Comparison of two models of post-traumatic osteoarthritis; temporal degradation of articular cartilage and menisci

2016 ◽  
Vol 35 (3) ◽  
pp. 486-495 ◽  
Author(s):  
Kristine M. Fischenich ◽  
Keith D. Button ◽  
Charlie DeCamp ◽  
Roger C. Haut ◽  
Tammy L. Haut Donahue
Keyword(s):  
Articular Cartilage ◽  
Post Traumatic ◽  
Temporal Degradation

scholarly journals Genetic Deletion of Interleukin-15 Is Not Associated with Major Structural Changes Following Experimental Post-Traumatic Knee Osteoarthritis in Rats

2021 ◽  
Vol 11 (15) ◽  
pp. 7118
Author(s):  
Ermina Hadzic ◽  
Garth Blackler ◽  
Holly Dupuis ◽  
Stephen James Renaud ◽  
Christopher Thomas Appleton ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Subchondral Bone ◽  
Structural Changes ◽  
Cartilage Damage ◽  
Wild Type ◽  
Significant Difference ◽  
Post Traumatic ◽  
Interleukin 15 ◽  
Joint Trauma ◽  
Surgically Induced

Post-traumatic osteoarthritis (PTOA) is a degenerative joint disease, leading to articular cartilage breakdown, osteophyte formation, and synovitis, caused by an initial joint trauma. Pro-inflammatory cytokines increase catabolic activity and may perpetuate inflammation following joint trauma. Interleukin-15 (IL-15), a pro-inflammatory cytokine, is increased in OA patients, although its roles in PTOA pathophysiology are not well characterized. Here, we utilized Il15 deficient rats to examine the role of IL-15 in PTOA pathogenesis in an injury-induced model. OA was surgically induced in Il15 deficient Holtzman Sprague-Dawley rats and control wild-type rats to compare PTOA progression. Semi-quantitative scoring of the articular cartilage, subchondral bone, osteophyte size, and synovium was performed by two blinded observers. There was no significant difference between Il15 deficient rats and wild-type rats following PTOA-induction across articular cartilage damage, subchondral bone damage, and osteophyte scoring. Similarly, synovitis scoring across six parameters found no significant difference between genetic variants. Overall, IL-15 does not appear to play a key role in the development of structural changes in this surgically-induced rat model of PTOA.

scholarly journals A mouse model of ankle-subtalar joint complex instability induced post-traumatic osteoarthritis

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Peixin Liu ◽  
Kaiwen Chen ◽  
Shuo Wang ◽  
Chunzhuo Hua ◽  
Hongtao Zhang ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Subtalar Joint ◽  
Sham Group ◽  
Step Length ◽  
Ligament Injury ◽  
Deltoid Ligament ◽  
Balance Beam ◽  
Post Traumatic ◽  
Time Required ◽  
The Right

Abstract Background Ankle-subtalar joint complex instability is not uncommonly presented in the clinic, but symptoms and signs similar to other conditions can easily lead to its misdiagnosis. Due to the lack of appropriate animal models, research on ankle-subtalar joint complex instability is limited. The aims of the present study were to establish an animal model of ankle-subtalar joint complex instability in mice and to explore its relationship with post-traumatic osteoarthritis (PTOA). Methods Twenty-one male C57BL/6J mice were randomly divided into three groups: SHAM group (sham surgery group), transected cervical ligament + anterior talofibular ligament (CL+ATFL) group, and transected cervical ligament + deltoid ligament (CL+DL) group. Two weeks after surgery, all mice underwent cage running training. Balance beam and gait tests were used to evaluate the changes in self-movement in the mice after ankle-subtalar ligament injury. Micro-CT and histological staining were used to evaluate the progress of PTOA. Results Compared with the SHAM group, balance and gait were affected in the ligament transection group. Twelve weeks after surgery, the time required to cross the balance beam in the CL+ATFL group was 35.1% longer and the mice slipped 3.6-fold more often than before surgery, and the mean step length on the right side was 7.2% smaller than that in the SHAM group. The time required to cross the balance beam in the CL+DL group was 32.1% longer and the mice slipped 3-fold more often than prior to surgery, and the average step length on the right side was 5.6% smaller than that in the SHAM group. CT images indicated that 28.6% of the mice in the CL+DL group displayed dislocation of the talus. Tissue staining suggested that articular cartilage degeneration occurred in mice with ligament transection 12 weeks after surgery. Conclusions Transected mice in the CL+ATFL and CL+DL groups displayed mechanical instability of the ankle-subtalar joint complex, and some mice in the CL+DL group also suffered from talus dislocation due to ligament injury leading to loss of stability of the bone structure. In addition, as time progressed, the articular cartilage displayed degenerative changes, which affected the ability of animals to move normally.

scholarly journals MicroRNA expression profiling of articular cartilage from a mouse model of post-traumatic OA

2016 ◽  
Vol 24 ◽  
pp. S345-S346 ◽  
Author(s):  
L.H. Kung ◽  
L. Rowley ◽  
V. Ravi ◽  
K. Bell ◽  
C.B. Little ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Mouse Model ◽  
Expression Profiling ◽  
Microrna Expression ◽  
Post Traumatic

Ameliorating Glycosaminoglycan (GAG) Loss and Cell Death in Articular Cartilage Following Single-Impact Loading

2007 ◽  
Author(s):  
Roman M. Natoli ◽  
Kyriacos A. Athanasiou
Keyword(s):  
Extracellular Matrix ◽  
Cell Death ◽  
Articular Cartilage ◽  
Impact Loading ◽  
Biomechanical Properties ◽  
Cartilage Explants ◽  
Single Impact ◽  
Igf I ◽  
Post Traumatic ◽  
Bioactive Agents

Impact loading of articular cartilage leads to post-traumatic osteoarthritis (OA) through its effects on the cells and extracellular matrix (ECM) of the tissue. Studies have shown the level of impact or injurious compression correlates with increased cell death, degradation of the ECM, and detrimental changes in biomechanical properties [1]. Recently, several bioactive agents, such as P188 and IGF-I, have shown promising results by reducing cell death following injurious compression of cartilage explants [2, 3].

MR imaging of post-traumatic articular cartilage injuries confined to the femoral trochlea

2005 ◽  
Vol 53 (1) ◽  
pp. 90-95 ◽  
Author(s):  
Rolf W. Huegli ◽  
Sonja M.C. Moelleken ◽  
Alexander Stork ◽  
Harald M. Bonel ◽  
Miriam A. Bredella ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Mr Imaging ◽  
Femoral Trochlea ◽  
Cartilage Injuries ◽  
Post Traumatic ◽  
Articular Cartilage Injuries

scholarly journals Evaluation of articular cartilage with quantitative MRI in an equine model of post‐traumatic osteoarthritis

2020 ◽  
Vol 39 (1) ◽  
pp. 63-73
Author(s):  
Abdul Wahed Kajabi ◽  
Victor Casula ◽  
Jaakko K. Sarin ◽  
Juuso H. Ketola ◽  
Olli Nykänen ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Quantitative Mri ◽  
Post Traumatic
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