Assessing the biofidelity of in vitro biomechanical testing of the human cervical spine

2020 ◽  
Author(s):  
Richard A. Wawrose ◽  
Forbes E. Howington ◽  
Clarissa M. LeVasseur ◽  
Clair N. Smith ◽  
Brandon K. Couch ◽  
...  
Keyword(s):  
Cervical Spine ◽  
Biomechanical Testing

Cervical spine locking plate: in vitro biomechanical testing

1993 ◽  
Vol 1 (4) ◽  
pp. 222-225 ◽  
Author(s):  
Stephen A. Smith ◽  
Ronald W. Lindsey ◽  
Brian J. Doherty ◽  
Jerry W. Alexander ◽  
Jessie H. Dickson
Keyword(s):  
Cervical Spine ◽  
Locking Plate ◽  
Biomechanical Testing

Use of Spine Robot Employing Real Time Force Control to Simulate a Pure Moment Protocol for the Subaxial Cervical Spine: An In Vitro Biomechancial Study

2011 ◽  
Author(s):  
Daniel M. Wido ◽  
Denis J. DiAngelo ◽  
Brian P. Kelly
Keyword(s):  
Cervical Spine ◽  
Real Time ◽  
Force Control ◽  
Biomechanical Testing ◽  
Subaxial Cervical Spine ◽  
Experimental Artifact ◽  
Pure Moment ◽  
Robotic Testing ◽  
Spine Robot

A standard biomechanical testing protocol for evaluation of the sub-axial cervical spine is the application of pure bending moments to the free end of the spine (with opposing end fixed) and measurement of its motion response. The pure moment protocol is often used to compare spinal fusion instrumentation and has also been used to evaluate non-fusion instrumentation (e.g. disc arthroplasty devices) [1,2]. A variety of different testing systems have been employed to implement pure moment application. In cases where the loading is applied quasi-statically using a series of weights and pulleys the spine may relax between intermittent loading phases and/or unintended loading may be applied causing experimental artifact. Our objective was to use an existing programmable robotic testing platform (Spine Robot) to develop a novel real time force control strategy to simulate pure moment loading under precisely controlled continuous movement conditions. This would serve to advance robotic testing capabilities with an end goal to simulate different protocols in the same platform, and to potentially minimize fixturing and quasi-static artifacts.

In-Vitro Biomechanical Testing of the AO Cervical Spine Locking Plate

1993 ◽  
Vol 7 (2) ◽  
pp. 171
Author(s):  
Stephen A. Smith ◽  
Ronald W. Lindsey ◽  
Brian J. Doherty ◽  
Jerry W. Alexander ◽  
Jessie H. Dickson
Keyword(s):  
Cervical Spine ◽  
Locking Plate ◽  
Biomechanical Testing

IN VITRO BIOMECHANICAL TESTING OF THE CERVICAL SPINE LOCKING PLATE

1992 ◽  
Vol 85 (Supplement) ◽  
pp. 3S-58
Author(s):  
S. A. Smith ◽  
R. W. Lindsey ◽  
B. J. Doherty ◽  
J. W. Alexander ◽  
J. H. Dickson
Keyword(s):  
Cervical Spine ◽  
Locking Plate ◽  
Biomechanical Testing

scholarly journals Lumbar Interbody Fusion Conducted on a Porcine Model with a Bioresorbable Ceramic/Biopolymer Hybrid Implant Enriched with Hyperstable Fibroblast Growth Factor 2

Biomedicines ◽  
2021 ◽  
Vol 9 (7) ◽  
pp. 733
Author(s):  
Milan Krticka ◽  
Ladislav Planka ◽  
Lucy Vojtova ◽  
Vladimir Nekuda ◽  
Premysl Stastny ◽  
...  
Keyword(s):  
Growth Factor ◽  
Lumbar Fusion ◽  
Biomechanical Testing ◽  
Fibroblast Growth Factor 2 ◽  
Oxidized Cellulose ◽  
Fibroblast Growth ◽  
Micro Ct ◽  
Bone Autograft ◽  
Autograft Group

Many growth factors have been studied as additives accelerating lumbar fusion rates in different animal models. However, their low hydrolytic and thermal stability both in vitro and in vivo limits their workability and use. In the proposed work, a stabilized vasculogenic and prohealing fibroblast growth factor-2 (FGF2-STAB®) exhibiting a functional half-life in vitro at 37 °C more than 20 days was applied for lumbar fusion in combination with a bioresorbable scaffold on porcine models. An experimental animal study was designed to investigate the intervertebral fusion efficiency and safety of a bioresorbable ceramic/biopolymer hybrid implant enriched with FGF2-STAB® in comparison with a tricortical bone autograft used as a gold standard. Twenty-four experimental pigs underwent L2/3 discectomy with implantation of either the tricortical iliac crest bone autograft or the bioresorbable hybrid implant (BHI) followed by lateral intervertebral fixation. The quality of spinal fusion was assessed by micro-computed tomography (micro-CT), biomechanical testing, and histological examination at both 8 and 16 weeks after the surgery. While 8 weeks after implantation, micro-CT analysis demonstrated similar fusion quality in both groups, in contrast, spines with BHI involving inorganic hydroxyapatite and tricalcium phosphate along with organic collagen, oxidized cellulose, and FGF2- STAB® showed a significant increase in a fusion quality in comparison to the autograft group 16 weeks post-surgery (p = 0.023). Biomechanical testing revealed significantly higher stiffness of spines treated with the bioresorbable hybrid implant group compared to the autograft group (p < 0.05). Whilst histomorphological evaluation showed significant progression of new bone formation in the BHI group besides non-union and fibrocartilage tissue formed in the autograft group. Significant osteoinductive effects of BHI based on bioceramics, collagen, oxidized cellulose, and FGF2-STAB® could improve outcomes in spinal fusion surgery and bone tissue regeneration.

scholarly journals Comparative in vitro study and biomechanical testing of two different magnesium alloys

2013 ◽  
Vol 28 (8) ◽  
pp. 1264-1273 ◽  
Author(s):  
Andreas Weizbauer ◽  
Christian Modrejewski ◽  
Sabine Behrens ◽  
Helmut Klein ◽  
Patrick Helmecke ◽  
...  
Keyword(s):  
Magnesium Alloys ◽  
Biomechanical Testing ◽  
In Vitro Study ◽  
Vitro Study

In Vitro Biomechanical Testing of the Tube Knot

2016 ◽  
Vol 45 (7) ◽  
pp. 962-967 ◽  
Author(s):  
Stephany Chang ◽  
Fanglong Dong ◽  
Minette Lagman ◽  
Peggy L. Schmidt ◽  
Kristopher L. Irizarry ◽  
...  
Keyword(s):  
Biomechanical Testing

In Vitro Comparison of a Translational Anterior Cervical Plate With a Constrained Anterior Cervical Plate

2001 ◽  
Author(s):  
Denis J. DiAngelo ◽  
Weiqiang Liu ◽  
Kristine M. Olney ◽  
Kevin T. Foley
Keyword(s):  
Cervical Spine ◽  
Cervical Spondylosis ◽  
Load Transfer ◽  
Multi Level ◽  
Cervical Plate ◽  
Degenerative Disorder ◽  
Anterior Cervical Plate ◽  
Cervical Plating ◽  
In Vitro Comparison

Abstract Cervical spondylosis is the most common degenerative disorder affecting the cervical spine and is often treated surgically to prevent further neurological deterioration. However, clinical experience has shown that anterior cervical plating does not prevent construct failure in multi-level cervical corpectomy (Vaccaro et al., 1998). We have previously shown that anterior cervical plating reverses the load transfer through multi-level strut-grafts and may promote pistoning of these grafts (DiAngelo et al., 2000). The design of the anterior cervical plate (ACP) may contribute to this phenomenon. The purpose of this study was to compare the graft loading mechanics of two different anterior cervical plating systems; one with a constrained plate-screw interface versus another with a semi-constrained, translational plate-screw interface.

scholarly journals Biomechanical Effects of Tibial Plateau Levelling Osteotomy on Joint Instability in Normal Canine Stifles: An In Vitro Study

2020 ◽  
Vol 33 (05) ◽  
pp. 301-307
Author(s):  
Masakazu Shimada ◽  
Tetsuya Takagi ◽  
Nobuo Kanno ◽  
Satoshi Yamakawa ◽  
Hiromichi Fujie ◽  
...  
Keyword(s):  
Joint Instability ◽  
Tibial Plateau ◽  
Cruciate Ligament ◽  
Biomechanical Testing ◽  
In Vitro Study ◽  
Axial Rotation ◽  
Testing System ◽  
Compression Tests ◽  
Cranial Cruciate Ligament

Abstract Objective The aim of the study was to determine the changes in biomechanical characteristics following tibial plateau levelling osteotomy (TPLO) using simulated manual tests. Study Design Twenty-one stifles from healthy Beagle dogs that had undergone TPLO or had not (control) were first tested in the intact form, and then the cranial cruciate ligament (CrCL) was transected in each to provide four test situations: control-intact, control-CrCL-transected, TPLO-intact and TPLO-CrCL-transected. The stifles were then analysed using a robotic joint biomechanical testing system. The craniocaudal drawer, axial rotation and proximal compression tests were applied. Results The craniocaudal displacement during the drawer test was not significantly different between the control-intact and TPLO-intact. However, the displacement was significantly greater in the TPLO-CrCL-transected than in the control-intact. In the axial rotation test, the internal–external (IE) rotation was significantly greater in the TPLO-intact than in the control-intact. Similarly, the IE rotation was significantly greater in the TPLO-CrCL-transected than in the control-CrCL-transected. In the proximal compression test, craniocaudal displacement was not significantly different among the control-intact, TPLO-intact and TPLO-CrCL-transected. Conclusion These findings suggest that TPLO influences the tension of the collateral ligaments and might generate laxity of the tibiofemoral joint. Instability after the osteotomy might be associated with the progression of osteoarthritis.

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