scholarly journals Association between subchondral bone structure and osteoarthritis histopathological grade

2016 ◽  
Vol 35 (4) ◽  
pp. 785-792 ◽  
Author(s):  
Mikko A. J. Finnilä ◽  
Jérôme Thevenot ◽  
Olli-Matti Aho ◽  
Virpi Tiitu ◽  
Jari Rautiainen ◽  
...  
Keyword(s):  
Subchondral Bone ◽  
Bone Structure ◽  
Histopathological Grade

scholarly journals Evaluation of human subchondral bone structure using volumetric local binary patterns method

2014 ◽  
Vol 22 ◽  
pp. S349
Author(s):  
J. Thevenot ◽  
M. Finnilä ◽  
O-M. Aho ◽  
V. Tiitu ◽  
J. Rautiainen ◽  
...  
Keyword(s):  
Subchondral Bone ◽  
Bone Structure ◽  
Local Binary Patterns

scholarly journals DEVELOPING THE COMMON MARMOSET AS A TRANSLATIONAL MODEL OF AGE-RELATED OSTEOARTHRITIS

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S104-S104
Author(s):  
Dennis M Minton ◽  
Angela J Marolf ◽  
Kelly S Santangelo ◽  
Adam B Salmon ◽  
Adam R Konopka
Keyword(s):  
Subchondral Bone ◽  
Bone Structure ◽  
Common Marmoset ◽  
Knee Joints ◽  
Micro Computed Tomography ◽  
Bone Thickness ◽  
Aging Research ◽  
Naturally Occurring ◽  
Age Related ◽  
The Common

Abstract Age is a primary risk factor for osteoarthritis (OA). The mechanisms that contribute to OA are poorly understood and disease modifying treatments have not been identified. A critical shortcoming in developing therapies is the limited number of translational models available to identify the causes of naturally occurring OA. Our goal is to use the common marmoset as a non-human primate (NHP) model of age-related OA. NHP are the closest evolutionary relative to humans and share many characteristics of human aging. The marmoset has advantages over other NHP for aging research because of their relatively short maximal lifespan and small size. Micro-computed tomography (uCT) was performed on whole-knee joints obtained from young (10 yrs, n=3) marmosets at necropsy. OA was evaluated using a clinical uCT scoring system and quantitative assessments of subchondral bone structure and ossified meniscal volume. Advancing age was positively correlated to increased uCT OA score (p<0.05, r=0.59 ), mainly through increased number and size of osteophytes and progressive subchondral bone sclerosis from the medial to both medial and lateral compartments. For marmosets displaying meniscal ossification, older marmosets had greater (p<0.05) ossified meniscal volume than middle-aged and younger marmosets, respectively. Trabecular (p=0.05) and cortical bone thickness (p<0.05) were also lower in older marmosets. These data are the first to indicate that the marmoset develops naturally occurring, age-related OA and support the pursuit of additional studies using the marmoset to identify OA mechanisms and test potential interventions.

Doxycycline effects on mechanical and morphometrical properties of early- and late-stage osteoarthritic bone following anterior cruciate ligament injury

2004 ◽  
Vol 97 (4) ◽  
pp. 1254-1260 ◽  
Author(s):  
Connor K. Pardy ◽  
John R. Matyas ◽  
Ronald F. Zernicke
Keyword(s):  
Anterior Cruciate Ligament ◽  
Bone Loss ◽  
Trabecular Bone ◽  
Subchondral Bone ◽  
Bone Structure ◽  
Femoral Condyle ◽  
Cruciate Ligament ◽  
Ligament Injury ◽  
Doxycycline Treatment ◽  
Anterior Cruciate

As posttraumatic osteoarthritis (OA) progresses, the mechanical and morphometrical properties of the subchondral bone change and may be linked to damage of the articular cartilage. Potentially to slow that progression, doxycycline was administered orally twice daily (4 mg·kg−1·day−1) in skeletally mature canines after anterior cruciate ligament transection (ACLX). To test if doxycycline significantly altered the structure and function of OA bone, we tested cancellous bone mechanical properties, measured bone mineral content, and analyzed bone structure by microcomputed tomography. Our investigation focused on subchondral trabecular bone changes in the medial femoral condyle at 36 and 72 wk after ACLX. Significant mechanical changes discovered at 36 wk post-ACLX were less obvious at 72 wk in both treated and ACLX groups. Doxycycline treatment conserved bone strain energy density at 72 wk. Doxycycline had little effect on the degradation of superficial osseous tissue at 36 wk post-ACLX; by 72 wk, doxycycline in an ACLX model limited subchondral bone loss within the first 3 mm of periarticular bone with established OA. Significant bone loss occurred in the deeper trabecular bone for all groups. Substantial architectural adaptation within deeper trabecular bone accompanied changes in mechanics in early and established OA.

scholarly journals Similarities and discrepancies in subchondral bone structure in two differently induced canine models of osteoarthritis

2010 ◽  
Vol 25 (7) ◽  
pp. 1650-1657 ◽  
Author(s):  
Femke Intema ◽  
Yvonne H Sniekers ◽  
Harrie Weinans ◽  
Marieke E Vianen ◽  
Sue A Yocum ◽  
...  
Keyword(s):  
Subchondral Bone ◽  
Bone Structure ◽  
Canine Models

A tannic acid-reinforced PEEK-hydrogel composite material with good biotribological and self-healing properties for artificial joints

2021 ◽  
Author(s):  
Yuntong Liu ◽  
Dangsheng Xiong
Keyword(s):  
Composite Material ◽  
Tannic Acid ◽  
Subchondral Bone ◽  
Friction And Wear ◽  
Bone Structure ◽  
Promising Material ◽  
Self Healing ◽  
Artificial Joints ◽  
Hydrogel Composite ◽  
Joint Implants

Polyetheretherketone (PEEK) is widely considered as a promising material for joint implants but it still has limitations involving high friction and wear. Mimicking the cartilage-subchondral bone structure in natural joints,...

scholarly journals Characterization of OA development between sexes in the rat medial meniscal transection model

2019 ◽  
Author(s):  
Krishna A. Pucha ◽  
Jay M. McKinney ◽  
Julia M. Fuller ◽  
Nick J. Willett
Keyword(s):  
Articular Cartilage ◽  
Subchondral Bone ◽  
Bone Structure ◽  
Meniscal Tear ◽  
Cartilage Degradation ◽  
Mineral Density ◽  
Male And Female ◽  
Post Surgery ◽  
Medial Meniscal Tear

AbstractObjectiveOsteoarthritis (OA) is a chronic degenerative disease of the joints characterized by articular cartilage degradation. While there are clear sex differences in OA development in humans, most pre-clinical research has been conducted solely in male animals thus limiting the ability of these findings to be generalized to both sexes in the context of this disease. The objective of this study was to determine if sex impacts the progression and severity of OA in the rat medial meniscal tear (MMT) preclinical animal model used to surgically induce OA. It was hypothesized that differences would be observed between males and females following MMT surgery.DesignA MMT model was employed in male and female Lewis rats to induce OA. Animals were euthanized 3 weeks post-surgery and EPIC-μCT was used to quantitatively evaluate articular cartilage structure and composition, osteophyte volumes and subchondral bone structure.ResultsQuantitative analysis of the medial 1/3 articular cartilage via EPIC-μCT showed increased cartilage thickness and proteoglycan loss in the MMT of both sexes, when compared to sham. Additionally, both male and female animals in the MMT group had increased subchondral bone mineral density and larger total osteophyte volumes due to MMT.ConclusionThese data demonstrate that OA can be induced in both sexes using the rat MMT model. Moving forward, adding sex as a factor in preclinical OA studies should be standard practice in pre-clinical studies in order to elucidate more inclusive and translatable results into the clinic.

scholarly journals Association between radiography-based subchondral bone structure and MRI-based cartilage composition in postmenopausal women with mild osteoarthritis

2017 ◽  
Vol 25 (12) ◽  
pp. 2039-2046 ◽  
Author(s):  
J. Hirvasniemi ◽  
J. Thevenot ◽  
J. Multanen ◽  
M. Haapea ◽  
A. Heinonen ◽  
...  
Keyword(s):  
Postmenopausal Women ◽  
Subchondral Bone ◽  
Bone Structure

scholarly journals Longitudinal changes in subchondral bone structure as assessed with MRI are associated with functional outcome after high tibial osteotomy

2018 ◽  
Vol 3 (4) ◽  
pp. 205-212 ◽  
Author(s):  
Alexandra S Gersing ◽  
Pia M Jungmann ◽  
Benedikt J Schwaiger ◽  
Julia Zarnowski ◽  
Felix K Kopp ◽  
...  
Keyword(s):  
Trabecular Bone ◽  
Functional Outcome ◽  
High Tibial Osteotomy ◽  
Subchondral Bone ◽  
Bone Structure ◽  
Lysholm Score ◽  
Tibial Osteotomy ◽  
Bone Thickness ◽  
Varus Malalignment ◽  
Trabecular Number

ObjectivesThe primary objective of this study was to evaluate the effects of high tibial osteotomy (HTO) on subchondral bone structure assessed with MR-based trabecular bone imaging and the correlations of these effects with functional outcome and clinical symptoms.MethodsPatients with varus malalignment (6.2°±2.2°) and without a history of knee surgery (n=22; 3 women; 48.7±10.3 years) were included into this prospective study. 1.5T MRI was performed before and on average 1.5 years after HTO (amount of correction 4.7°±2.5°) and histomorphometric parameters of the trabecular bone were calculated for the medial/lateral tibia and femur. Functional outcome was assessed with validated scores focusing on sports activity including the Lysholm Score, Tegner Activity Scale and the adapted Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Score.ResultsApparent trabecular number significantly decreased in all compartments of the tibiofemoral joint when comparing values before and on average 1.5 years after HTO (p<0.05 for all). Decrease in apparent trabecular number was significantly higher within the medial tibia compared with the lateral compartment (mean difference −0.24 mm−1 (95% CI −0.33 to −0.14 mm−1); p<0.001). Apparent trabecular bone thickness significantly increased within 1.5 years after HTO in the lateral femur (p=0.002) and tibia (p<0.001). The Lysholm Score and Tegner Scale demonstrated an improvement of functional outcome, and the adapted WOMAC demonstrated an improvement of pain, stiffness and physical function within 1.5 years after HTO (p<0.01), with the improvement of WOMAC correlating significantly with changes in trabecular bone thickness within the medial tibia (r=−0.48; p=0.01).ConclusionThese findings indicate a reversal of the previous subchondral bone alterations in patients with varus malalignment after undergoing HTO, while pronounced subchondral changes were associated with a better functional outcome.Level of evidenceIII

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