements ◽  
Implant Fixation ◽  
Letter To The Editor ◽  
Different Types ◽  
Total Knee

scholarly journals Early changes in serum osteocalcin and body weight are predictive of implant fixation in a rat model of implant loosening

2019 ◽  
Vol 38 (6) ◽  
pp. 1216-1227 ◽  
Author(s):  
Brittany M. Wilson ◽  
Meghan M. Moran ◽  
Matthew J. Meagher ◽  
Ryan D. Ross ◽  
Maleeha Mashiatulla ◽  
...  
Keyword(s):  
Body Weight ◽  
Rat Model ◽  
Serum Osteocalcin ◽  
Implant Loosening ◽  
Implant Fixation

scholarly journals Tibial Implant Fixation Behavior in Total Knee Arthroplasty: A Study With Five Different Bone Cements

2020 ◽  
Vol 35 (2) ◽  
pp. 579-587
Author(s):  
Thomas M. Grupp ◽  
Christoph Schilling ◽  
Jens Schwiesau ◽  
Andreas Pfaff ◽  
Brigitte Altermann ◽  
...  
Keyword(s):  
Total Knee Arthroplasty ◽  
Knee Arthroplasty ◽  
Bone Cements ◽  
Implant Fixation ◽  
Total Knee

scholarly journals Wear Assessment of Tibial Inserts Made of Highly Cross-Linked Polyethylene Supplemented with Dodecyl Gallate in the Total Knee Arthroplasty

Polymers ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 1847
Author(s):  
Min Zhang ◽  
Jia-Yu Wang ◽  
Jian Su ◽  
Jian-Jun Wang ◽  
Shi-Tong Yan ◽  
...  
Keyword(s):  
Total Knee Arthroplasty ◽  
Wear Rate ◽  
Knee Arthroplasty ◽  
Calf Serum ◽  
Oxidation Stability ◽  
Wear Particles ◽  
Implant Fixation ◽  
Dodecyl Gallate ◽  
Tibial Insert ◽  
Total Knee

Background: the wear of tibial insert is still one of primary factors leading to failure of total knee arthroplasty (TKA). Dodecyl gallate (DG) has shown improvements in the oxidation stability of highly cross-linked polyethylene (HXLPE). This study aimed to assess the application of HXLPE supplemented with DG (HXLPE-DG) on the tibial insert in TKA concerning the wear resistance and the potential impact on implant fixation; Methods: tibial inserts made of HXLPE-DG were subjected to a 3 million loading-cycle wear test following ISO 14243-1:2009. The loss of mass and wear rate of the tibial inserts were calculated. The quantity, size,- and shape of wear particles were recorded; Results: the test specimens lost an average mass of 16.00 mg ± 0.94 mg, and were on an average wear rate of 3.92 mg/million cycles ± 0.19 mg/million cycles. The content of wear particles in the calf serum medium was 3.94 × 108 particles/mL ± 3.93 × 107 particles/mL, 96.66% ± 0.77% of the particles had an equivalent circular diameter less than 0.5 μm. The aspect ratio of wear particles was 1.40 (min: 1.01; max: 6.42). Conclusions: HXLPE-DG displayed advantages over the commonly used materials for tibial inserts and presented the potential of application in TKA.

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