A tannic acid-reinforced PEEK-hydrogel composite material with good biotribological and self-healing properties for artificial joints

2021 ◽  
Author(s):  
Yuntong Liu ◽  
Dangsheng Xiong
Keyword(s):  
Composite Material ◽  
Tannic Acid ◽  
Subchondral Bone ◽  
Friction And Wear ◽  
Bone Structure ◽  
Promising Material ◽  
Self Healing ◽  
Artificial Joints ◽  
Hydrogel Composite ◽  
Joint Implants

Polyetheretherketone (PEEK) is widely considered as a promising material for joint implants but it still has limitations involving high friction and wear. Mimicking the cartilage-subchondral bone structure in natural joints,...

Layered Self-Healing Composite Material with an Internal Functional Layer Based on Borosiloxane

2020 ◽  
Vol 11 (5) ◽  
pp. 1051-1059
Author(s):  
N. N. Sitnikov ◽  
I. A. Khabibullina ◽  
V. I. Mashchenko ◽  
A. V. Shelyakov ◽  
K. S. Mostovaya ◽  
...  
Keyword(s):  
Composite Material ◽  
Self Healing ◽  
Functional Layer

scholarly journals Evaluation of human subchondral bone structure using volumetric local binary patterns method

2014 ◽  
Vol 22 ◽  
pp. S349
Author(s):  
J. Thevenot ◽  
M. Finnilä ◽  
O-M. Aho ◽  
V. Tiitu ◽  
J. Rautiainen ◽  
...  
Keyword(s):  
Subchondral Bone ◽  
Bone Structure ◽  
Local Binary Patterns

Multi-responsive, injectable, and self-healing hydrogels based on benzoxaborole–tannic acid complexation

2021 ◽  
Vol 12 (39) ◽  
pp. 5623-5630
Author(s):  
Yi-Yang Peng ◽  
Qiuli Cheng ◽  
Wenda Wang ◽  
Meng Wu ◽  
Diana Diaz-Dussan ◽  
...  
Keyword(s):  
Tannic Acid ◽  
Self Healing

A bio-inspired, multi-responsive, injectable, and self-healing hydrogel was developed via the interaction of tannic acid (TA) and benzoxaborole-based linear copolymers.

scholarly journals A Robust, Tough and Multifunctional Polyurethane/Tannic Acid Hydrogel Fabricated by Physical-Chemical Dual Crosslinking

Polymers ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 239 ◽  
Author(s):  
Jie Wen ◽  
Xiaopeng Zhang ◽  
Mingwang Pan ◽  
Jinfeng Yuan ◽  
Zhanyu Jia ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Tensile Strength ◽  
Polyethylene Glycol ◽  
Hydrogen Bonds ◽  
Tannic Acid ◽  
Hydroxyl Groups ◽  
Self Healing ◽  
Physical Chemical ◽  
Biomedical Field ◽  
Physical Crosslinking

Commonly synthetic polyethylene glycol polyurethane (PEG–PU) hydrogels possess poor mechanical properties, such as robustness and toughness, which limits their load-bearing application. Hence, it remains a challenge to prepare PEG–PU hydrogels with excellent mechanical properties. Herein, a novel double-crosslinked (DC) PEG–PU hydrogel was fabricated by combining chemical with physical crosslinking, where trimethylolpropane (TMP) was used as the first chemical crosslinker and polyphenol compound tannic acid (TA) was introduced into the single crosslinked PU network by simple immersion process. The second physical crosslinking was formed by numerous hydrogen bonds between urethane groups of PU and phenol hydroxyl groups in TA, which can endow PEG–PU hydrogel with good mechanical properties, self-recovery and a self-healing capability. The research results indicated that as little as a 30 mg·mL−1 TA solution enhanced the tensile strength and fracture energy of PEG–PU hydrogel from 0.27 to 2.2 MPa, 2.0 to 9.6 KJ·m−2, respectively. Moreover, the DC PEG–PU hydrogel possessed good adhesiveness to diverse substrates because of TA abundant catechol groups. This work shows a simple and versatile method to prepare a multifunctional DC single network PEG–PU hydrogel with excellent mechanical properties, and is expected to facilitate developments in the biomedical field.

scholarly journals DEVELOPING THE COMMON MARMOSET AS A TRANSLATIONAL MODEL OF AGE-RELATED OSTEOARTHRITIS

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S104-S104
Author(s):  
Dennis M Minton ◽  
Angela J Marolf ◽  
Kelly S Santangelo ◽  
Adam B Salmon ◽  
Adam R Konopka
Keyword(s):  
Subchondral Bone ◽  
Bone Structure ◽  
Common Marmoset ◽  
Knee Joints ◽  
Micro Computed Tomography ◽  
Bone Thickness ◽  
Aging Research ◽  
Naturally Occurring ◽  
Age Related ◽  
The Common

Abstract Age is a primary risk factor for osteoarthritis (OA). The mechanisms that contribute to OA are poorly understood and disease modifying treatments have not been identified. A critical shortcoming in developing therapies is the limited number of translational models available to identify the causes of naturally occurring OA. Our goal is to use the common marmoset as a non-human primate (NHP) model of age-related OA. NHP are the closest evolutionary relative to humans and share many characteristics of human aging. The marmoset has advantages over other NHP for aging research because of their relatively short maximal lifespan and small size. Micro-computed tomography (uCT) was performed on whole-knee joints obtained from young (10 yrs, n=3) marmosets at necropsy. OA was evaluated using a clinical uCT scoring system and quantitative assessments of subchondral bone structure and ossified meniscal volume. Advancing age was positively correlated to increased uCT OA score (p<0.05, r=0.59 ), mainly through increased number and size of osteophytes and progressive subchondral bone sclerosis from the medial to both medial and lateral compartments. For marmosets displaying meniscal ossification, older marmosets had greater (p<0.05) ossified meniscal volume than middle-aged and younger marmosets, respectively. Trabecular (p=0.05) and cortical bone thickness (p<0.05) were also lower in older marmosets. These data are the first to indicate that the marmoset develops naturally occurring, age-related OA and support the pursuit of additional studies using the marmoset to identify OA mechanisms and test potential interventions.

Doxycycline effects on mechanical and morphometrical properties of early- and late-stage osteoarthritic bone following anterior cruciate ligament injury

2004 ◽  
Vol 97 (4) ◽  
pp. 1254-1260 ◽  
Author(s):  
Connor K. Pardy ◽  
John R. Matyas ◽  
Ronald F. Zernicke
Keyword(s):  
Anterior Cruciate Ligament ◽  
Bone Loss ◽  
Trabecular Bone ◽  
Subchondral Bone ◽  
Bone Structure ◽  
Femoral Condyle ◽  
Cruciate Ligament ◽  
Ligament Injury ◽  
Doxycycline Treatment ◽  
Anterior Cruciate

As posttraumatic osteoarthritis (OA) progresses, the mechanical and morphometrical properties of the subchondral bone change and may be linked to damage of the articular cartilage. Potentially to slow that progression, doxycycline was administered orally twice daily (4 mg·kg−1·day−1) in skeletally mature canines after anterior cruciate ligament transection (ACLX). To test if doxycycline significantly altered the structure and function of OA bone, we tested cancellous bone mechanical properties, measured bone mineral content, and analyzed bone structure by microcomputed tomography. Our investigation focused on subchondral trabecular bone changes in the medial femoral condyle at 36 and 72 wk after ACLX. Significant mechanical changes discovered at 36 wk post-ACLX were less obvious at 72 wk in both treated and ACLX groups. Doxycycline treatment conserved bone strain energy density at 72 wk. Doxycycline had little effect on the degradation of superficial osseous tissue at 36 wk post-ACLX; by 72 wk, doxycycline in an ACLX model limited subchondral bone loss within the first 3 mm of periarticular bone with established OA. Significant bone loss occurred in the deeper trabecular bone for all groups. Substantial architectural adaptation within deeper trabecular bone accompanied changes in mechanics in early and established OA.

Computational design and optimization of a biomimetic self-healing/cooling composite material

2007 ◽  
Author(s):  
Alejandro M. Aragón ◽  
Christopher J. Hansen ◽  
Willie Wu ◽  
Philippe H. Geubelle ◽  
Jennifer Lewis ◽  
...  
Keyword(s):  
Composite Material ◽  
Computational Design ◽  
Self Healing ◽  
Design And Optimization

scholarly journals Similarities and discrepancies in subchondral bone structure in two differently induced canine models of osteoarthritis

2010 ◽  
Vol 25 (7) ◽  
pp. 1650-1657 ◽  
Author(s):  
Femke Intema ◽  
Yvonne H Sniekers ◽  
Harrie Weinans ◽  
Marieke E Vianen ◽  
Sue A Yocum ◽  
...  
Keyword(s):  
Subchondral Bone ◽  
Bone Structure ◽  
Canine Models
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