scholarly journals Antioxidant impregnated ultra-high molecular weight polyethylene wear debris particles display increased bone remodeling and a superior osteogenic:osteolytic profile vs. conventional UHMWPE particles in a murine calvaria model

2015 ◽  
Vol 34 (5) ◽  
pp. 845-851 ◽  
Author(s):  
Yu Chen ◽  
Nadim J. Hallab ◽  
Yen-Shuo Liao ◽  
Venkat Narayan ◽  
Edward M. Schwarz ◽  
...  
Keyword(s):  
Molecular Weight ◽  
High Molecular Weight ◽  
Bone Remodeling ◽  
Wear Debris ◽  
Polyethylene Wear ◽  
Debris Particles ◽  
Ultra High Molecular Weight

Ultra-High Molecular Weight Polyethylene Wear Debris Generated in Vivo and in Laboratory Tests; the Influence of Counterface Roughness

1996 ◽  
Vol 210 (1) ◽  
pp. 3-10 ◽  
Author(s):  
J L Hailey ◽  
E Ingham ◽  
M Stone ◽  
B M Wroblewski ◽  
J Fisher
Keyword(s):  
Molecular Weight ◽  
High Molecular Weight ◽  
Wear Debris ◽  
Laboratory Tests ◽  
Polyethylene Wear ◽  
Uhmwpe Wear ◽  
Major Variable ◽  
Ultra High Molecular Weight ◽  
Counterface Roughness

The objective of this study was to investigate the effect of counterface roughness and lubricant on the morphology of ultra-high molecular weight polyethylene (UHMWPE) wear debris generated in laboratory wear tests, and to compare this with debris isolated from explanted tissue. Laboratory tests used UHMWPE pins sliding against stainless steel counterfaces. Both water and serum lubricants were used in conjunction with rough and smooth counterfaces. The lubricants and tissue from revision hip surgery were processed to digest the proteins and permit filtration. This involved denaturing the proteins with potassium hydroxide (KOH), sedimentation of any remaining proteins, and further digestion of these proteins with chromic acid. All fractions were then passed through a 0.2 μm membrane, and the debris examined using scanning electron microscopy. The laboratory studies showed that the major variable influencing debris morphology was counterface roughness. The rougher counter-faces produced larger numbers of smaller particles, with a size range extending below 1 μm. For smooth counterfaces there were fewer of these small particles, and evidence of larger platelets, greater than 10 μm in diameter. Analysis of the debris from explanted tissues showed a wide variation in the particle size distribution, ranging from below 1 μm up to several millimetres in size. Of major clinical significance in relation to osteolysis and loosening is roughening of the femoral components, which may lead to greater numbers of the sub-micron-sized particles.

Wear Behaviour and Wear Debris Characterization of UHMWPE on Alumina Ceramic, Stainless Steel, CoCrMo and Ti6Al4V Hip Prostheses in a Hip Joint Simulator

2010 ◽  
Vol 7 ◽  
pp. 7-25 ◽  
Author(s):  
Shi Bo Wang ◽  
Shi Rong Ge ◽  
Hong Tao Liu ◽  
Xiao Long Huang
Keyword(s):  
Molecular Weight ◽  
Stainless Steel ◽  
Size Distribution ◽  
High Molecular Weight ◽  
Hip Joint ◽  
Wear Debris ◽  
Wear Behavior ◽  
Debris Particles ◽  
Directional Motion ◽  
Ultra High Molecular Weight

Ultra-high molecular-weight polyethylene (UHMWPE) has been used in total hip replacement for the last three decades. Despite the advancements in prosthesis design, the wear of UHMWPE remains a serious clinical problem; the release of wear debris may induce osteolysis and implant loosening. Understanding of wear behavior and wear debris morphology of the polyethylene is essential to improve the reliability of hip joint implants. The investigation in this paper carried out wear simulation tests of UHMWPE on Al2O3, 316L stainless steel, CoCrMo alloy and Ti6Al4V alloy, respectively. The lubrication of plasma solution and bovine serum solution was presented in wear tests. The effect of motion and loading on the wear behavior and wear debris morphology, and the influence of femoral head material and assembly style were studied in order to obtain a better understanding of the morphology of ultra-high molecular weight polyethylene wear particles. It is shown that the wear of UHMWPE acetabular cups against metal femoral heads was significantly higher than that against ceramic heads. The presence of protein in lubricant increases the wear of UHMWPE acetabular cups on Al2O3 heads. The wear rates of UHMWPE in multi-directional motion are approximately 2.5 times of those in uni-directional motion. The size distribution range of the UHMWPE debris particles for all head materials varies from submicron particles up to several hundreds micron. The size distribution range of wear debris particles is not directly related to wear resistance of UHMWPE, but significantly influenced by wear mechanisms. The UHMWPE debris particles produced in hip wear simulation tests are classified as round debris, flake-like debris and stick debris, which are closely related to the primary mechanisms of abrasive wear, adhesive wear and fatigue wear.

Influence of gelatin and bovine serum lubricants on ultra-high molecular weight polyethylene wear debris generated in in vitro simulations

2000 ◽  
Vol 214 (5) ◽  
pp. 513-518 ◽  
Author(s):  
J Bell ◽  
A A Besong ◽  
J L Tipper ◽  
E Ingham ◽  
B M Wroblewski ◽  
...  
Keyword(s):  
Molecular Weight ◽  
High Molecular Weight ◽  
Bovine Serum ◽  
Wear Debris ◽  
Polyethylene Wear ◽  
In Vitro Tests ◽  
Suitable Alternative ◽  
Boundary Lubricant ◽  
Ultra High Molecular Weight

Ultra-high molecular weight polyethylene (UHMWPE) wear debris induced osteolysis has a major role in the late aseptic loosening and ultimate failure of total hip replacements (THR). Clinically relevant in vitro simulations of wear are essential to predict the osteolytic potential of bearing surfaces in artificial hip joints. Newborn calf or bovine serum has been accepted as a boundary lubricant for such in vitro tests, but its biological stability has been questioned. This study compared the wear factors, number of wear particles and levels of microbial contamination produced in bovine serum and a gelatin-based lubricant. The wear factors produced by the two lubricants were not significantly different, however the wear debris morphology produced was substantially different. The bovine serum became contaminated with micro-organisms within 28 h, whereas the protein-based lubricant remained uncontaminated. The results showed that bovine serum was not a stable boundary lubricant. They also showed that although the wear factors for the two solutions were not significantly different, the protein-based lubricant was not a suitable alternative to bovine serum because the wear debris produced was not clinically relevant.

Nanometer size wear debris generated from ultra high molecular weight polyethylene in vivo

Wear ◽  
2009 ◽  
Vol 266 (1-2) ◽  
pp. 349-355 ◽  
Author(s):  
Monika Lapcikova ◽  
Miroslav Slouf ◽  
Jiri Dybal ◽  
Eva Zolotarevova ◽  
Gustav Entlicher ◽  
...  
Keyword(s):  
Molecular Weight ◽  
High Molecular Weight ◽  
Wear Debris ◽  
Nanometer Size ◽  
Ultra High Molecular Weight
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