scholarly journals Evaluation of human cartilage endplate composition using MRI: Spatial variation, association with adjacent disc degeneration, and in vivo repeatability

2020 ◽  
Author(s):  
Linshanshan Wang ◽  
Misung Han ◽  
Jason Wong ◽  
Patricia Zheng ◽  
Ann A. Lazar ◽  
...  
Keyword(s):  
Spatial Variation ◽  
Disc Degeneration ◽  
Human Cartilage ◽  
Cartilage Endplate ◽  
Adjacent Disc

scholarly journals Cartilage Endplate Thickness Variation Measured by Ultrashort Echo-Time MRI Is Associated With Adjacent Disc Degeneration

Spine ◽  
2018 ◽  
Vol 43 (10) ◽  
pp. E592-E600 ◽  
Author(s):  
Britta Berg-Johansen ◽  
Misung Han ◽  
Aaron J. Fields ◽  
Ellen C. Liebenberg ◽  
Brandon J. Lim ◽  
...  
Keyword(s):  
Disc Degeneration ◽  
Thickness Variation ◽  
Ultrashort Echo Time ◽  
Cartilage Endplate ◽  
Adjacent Disc ◽  
Echo Time

Immortalization of Human Cartilage Endplate Stem Cell from Degenerated Human Intervertebral Disc

2014 ◽  
Vol 4 (1_suppl) ◽  
pp. s-0034-1376589-s-0034-1376589
Author(s):  
M. Liu ◽  
B. Huang ◽  
Y. Zhou
Keyword(s):  
Stem Cell ◽  
Intervertebral Disc ◽  
Human Cartilage ◽  
Cartilage Endplate

scholarly journals An in vivo study of the effect of c-Jun on intervertebral disc degeneration in rats

Bioengineered ◽  
2021 ◽  
Vol 12 (1) ◽  
pp. 4320-4330
Author(s):  
Ming Lei ◽  
Kangcheng Zhao ◽  
Wenbin Hua ◽  
Kun Wang ◽  
Shuai Li ◽  
...  
Keyword(s):  
Intervertebral Disc ◽  
Disc Degeneration ◽  
Intervertebral Disc Degeneration ◽  
In Vivo Study

scholarly journals Injection of a polymerized hyaluronic acid/collagen hydrogel matrix in an in vivo porcine disc degeneration model

2012 ◽  
Vol 21 (9) ◽  
pp. 1700-1708 ◽  
Author(s):  
G. W. Omlor ◽  
A. G. Nerlich ◽  
H. Lorenz ◽  
T. Bruckner ◽  
W. Richter ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Disc Degeneration ◽  
Collagen Hydrogel ◽  
Hydrogel Matrix

scholarly journals In vitro and in vivo evaluation of discogenic cells, an investigational cell therapy for disc degeneration

2020 ◽  
Vol 20 (1) ◽  
pp. 138-149 ◽  
Author(s):  
Lara Ionescu Silverman ◽  
Galina Dulatova ◽  
Terry Tandeski ◽  
Isaac E. Erickson ◽  
Beverly Lundell ◽  
...  
Keyword(s):  
Cell Therapy ◽  
Disc Degeneration ◽  
In Vivo Evaluation

scholarly journals In vivo intervertebral disc deformation: intratissue strain patterns within adjacent discs during flexion–extension

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Robert L. Wilson ◽  
Leah Bowen ◽  
Woong Kim ◽  
Luyao Cai ◽  
Stephanie Ellyse Schneider ◽  
...  
Keyword(s):  
Intervertebral Disc ◽  
Biomechanical Analysis ◽  
Resonance Imaging ◽  
Tissue Architecture ◽  
Mechanical Responses ◽  
Flexion Extension ◽  
Adjacent Disc ◽  
Shear Strains ◽  
Magnetic Resonance Imaging Mri

AbstractThe biomechanical function of the intervertebral disc (IVD) is a critical indicator of tissue health and pathology. The mechanical responses (displacements, strain) of the IVD to physiologic movement can be spatially complex and depend on tissue architecture, consisting of distinct compositional regions and integrity; however, IVD biomechanics are predominately uncharacterized in vivo. Here, we measured voxel-level displacement and strain patterns in adjacent IVDs in vivo by coupling magnetic resonance imaging (MRI) with cyclic motion of the cervical spine. Across adjacent disc segments, cervical flexion–extension of 10° resulted in first principal and maximum shear strains approaching 10%. Intratissue spatial analysis of the cervical IVDs, not possible with conventional techniques, revealed elevated maximum shear strains located in the posterior disc (nucleus pulposus) regions. IVD structure, based on relaxometric patterns of T2 and T1ρ images, did not correlate spatially with functional metrics of strain. Our approach enables a comprehensive IVD biomechanical analysis of voxel-level, intratissue strain patterns in adjacent discs in vivo, which are largely independent of MRI relaxometry. The spatial mapping of IVD biomechanics in vivo provides a functional assessment of adjacent IVDs in subjects, and provides foundational biomarkers for elastography, differentiation of disease state, and evaluation of treatment efficacy.

The biomechanical effects of S-type dynamic cage using Ti and PEEK for ACDF surgery on cervical spine varying loads

2021 ◽  
pp. 039139882110395
Author(s):  
Pechimuthu Susai Manickam ◽  
Sandipan Roy
Keyword(s):  
Disc Degeneration ◽  
Lower Risk ◽  
Mechanical Stability ◽  
Early Stage ◽  
Cervical Disc ◽  
Adjacent Segment ◽  
Stress Profile ◽  
Fe Model ◽  
Cage Subsidence ◽  
Adjacent Disc

Anterior cervical discectomy with fusion (ACDF) is the common method to treat the cervical disc degeneration. The most serious problems in the fusion cages are adjacent disc degeneration, loss of lordosis, pain, subsidence, and migration of the cage. The objective of our work is to develop the three-dimensional finite element (FE) model from C3-C6 and virtually implant a designed S-type dynamic cage at C4-C5 segment of the model. The dynamic cage design will provide mobility in the early stage after ACDF surgery. Titanium (Ti) and PEEK (polyether ether ketone) were used as the material property for the cages. We applied the physiological motions at different loads from 0.5, 1, 1.5, 2.0 Nm to evaluate the dynamic cage design and the biomechanical performances of the designed S-type dynamic cage. It was observed that in all the loading condition the range of motion in the adjacent level was maintained and the maximum stress at the adjacent disc was reduced. The clinical significance of the S-type dynamic cage is better stress profile at the fusion level and adjacent segments which translates into higher rate of fusion, lower risk of cage subsidence, lower risk of adjacent segment degeneration, and good mechanical stability.

Sign in / Sign up

Export Citation Format

Share Document