scholarly journals Feasibility of a self‐assembling peptide hydrogel scaffold for meniscal defect: An in vivo study in a rabbit model

2020 ◽  
Vol 39 (1) ◽  
pp. 165-176
Author(s):  
Nobuhiro Okuno ◽  
Shuhei Otsuki ◽  
Jo Aoyama ◽  
Kosuke Nakagawa ◽  
Tomohiko Murakami ◽  
...  
Keyword(s):  
Rabbit Model ◽  
In Vivo Study ◽  
Hydrogel Scaffold ◽  
Self Assembling ◽  
Peptide Hydrogel

scholarly journals Trypsin Pre‐Treatment Combined With Growth Factor Functionalized Self‐Assembling Peptide Hydrogel Improves Cartilage Repair in Rabbit Model

2019 ◽  
Vol 37 (11) ◽  
pp. 2307-2315 ◽  
Author(s):  
Gustavo Zanotto ◽  
Paul Liebesny ◽  
Myra Barrett ◽  
Hannah Zlotnick ◽  
Alan Grodzinsky ◽  
...  
Keyword(s):  
Growth Factor ◽  
Cartilage Repair ◽  
Rabbit Model ◽  
Self Assembling ◽  
Pre Treatment ◽  
Peptide Hydrogel

scholarly journals Investigating the In Vivo Antimicrobial Activity of a Self-Assembling Peptide Hydrogel Using a Galleria mellonella Infection Model

ACS Omega ◽  
2019 ◽  
Vol 4 (2) ◽  
pp. 2584-2589 ◽  
Author(s):  
Alice P. McCloskey ◽  
Merissa Lee ◽  
Julianne Megaw ◽  
Judith McEvoy ◽  
Sophie M. Coulter ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Galleria Mellonella ◽  
Infection Model ◽  
Self Assembling ◽  
Peptide Hydrogel

scholarly journals Rabbit model for in vivo study of anthracycline-induced heart failure and for the evaluation of protective agents

2004 ◽  
Vol 6 (4) ◽  
pp. 377-387 ◽  
Author(s):  
Tomáš Šimůnek ◽  
Ivona Klimtová ◽  
Jana Kaplanová ◽  
Yvona Mazurová ◽  
Michaela Adamcová ◽  
...  
Keyword(s):  
Heart Failure ◽  
Rabbit Model ◽  
In Vivo Study ◽  
Protective Agents

scholarly journals Rabbit Model for in vivo Study of Intervertebral Disc Degeneration and Regeneration

2008 ◽  
Vol 44 (5) ◽  
pp. 327 ◽  
Author(s):  
Min Ho Kong ◽  
Duc H. Do ◽  
Masashi Miyazaki ◽  
Feng Wei ◽  
Sung-Hwan Yoon ◽  
...  
Keyword(s):  
Intervertebral Disc ◽  
Disc Degeneration ◽  
Intervertebral Disc Degeneration ◽  
Rabbit Model ◽  
In Vivo Study

Targeted Chemotherapy for Breast Cancer Using an Intelligent Doxorubicin-Loaded Hexapeptide Hydrogel

2020 ◽  
Vol 16 (6) ◽  
pp. 842-852
Author(s):  
Shiyao Luo ◽  
Ying Zhu ◽  
Yiping Li ◽  
Li Chen ◽  
Shunzhong Lv ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Solid Phase ◽  
Synthesis Method ◽  
High Water ◽  
High Water Content ◽  
Normal Tissues ◽  
Self Assembling ◽  
Peptide Hydrogel

Self-assembling peptide hydrogels have a high water content, good biocompatibility and have become a competitive research object in the fields of tissue engineering, cancer treatment and drug delivery. In our research, a hexapeptide with high pH sensitivity was designed and synthesized by utilizing a solid-phase synthesis method. Under physiological conditions, the peptide could self-assemble into a hydrogel. When it reached the tumor acidic microenvironment, the peptide was degraded and doxorubicin was released to exert its antitumor effect. A series of physicochemical properties were investigated, including gelling ability, secondary structure, micromorphology, rheological properties and drug release studies. The results illustrated that PIDO peptide hydrogel has good pH responsiveness and injectability. In vitro cytotoxicity experiments and in vivo antitumor experiments showed that PIDO peptide hydrogel has a highly effective therapeutic effect on tumor cells and is less toxic to normal tissues. Our research provides a promising option for targeted drug delivery and sustainable release.

MRI-Guided Radiofrequency Thermal Ablation of Normal Lung Tissue: In Vivo Study in a Rabbit Model

2004 ◽  
Vol 183 (3) ◽  
pp. 599-603 ◽  
Author(s):  
Frank K. Wacker ◽  
Sherif G. Nour ◽  
Rosana Eisenberg ◽  
Jeffrey L. Duerk ◽  
Jonathan S. Lewin
Keyword(s):  
Lung Tissue ◽  
Thermal Ablation ◽  
Rabbit Model ◽  
In Vivo Study ◽  
Normal Lung Tissue ◽  
Normal Lung ◽  
Radiofrequency Thermal Ablation ◽  
Mri Guided
Sign in / Sign up

Export Citation Format

Share Document