scholarly journals Change in T2* relaxation time of Hoffa fat pad correlates with histologic change in a rat anterior cruciate ligament transection model

2015 ◽  
Vol 33 (9) ◽  
pp. 1348-1355 ◽  
Author(s):  
Chao-Ying Wang ◽  
Ping-Huei Tsai ◽  
Tiing Yee Siow ◽  
Herng-Sheng Lee ◽  
Yue-Cune Chang ◽  
...  
Keyword(s):  
Anterior Cruciate Ligament ◽  
Relaxation Time ◽  
Cruciate Ligament ◽  
T2 Relaxation Time ◽  
Fat Pad ◽  
T2 Relaxation ◽  
Anterior Cruciate Ligament Transection ◽  
Histologic Change ◽  
Anterior Cruciate

scholarly journals Anterior cruciate ligament transection alters the n-3/n-6 fatty acid balance in the lapine infrapatellar fat pad

2019 ◽  
Vol 18 (1) ◽  
Author(s):  
Anne-Mari Mustonen ◽  
Reijo Käkelä ◽  
Mikko A. J. Finnilä ◽  
Andrew Sawatsky ◽  
Rami K. Korhonen ◽  
...  
Keyword(s):  
Anterior Cruciate Ligament ◽  
Fatty Acid ◽  
Cruciate Ligament ◽  
Infrapatellar Fat Pad ◽  
Fat Pad ◽  
Anterior Cruciate Ligament Transection ◽  
Anterior Cruciate

scholarly journals Relationship of Anterior Cruciate Ligament Volume and T2* Relaxation Time to Anterior Knee Laxity

2021 ◽  
Vol 9 (2) ◽  
pp. 232596712097998
Author(s):  
Hsin-Min Wang ◽  
Sandra J. Shultz ◽  
Scott E. Ross ◽  
Robert A. Henson ◽  
David H. Perrin ◽  
...  
Keyword(s):  
Relaxation Time ◽  
Cruciate Ligament ◽  
Relaxation Times ◽  
Knee Laxity ◽  
T2 Relaxation Time ◽  
T2 Relaxation ◽  
Acl Injuries ◽  
Structural Composition ◽  
Anterior Knee Laxity ◽  
Anterior Cruciate

Background: High anterior knee laxity (AKL) has been prospectively identified as a risk factor for anterior cruciate ligament (ACL) injuries. Given that ACL morphometry and structural composition have the potential to influence ligamentous strength, understanding how these factors are associated with greater AKL is warranted. Hypothesis: Smaller ACL volumes combined with longer T2* relaxation times would collectively predict greater AKL. Study Design: Cross-sectional study; Level of evidence, 3. Methods: College-aged active male (n = 20) and female (n = 30) participants underwent magnetic resonance imaging (MRI) and AKL testing. T2-weighted MRI scans were used to assess ACL volumes, and T2* relaxation times were used to assess ACL structural composition. AKL was measured via a commercial knee arthrometer. Forward stepwise linear regression with sex and weight (first step; suppressor variables) as well as ACL volume and T2* relaxation time (second step; independent variables) was used to predict AKL (dependent variable). Results: After initially adjusting for sex and weight ( R 2 = 0.19; P = .006), smaller ACL volumes combined with longer T2* relaxation times collectively predicted greater AKL ( R 2 = 0.52; P < .001; R 2 Δ = 0.32; P Δ < .001). A smaller ACL volume was the primary predictor of greater AKL ( R 2 Δ = 0.28; P < .001), with a longer T2* relaxation time trending toward a significant contribution to greater AKL ( R 2 Δ = 0.04; P = .062). After adjusting for ACL volume and T2* relaxation time, sex (partial r = 0.05; P = .735) and weight (partial r = 0.05; P = .725) were no longer significant predictors. Conclusion: AKL was largely predicted by ACL volume and to a lesser extent by T2* relaxation time (and not a person’s sex and weight). These findings enhance our understanding of how AKL may be associated with a structurally weaker ACL. The current study presents initial evidence that AKL is a cost-effective and clinically accessible measure that shows us something about the structural composition of the ACL. As AKL has been consistently shown to be a risk factor for ACL injuries, work should be done to continue to investigate what AKL may tell a clinician about the structure and composition of the ACL.

scholarly journals High-resolution MRI and micro-CT in an ex vivo rabbit anterior cruciate ligament transection model of osteoarthritis

2004 ◽  
Vol 12 (8) ◽  
pp. 614-626 ◽  
Author(s):  
Danika L. Batiste ◽  
Alexandra Kirkley ◽  
Sheila Laverty ◽  
Lisa M.F. Thain ◽  
Alison R. Spouge ◽  
...  
Keyword(s):  
Anterior Cruciate Ligament ◽  
High Resolution ◽  
Ex Vivo ◽  
Cruciate Ligament ◽  
Micro Ct ◽  
Anterior Cruciate Ligament Transection ◽  
High Resolution Mri ◽  
Anterior Cruciate

scholarly journals Effects of BIS076 in a model of osteoarthritis induced by anterior cruciate ligament transection in ovariectomised rats

2015 ◽  
Vol 16 (1) ◽  
Author(s):  
María Luisa Ferrándiz ◽  
María Carmen Terencio ◽  
María Carmen Carceller ◽  
Ramón Ruhí ◽  
Pere Dalmau ◽  
...  
Keyword(s):  
Anterior Cruciate Ligament ◽  
Cruciate Ligament ◽  
Anterior Cruciate Ligament Transection ◽  
Anterior Cruciate ◽  
Ovariectomised Rats
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